Review
Cell Biology
Dexin Shen, Lingao Ju, Fenfang Zhou, Mengxue Yu, Haoli Ma, Yi Zhang, Tongzu Liu, Yu Xiao, Xinghuan Wang, Kaiyu Qian
Summary: Melatonin, as a potential therapy for prostate cancer, has significant antioxidant and anticancer abilities. Studies have shown that melatonin can inhibit the development of prostate cancer through different pathways, and the synergistic use with other drugs may have better effects.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Ahmed S. Doghish, Ahmed Ismail, Hesham A. El-Mahdy, Mohamed A. Elkady, Mahmoud A. Elrebehy, Al-Aliaa M. Sallam
Summary: Prostate cancer is a major cause of cancer-related deaths, and miRNA plays a key role in its initiation and progression, serving as potential biomarkers for early diagnosis and personalized treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Yigeng Feng, Hongwen Cao, Zixi Song, Lei Chen, Dan Wang, Renjie Gao
Summary: Abiraterone acetate has shown impressive results in improving progression-free survival in patients with metastatic castration-resistant prostate cancer. However, some patients may develop resistance to abiraterone. This study investigates the potential of a traditional Chinese medicine called Qi Ling decoction (QLD) in attenuating abiraterone resistance in prostate cancer. The results demonstrate that QLD can promote abiraterone-induced apoptosis and cell death, and restore the sensitivity of prostate cancer cells to abiraterone. These findings suggest that QLD may serve as a potential remedy to enhance the effectiveness of abiraterone therapy for patients with castration-resistant prostate cancer.
Article
Medicine, Research & Experimental
Xia Gan, Hailing Huang, Jing Wen, Kai Liu, Yuting Yang, Xiaoning Li, Gang Fang, Yonghong Liu, Xueni Wang
Summary: The natural compound alpha-terthienyl was found to inhibit the growth of prostate cancer cells by targeting the androgen receptor and its signaling pathway. It also showed anti-prostate cancer effects in a mouse xenograft model. This study highlights the potential of alpha-terthienyl as a promising small molecule for prostate cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Kaixuan Guo, Cheng Liu, Juanyi Shi, Cong Lai, Ze Gao, Jiawen Luo, Zhuohang Li, Zhuang Tang, Kuiqing Li, Kewei Xu
Summary: Dysregulated HMMR is associated with poor prognosis in prostate cancer. HMMR promotes PCa proliferation and metastasis through interacting with AURKA and activating the mTORC2/AKT pathway. Moreover, sustained activation of mTORC2/AKT pathway upregulates E2F1, which further promotes HMMR transcription, forming a positive feedback loop that contributes to PCa progression. Administration of mTOR inhibitor partially antagonizes HMMR-mediated PCa progression.
CELL DEATH DISCOVERY
(2023)
Article
Geriatrics & Gerontology
Zhengshuai Song, Qi Cao, Bin Guo, Ye Zhao, Xuechao Li, Ning Lou, Chenxi Zhu, Gang Luo, Song Peng, Guohao Li, Ke Chen, Yong Wang, Hailong Ruan, Yonglian Guo
Summary: In this study, the researchers identified RACGAP1 as a common differentially expressed gene associated with neuroendocrine prostate cancer (NEPC). They confirmed its expression in clinical prostate cancer samples and investigated its regulatory pathways and functions. They found that RACGAP1 promoted NE transdifferentiation of prostate cancer and resistance to hormone therapy. Patients with high tumor RACGAP1 expression had shorter relapse-free survival time. This study explored the molecular mechanism of NE differentiation and may provide new insights for targeted therapy of NEPC.
Review
Oncology
Ying Dong, Xiaozeng Lin, Anil Kapoor, Yan Gu, Hui Xu, Pierre Major, Damu Tang
Summary: Prostate cancer is a leading cause of cancer death in men and treating mPC effectively remains a challenge, where RKIP may play a crucial role in suppressing its progression.
Article
Oncology
Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair, Karen E. Knudsen
Summary: This study identifies the stage-specific consequences of RB loss across cancer progression, which directly impact tumor response to clinically utilized therapeutics. It is the first to investigate the effect of RB loss on global metabolic regulation and link RB/E2F1 to redox control in multiple advanced diseases.
