Review
Oncology
Michal Grzmil, Fabius Wiesmann, Roger Schibli, Martin Behe
Summary: Targeted radionuclide therapy (TRT) is a cancer treatment that delivers cancer-selective radiopharmaceuticals to destroy cancer cells without harming healthy tissue. This review focuses on the use of mTORC1 inhibition to improve the efficacy of TRT by delivering radiolabeled ligands. It discusses the rationale, efficacy, and safety of this combinatorial approach in cancer patients.
Review
Oncology
Alexandre el Hage, Olivier Dormond
Summary: Studies have shown that mTOR inhibitors can promote or inhibit immune responses in certain contexts, helping to enhance the anticancer effects of immunotherapy. Various resistance mechanisms to mTOR inhibitors have been identified, highlighting the potential benefits of combination therapies.
Article
Engineering, Mechanical
Zhang Tianyu, Zhang Teng, He Yuting, Du Xu, Zhang Sheng
Summary: The study showed that under UVA-acidic alternating-immersion, the residual thickness of the epoxy primer on aluminum alloys decreases linearly, and the impedance of the coated specimens changes differently in the three environments, influenced by various factors. The degradation mechanisms and electrochemical equivalent circuits were analyzed at different stages of the aging process.
ENGINEERING FAILURE ANALYSIS
(2021)
Article
Oncology
Bradley A. McGregor, Wanling Xie, Elio Adib, Walter M. Stadler, Yousef Zakharia, Aijai Alva, M. Dror Michaelson, Shilpa Gupta, Elaine T. Lam, Subrina Farah, Amin H. Nassar, Xiao X. Wei, Kerry L. Kilbridge, Lauren Harshman, Sabina Signoretti, Lynette Sholl, David J. Kwiatkowski, Rana R. McKay, Toni K. Choueiri
Summary: This study evaluated the efficacy of Sapanisertib in the treatment of refractory metastatic renal cell carcinoma (mRCC) and found that it had minimal activity independent of mTOR pathway alterations. Further therapeutic strategies are needed for patients with refractory mRCC.
JCO PRECISION ONCOLOGY
(2022)
Article
Oncology
Dafne Jacome Sanz, Juuli Raivola, Hanna Karvonen, Mariliina Arjama, Harlan Barker, Astrid Murumagi, Daniela Ungureanu
Summary: Ovarian cancer has a poor prognosis due to late diagnosis and lack of reliable biomarkers. Lipid metabolism plays a crucial role in ovarian cancer progression. Targeting enzymes involved in lipid metabolism regulation can impair cancer cell growth. Different mTOR inhibitors show varying levels of cytotoxic activity in ovarian cancer cell lines and patient-derived cancer cell cultures, suggesting the potential for targeted therapies based on subtype-specific drug vulnerabilities.
Review
Chemistry, Medicinal
Udit Chaube, Rajdeep Dey, Suman Shaw, Bhumika D. Patel, Hardik G. Bhatt
Summary: Efforts have been made to find an efficient scaffold and its substitution for mTOR inhibition in the treatment of lung cancer. A detailed literature search was conducted to find previously reported mTOR inhibitors. This review focuses on lung cancer, providing descriptions of mTOR inhibitors currently in clinical trials for lung cancer treatment. Tetrahydroquinoline (THQ) has been found to be the most efficient scaffold for exploring lung cancer treatment, and a potential substitution for the THQ scaffold may also be beneficial.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Shugeng Zhang, Shuhang Liang, Dehai Wu, Hongrui Guo, Kun Ma, Lianxin Liu
Summary: The study reveals a direct link between the Hippo and mTORC1 pathways in the control of tumour growth by regulating the activation of mTORC1 through the interaction of long noncoding RNA HPR with Raptor. Knockdown or knockout of HPR in breast cancer and cholangiocarcinoma cells led to a reduction in tumour growth, indicating the importance of this crosstalk in tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, Atsushi Hatanaka, Tsuyoshi Osawa, Tomoyoshi Soga, Akira Kobayashi
Summary: Cancer cells utilize the NRF3-mTORC1 axis, specifically in response to arginine, to promote robust growth by activating metabolic pathways and enhancing lysosome function. Inhibition of this axis impairs mitochondrial function and leads to cancer cell apoptosis, while aberrant upregulation of the axis results in tumor growth and poor prognosis. This study highlights the importance of NRF3 in arginine-dependent mTORC1 activation and provides insights into the pathophysiological role of the NRF3-mTORC1 axis in cancer development.
