Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Feng Wang, Lan Zhang, Yue Xu, Yilin Xie, Shenglei Li
Summary: This study identified a series of differentially expressed genes (DEGs) between esophageal cancer (EC) and normal samples, as well as between esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC). Key genes involved in the EC process were identified, with roles in cell cycle regulation and the PI3K/Akt signaling pathway. Furthermore, the study confirmed hub genes associated with overall survival in patients with EC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Gang Yuan, Natasha M. Flores, Simone Hausmann, Shane M. Lofgren, Vladlena Kharchenko, Maria Angulo-Ibanez, Deepanwita Sengupta, Xiaoyin Lu, Iwona Czaban, Dulat Azhibek, Silvestre Vicent, Wolfgang Fischle, Mariusz Jaremko, Bingliang Fang, Ignacio I. Wistuba, Katrin F. Chua, Jack A. Roth, John D. Minna, Ning-Yi Shao, Lukasz Jaremko, Pawel K. Mazur, Or Gozani
Summary: Amplification of the chromosomal region 8p11-12 is common in lung squamous cell carcinoma (LUSC) and the NSD3 gene in this region is identified as a key regulator of LUSC tumorigenesis. NSD3 depletion attenuates tumor growth and enhances survival in LUSC, suggesting its potential as a therapeutic target. Additionally, NSD3-dependent LUSC xenografts are sensitive to bromodomain inhibition, indicating a vulnerability of LUSC to this treatment.
Article
Spectroscopy
Yafeng Qi, Lin Yang, Bangxu Liu, Li Liu, Yuhong Liu, Qingfeng Zheng, Dameng Liu, Jianbin Luo
Summary: In this study, Raman spectroscopy and deep learning were utilized for accurate and stain-free intraoperative diagnosis. By treating Raman spectral signals as sequences and converting them into two-dimensional Raman spectrograms using short-time Fourier transform as input, high performance deep learning models were achieved, surpassing traditional methods in accuracy and sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Endocrinology & Metabolism
Na Li, Yalin Li, Peixian Zheng, Xianquan Zhan
Summary: This study established immune-related gene-prognostic models in LUAD and LUSC based on mRNAsi, showing a correlation between tumor stemness index and immune cell infiltration in lung cancer tissues.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Md. Asad Ullah, Sayka Alam, Abu Tayab Moin, Tanvir Ahamed, Abdullah Mohammad Shohael
Summary: In this study, researchers investigated the molecular mechanism of the impact of COVID-19 in lung cancer patients. They identified several differentially expressed genes in common between lung cancer and COVID-19 patients, and found that COVID-19 may affect the expression of cancer-associated genes. Furthermore, the study suggests that COVID-19 may predispose lung cancer patients to other diseases and identifies potential diagnostic and molecular targets for this group of patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Medicine, General & Internal
Piaopiao Li, Hui Yuan, Xuemei Kuang, Tingting Zhang, Lei Ma
Summary: This study identified core genes and their associations with clinical characteristics and patient outcomes in LUSC and LUAD. These findings have important implications for early diagnosis and treatment of LUSC and LUAD.
Article
Oncology
Jin-Dong Li, Cheng-Yan Jin, Yan Zhang, Hang Guo, Guang-Lei Zhang, Chun-Guang Wang
Summary: This case report describes a patient with lung cancer who experienced histopathological transformation from squamous-cell carcinoma to large cell neuroendocrine carcinoma with a small fraction of small cell carcinoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Jing Ning, Shenyi Jiang, Shu Wang, Xuhong Deng, Zhiqiang Zhang, Lijie He, Daqing Wang, Youhong Jiang
Summary: GPC3 expression varies in different cancer types, and its role in lung cancer is still not well understood. However, it has been found that GPC3 is overexpressed in lung squamous cell carcinoma (LUSC), suggesting its important role in LUSC progression. Clinical trials targeting GPC3 as a therapeutic approach are currently ongoing.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Oncology
Sally C. M. Lau, Yuanwang Pan, Vamsidhar Velcheti, Kwok Kin Wong
Summary: Squamous cell lung cancers have high mortality and a lack of specific therapies. Current treatment strategies focus on epigenetic therapies and exploiting unique metabolic vulnerabilities. These novel therapies may synergize with immune checkpoint inhibitors, providing a potential treatment option.