Article
Chemistry, Physical
Naila Zaman, Rimsha Yousaf, Zahra Akhtar, Syed Sikander Azam
Summary: In this study, nine different drug combinations targeting p27-CDK4/cyclin D1 complex were tested experimentally, and the most effective combinations were found to stabilize the active dimer. The study also highlighted the role of the p27 linker as well as environmental factors in drug efficacy.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Oncology
Dae-Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S. Rodansky, Joshua A. Urrutia, Jacob A. Schwartzman, Chao Zhang, Himisha Beltran, Mark P. Labrecque, Colm Morrissey, Jared M. Lucas, Ilsa M. Coleman, Peter S. Nelson, Eva Corey, Samuel K. Handelman, Jonathan Z. Sexton, Rahul Aggarwal, Wassim Abida, Felix Y. Feng, Eric J. Small, Daniel E. Spratt, Armand Bankhead, Arvind Rao, Emily M. Gesner, Sarah Attwell, Sanjay Lakhotia, Eric Campeau, Joel A. Yates, Zheng Xia, Joshi J. Alumkal
Summary: NEPC is the most aggressive lineage plasticity in prostate cancer, with limited treatment options. By inhibiting AR and using BET inhibitors, it is possible to block this lineage plasticity, showing promising potential for t-NEPC treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Zuolei Jing, Qianmei Liu, Wanlin Xie, Yong Wei, Jiale Liu, Yi Zhang, Wenren Zuo, Shan Lu, Qingyi Zhu, Ping Liu
Summary: The study reveals that high expression of NCAPD3 is associated with increased levels of EZH2 and MALAT1 in prostate cancer, promoting its progression. This finding highlights the significance of NCAPD3 in prostate cancer and provides a theoretical basis for further research.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Muzamil Y. Want, Takemasa Tsuji, Prashant K. Singh, James L. Thorne, Junko Matsuzaki, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Richard C. Koya, Amit Lugade, Kunle Odunsi, Sebastiano Battaglia
Summary: Elevated levels of WHSC1 are positively correlated with an immunosuppressive microenvironment in prostate cancer, according to TCGA data. In vitro studies have shown that inhibition of WHSC1 can restore antigen presentation through epigenetic regulation of gene expression. In vivo studies in immunocompetent mice also demonstrated an increase in CD8(+) T cells in tumors following treatment with a WHSC1 inhibitor, indicating the importance of a fully functional immune system in the antitumor effects of WHSC1 inhibition.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Lei Shi, Yuqian Yan, Yundong He, Binyuan Yan, Yunqian Pan, Jacob J. Orme, Jun Zhang, Wanhai Xu, Jun Pang, Haojie Huang
Summary: This study reveals that SPOP and SKP2 are two essential E3 ubiquitin ligases exerting opposite effects on 17 beta HSD4 protein degradation and intratumoral androgenesis in prostate cancer cells. Mutations in SPOP or overexpression of SKP2 contribute to prostate cancer progression by decreasing 17 beta HSD4 expression and increasing intratumoral androgen synthesis, providing potential biomarkers for effective treatment with AR-targeted therapies.
Article
Oncology
Cheemala Ashok, Neha Ahuja, Subhashis Natua, Jharna Mishra, Atul Samaiya, Sanjeev Shukla
Summary: ESRP1 plays a significant role in cancer progression, with elevated expression in carcinoma in situ and reduced expression in hypoxic cancer cells. The transcription factor E2F1 and CpG hydroxymethylation are key factors in upregulating ESRP1 expression, while hypoxia-induced TET3 downregulation leads to E2F1 repression, contributing to diminished ESRP1 expression in hypoxic conditions.
Article
Oncology
Daniela Carreno, Nestor B. Corro, Javier F. Cerda-Infante, Carolina E. Echeverria, Catalina A. Asencio-Barria, Veronica A. Torres-Estay, Gonzalo A. Mayorga-Weber, Pablo A. Rojas, Loreto P. Veliz, Pedro A. Cisternas, Viviana P. Montecinos, Ignacio F. San Francisco, Manuel A. Varas-Godoy, Paula C. Sotomayor, Maite A. Castro, Francisco J. Nualart, Nibaldo C. Inestrosa, Alejandro S. Godoy
Summary: Prostate cancer cells overexpress fructose transporters compared with benign cells, and fructose can stimulate proliferation and invasion of prostate cancer cells. This study suggests that fructose may serve as an alternative energy source for prostate cancer cells, promoting their growth and aggressiveness both in vitro and in vivo.
