期刊
ONCOTARGET
卷 8, 期 25, 页码 41113-41124出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17064
关键词
heterogeneity; cancer; drug-response
资金
- China National 973 project [2013CB911303]
- China Natural Sciences Foundation [81272456, 81470126]
- Fundamental Research Funds for the Central Universities, Ministry of Education, P.R. China
One cancer cell line is believed to be composed of numerous clones with different drug sensitivity. We sought to investigate the difference of drug-response pattern in clones from a cell line or from a single cell. We showed that 22 clones derived from 4T1 cells were drastically different from each other with respect to drug-response pattern against 11 anticancer drugs and expression profile of 19 genes associated with drug resistance or sensitivity. Similar results were obtained using daughter clones derived from a single 4T1 cell. Each daughter clone showed distinct drug-response pattern and gene expression profile. Similar results were also obtained using Bcap37 cells. We conclude that a single cancer cell can rapidly produce a population of cells with high heterogeneity of drug response and the acquisition of drug-response heterogeneity is random.
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