Article
Immunology
F. Asghari, M. H. Karimi, A. A. Pourfathollah
Summary: Due to the increase in elderly population and related social and economic problems, it is important to provide health strategies. Induction of T lymphocytes responses may be a good approach, and mTORC1 pathway inhibitors are significant in this regard. This study evaluated the effect of two mTORC1 inhibitors, Everolimus and Metformin, on age-related features of activated T cells.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Sirago, Anna Picca, Riccardo Calvani, Helio Jose Coelho-Junior, Emanuele Marzetti
Summary: This article provides an overview of mTOR signaling in skeletal muscle, with a specific focus on its role in the development of sarcopenia. Various intervention strategies targeting mTOR in sarcopenia are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Bela Vasileva, Dessislava Staneva, Natalia Krasteva, George Miloshev, Milena Georgieva
Summary: The study emphasizes the importance of interactions between DNA and nuclear proteins in maintaining genome organization and stability, particularly highlighting the role of linker histones. By knocking out the gene for linker histones in yeast cells, the researchers revealed its effects on chromatin dynamics and gene expression profiles.
Article
Food Science & Technology
Yongtao Zhang, Dongdong Wang, Hao Fu, Dan Zhao, Jiachan Zhang, Meng Li, Changtao Wang
Summary: This study analyzes the extracellular proteins of Saccharomycopsis fibuligera and explores their significance in cosmetics. The findings suggest that these proteins can enhance antioxidant enzyme activity within cells, protect skin fibroblasts from oxidative stress, and delay skin aging.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Tao Hou, Weichao Dan, Tianjie Liu, Bo Liu, Yi Wei, Chenyang Yue, Taotao Que, Yuzeshi Lei, Zixi Wang, Jin Zeng, Yizeng Fan, Lei Li
Summary: This study reveals that the deubiquitinating enzyme OTUD5 activates the mTOR signaling pathway to promote bladder cancer progression. OTUD5 stabilizes the function of RNF186, a RING-type E3 ligase, leading to the degradation of sestrin2, an inhibitor of the mTOR signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Analytical
Pablo Aguilar-Rodriguez, Adrian Mejia-Gonzalez, Sandra Zetina, Abraham Colin-Molina, Braulio Rodriguez-Molina, Nuria Esturau-Escofet
Summary: This study investigated the aging process of acrylic-based commercial paints using various analytical techniques, revealing a gradual loss of organic surfactant in all paints and unexpected behavior in two of the paints related to the properties of the acrylic binder. The results suggested that the aging of acrylic binders may vary among paints and be influenced by the interaction of different components in the formulation. Understanding these processes can provide more tools for the preservation of modern art paintings and cultural heritage.
MICROCHEMICAL JOURNAL
(2021)
Article
Cell Biology
Kerry C. Ryan, Zahra Ashkavand, Shaarika Sarasija, Jocelyn T. Laboy, Rohan Samarakoon, Kenneth R. Norman
Summary: Metabolic dysfunction and protein aggregation are common characteristics in age-related neurodegenerative diseases. Mutations in presenilin genes can lead to familial Alzheimer's disease, while loss of SEL-12/presenilin results in hyperactivation of the mTORC1 pathway. This hyperactivation exacerbates proteostasis defects and neuronal dysfunction in sel-12 mutants, highlighting the critical role of presenilin in promoting neuronal health.