Article
Surgery
Agnieszka Piotrowska-Seweryn, Cezary Szymczyk, Dominik A. Walczak, Lukasz Krakowczyk, Adam Maciejewski, Grzegorz Hadasik, Janusz Wierzgon, Ryszard Szumniak, Piotr Drozdowski, Piotr Paul, Maciej Grajek
Summary: Ameloblastoma is a common locally aggressive odontogenic tumor, primarily occurring in young adults. It can be classified into four types according to the 2017 WHO classification. Radical resection with reconstruction is the preferred treatment for mandibular ameloblastomas. This study discusses the surgical treatment of mandibular ameloblastomas and explores the use of new technologies in reconstruction.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Review
Immunology
Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi
Summary: This review focuses on the role of long non-coding RNAs (lncRNAs) in thymic epithelial tumor development and discusses their potential as targets for novel therapeutic approaches. In addition, the involvement of lncRNAs in myasthenia gravis (MG)-related thymoma is also highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Stephen B. Fox, Fluer Webster, Chih-Jung Chen, Boon Chua, Laura Collins, Maaria-Pia Foschini, G. Bruce Mann, Ewan Millar, Sarah E. Pinder, Emad Rakha, Abeer Shaaban, Benjamin Y. Tan, Gary Tse, Peter Watson, Puy Hoon Tan
Summary: The ICCR has developed a new international dataset for pathology reporting of DCIS, variants of LCIS, and low-grade lesions to improve patient outcomes and promote uniform global management of breast disease. The dataset comprises core and noncore elements, taking into account current evidence and practical considerations.
Article
Oncology
Javier Octavio Mejia-Hernandez, Dinesh Raghu, Franco Caramia, Nicholas Clemons, Kenji Fujihara, Thomas Riseborough, Amina Teunisse, Aart G. Jochemsen, Lars Abrahmsen, Giovanni Blandino, Andrea Russo, Cristina Gamell, Stephen B. Fox, Catherine Mitchell, Elena A. Takano, David Byrne, Panimaya Jeffreena Miranda, Reem Saleh, Heather Thorne, Shahneen Sandhu, Scott G. Williams, Simon P. Keam, Ygal Haupt, Sue Haupt
Summary: Prostate cancer is a common male cancer, and high levels of MDM4 are associated with an increased risk of prostate cancer. Inhibiting MDM4 may serve as a novel treatment approach for prostate cancer.
Article
Pathology
Sung-liang Yu, Yi-jing Hsiao, Wendy A. Cooper, Yoon-la Choi, A. L. E. J. A. N. D. R. O. Aviles-salas, Teh-ying Chou, R. E. N. A. T. A. Coudry, Grigory A. Raskin, Stephen B. Fox, Chao-cheng Huang, Yoon Kyung Jeon, Young-hyeh Ko, Wen-hui Ku, Ghee-young Kwon, C. O. N. N. U. L. L. Leslie, Mei-chun Lin, Pei-jen Lou, C. R. I. S. T. O. V. A. M. Scapulatempo-neto, Saulo Mendoza Ramirez, N. I. K. I. T. A. Savelov, Hyo-sup Shim, Cesar Octavio Lara Torres, Isabela Werneck Cunha, L. A. R. I. S. A. Zavalishina, Yan-ming Chen
Summary: This study assessed the performance of PD-L1 diagnostic assays in NSCLC, HNSCC, and UC. The results showed that the performance of Ventana SP263 and Dako 22C3 assays was comparable in NSCLC and HNSCC. However, in UC, the performance of Ventana SP263 assay was less reliable and may impact treatment decisions.
Article
Cell Biology
Javier Octavio Mejia-Hernandez, Simon P. Keam, Reem Saleh, Fenella Muntz, Stephen B. Fox, David Byrne, Arielle Kogan, Lokman Pang, Jennifer Huynh, Cassandra Litchfield, Franco Caramia, Guillermina Lozano, Hua He, James M. You, Shahneen Sandhu, Scott G. Williams, Ygal Haupt, Sue Haupt
Summary: This study generated genetically engineered mice models that mimic human prostate cancer and provide insights into the importance of immune responses in prostate cancer. The researchers found that the type of p53 alteration affects the disruption of immune cell profiles and supports the hypothesis that individual p53 mutations confer their own oncogenic gain of function in prostate cancer.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Benjamin Yongcheng Tan, Stephen B. Fox, Sunil R. Lakhani, Puay Hoon Tan
Summary: Grading of breast phyllodes tumors (PTs) varies due to differences in weighting of grading criteria by pathologists. Key diagnostic criteria include increased stromal cellularity, stromal overgrowth, increased stromal mitoses, stromal atypia, stromal fronding, irregular tumor borders, and/or lesional heterogeneity. Clinical and radiological findings, as well as age, also play important roles in determining the diagnosis.
Review
Cell Biology
Ruwangi Udayasiri, Tongtong Luo, Kylie L. Gorringe, Stephen B. Fox
Summary: Ductal carcinoma in situ (DCIS) is a non-invasive breast tumor with the potential to progress to invasive ductal carcinoma (IDC). The current inability to accurately predict the invasive potential of DCIS leads to both over-treatment and under-treatment in patients. Better understanding of the molecular features of DCIS could improve treatment decision-making and avoid unnecessary side-effects. This review summarizes the current knowledge of DCIS and discusses future research directions.
Article
Cell Biology
Nur Diyana Md Nasir, Valerie C. Y. Koh, Ian A. Cree, Blanca I. I. Ruiz, Javier Del Aguila, Subasri Armon, Stephen B. Fox, Sunil R. Lakhani, Puay Hoon Tan
Summary: In this study, an evidence gap map (EGM) was developed based on the literature cited in the PT chapter of the breast WCT. The EGM revealed a lack of high-level evidence citations and an uneven distribution of references. Future work is needed to bridge evidence gaps and broaden citations.
Article
Oncology
Antonello Vidiri, Andrea Ascione, Francesca Piludu, Eleonora Polito, Enzo Gallo, Renato Covello, Paola Nistico, Vittoria Balzano, Barbara Pichi, Raul Pellini, Simona Marzi
Summary: In this study, the correlation between imaging parameters obtained from magnetic resonance imaging (MRI) and pathological factors in oral cavity squamous cell carcinomas (OSCCs) was investigated. The results showed that pathological factors such as inflammatory infiltrate, tumor grading, and desmoplastic reaction affected the MRI parameters. Significant relationships were found between DKI parameters and tumor-infiltrating lymphocytes (TILs). Differences in DCE-MRI parameters were also observed according to tumor grading. These findings contribute to a better understanding of OSCCs and can be used for diagnostic and prognostic purposes.
Article
Computer Science, Interdisciplinary Applications
Martina Betti, Chiara Maria Salzano, Alice Massacci, Mattia D'Antonio, Isabella Grassucci, Benedetta Marcozzi, Marco Canfora, Elisa Melucci, Simonetta Buglioni, Beatrice Casini, Enzo Gallo, Edoardo Pescarmona, Gennaro Ciliberto, Matteo Pallocca
Summary: The biomedical research field is advancing towards developing clinical trials and translational projects based on real-world evidence. To make this transition feasible, clinical centers need to work towards data accessibility and interoperability. This task is particularly challenging when applied to genomics, which has become routine through amplicon-based next-generation sequencing panels. These experiments produce numerous features per patient, and their results are often stored in static clinical reports, making critical information inaccessible to automated access and federated search consortia. This study presents a reanalysis of 4620 solid tumor sequencing samples in different histology settings and describes the bioinformatics and data engineering processes employed to create a somatic variant registry capable of dealing with the large biotechnological variability of routine genomics profiling.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Editorial Material
Oncology
Paolo Visca, Enzo Gallo, Mirella Marino
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Adi Diab, Helen Gogas, Shahneen Sandhu, Georgina V. Long, Paolo A. Ascierto, James Larkin, Mario Sznol, Fabio Franke, Tudor E. Ciuleanu, Caio Pereira, Eva Munoz Couselo, Fernanda Bronzon Damian, Michael Schenker, Aldo Perfetti, Celeste Lebbe, Gaelle Quereux, Friedegund Meier, Brendan D. Curti, Carlos Rojas, Yull Arriaga, Haisu Yang, Ming Zhou, Shruthi Ravimohan, Paul Statkevich, Mary A. Tagliaferri, Nikhil I. Khushalani
Summary: Despite the efficacy of Bempegaldesleukin (BEMPEG) in the treatment of melanoma, the PIVOT IO 001 study did not meet its primary end points, with increased toxicity observed with the combination of BEMPEG plus NIVO.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Franco Caramia, Terence P. Speed, Hui Shen, Ygal Haupt, Sue Haupt
Summary: This study found an association between dysregulation of X-chromosome inactivation and survival rate in breast cancer patients, and identified prognostic gene expression features related to chromosome abnormalities, providing new insights into female cancer risks.
Review
Cell Biology
Jia-Min B. Pang, David J. Byrne, Alice R. T. Bergin, Franco Caramia, Sherene Loi, Kylie L. Gorringe, Stephen B. Fox
Summary: In recent years, molecular findings have been incorporated into routine diagnostic practice of anatomical pathology, revolutionizing the field. Spatial transcriptomics, a group of technologies that provide transcriptome-wide expression profiling while preserving spatial origin of the data, allows analysis of highly specific areas within a tissue section and correlation of expression data with morphology, tissue type, and location relative to other structures. Some spatial transcriptomics methods are now compatible with formalin-fixed paraffin-embedded tissue (FFPE), potentially leading to their incorporation in routine anatomical pathology practice.