Article
Biochemistry & Molecular Biology
Matthew Uzelac, Yuxiang Li, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Summary: The human microbiome is a collection of microbial species that exist throughout the body and regulate various bodily functions. The impact of archaea species in the microbiome has not been well explored, despite their potential metabolic interaction with host cells. This study investigates the correlation of specific archaeal species with lung adenocarcinoma and lung squamous cell carcinoma, and identifies potential molecular targets associated with the archaea microbiome. The abundance of archaeal species in lung tissue samples was assessed, revealing altered abundance in cancerous samples. Analysis of gene expression and oncogenic signaling pathways provides insights into the mechanisms of cancer development. Additionally, a machine-learning algorithm was developed to accurately distinguish lung cancer patients from healthy individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chengdi Wang, Qiuxiao Yu, Tingting Song, Zhoufeng Wang, Lujia Song, Ying Yang, Jun Shao, Jingwei Li, Yinyun Ni, Ningning Chao, Li Zhang, Weimin Li
Summary: An investigation into the immune landscape is crucial for immunotherapy strategies and predicting clinical responses in non-small-cell lung cancer patients. Using single-cell RNA sequencing, researchers have identified immune signature differences between lung adenocarcinoma and lung squamous cell carcinoma, the two major subtypes of NSCLC. They found that cytotoxic and effector T and NK cells, as well as distinct macrophage subtypes, play central roles in the immune microenvironment heterogeneity between the two subtypes. This comprehensive depiction of immune heterogeneity could aid in personalized treatment design.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Health Care Sciences & Services
Talip Zengin, Tugba Onal-Suzek
Summary: This study aimed to identify key genes and pathways for diagnostic and prognostic prediction for lung adenocarcinoma and squamous cell carcinoma through analysis of genomic and transcriptomic variations, providing potential personalized oncology biomarkers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Nozomi Kita, Natsuo Tomita, Taiki Takaoka, Shuou Sudo, Yusuke Tsuzuki, Dai Okazaki, Masanari Niwa, Akira Torii, Seiya Takano, Akio Niimi, Akio Hiwatashi
Summary: This study compared the recurrence patterns between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) after SBRT for early-stage lung cancer. It was found that SCC had a higher local recurrence rate compared to ADC, while lymph node metastasis and distant metastasis rates were not associated with histological type. Tumor diameter and histological type were correlated with local recurrence.
Article
Oncology
Oded Icht, Liran Domachevsky, David Groshar, Elizabeth Dudnik, Ofer Rotem, Aaron M. Allen, Nir Peled, Daniel Reinhorn, Oded Jacobi, Tzippy Shochat, Hanna Bernstine, Alona Zer
Summary: Patients with low tumor burden showed higher response rates, longer progression-free survival (PFS) and overall survival (OS) when treated with ICI. These results may help improve patient selection for single-agent ICI therapy and further prospective analysis is warranted.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Elizabeth Dudnik, Mor Moskovitz, Abed Agbarya, Teodor Gottfried, Tzippy Shochat, Damien Urban, Alona Zer, Ofer Rotem, Assaf Moore, Shlomit Yust, Nir Peled, Mira Wollner, Jair Bar
Summary: In patients with advanced nonsmall cell lung cancer, continuing nivolumab treatment for over 24 months can improve progression-free survival. Continuing nivolumab at a standard dose until disease progression or intolerable toxicity remains the standard treatment option.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Dermatology
Iris Amitay-Laish, Hadas Prag-Naveh, Ayelet Ollech, Batya Davidovici, Yael Anne Leshem, Igor Snast, Aron Popovtzer, Ofer Purim, Dov Flex, Michael David, Baruch Brenner, Irit Ben-Aharon, Nir Peled, Emmillia Hodak, Salomon M. Stemmer
Summary: A randomized trial showed that prophylactic topical treatment with chloramphenicol 3% + prednisolone 0.5% ointment was more effective in treating EGFRI-induced facial papulopustular rash compared to aqua cream, reducing the incidence of protocol-specified significant rash.
Article
Neurosciences
John G. Samuelsson, Noam Peled, Fahimeh Mamashli, Jyrki Ahveninen, Matti S. Hamalainen
Summary: The limitation of low spatial resolution in magneto- and electroencephalography has not been unified quantified, with previous studies focusing on linear estimation methods without noise. A new approach is presented here to quantify the spatial fidelity of source estimates, allowing for evaluation of different methods under various conditions. Results show that spatial fidelity varies significantly with signal-to-noise ratio, providing insights for interpreting M/EEG source estimates and methods development.
Article
Hematology
Oded Icht, Naama Darzi, Shai Shimony, Oded Jacobi, Daniel Reinhorn, Yosef Landman, Raz Mutai, Itamar Averbuch, Tzippy Shochat, Galia Spectre, Pia Raanani, Ofer Rotem, Elizabeth Dudnik, Nir Peled, Alona Zer, Avi Leader
Summary: VTE rates were higher among NSCLC patients treated with platinum-based chemotherapy compared to those treated with ICI. The Khorana Score did not effectively identify high-risk ICI-treated patients, suggesting the need for an ICI-specific risk model.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Oncology
Vered Fuchs, Laila Roisman, Waleed Kian, Levin Daniel, Julia Dudnik, Hovav Nechushtan, Iris Goldstein, Addie Dvir, Lior Soussan-Gutman, Roxana Grinberg, Roni Gillis, Nir Peled
Summary: The study revealed different resistance mechanisms to osimertinib in first-line therapy compared to second-line therapy, with MET amplification being a common factor. Various treatment approaches post osimertinib resistance showed acceptable overall survival, with combined therapy showing effectiveness and tolerability.
Article
Oncology
Marisa Bittoni, James Chih-Hsin Yang, Jin-Yuan Shih, Nir Peled, Egbert F. Smit, D. Ross Camidge, Rajeswara Rao Arasada, Dina Oksen, Emmanuelle Boutmy, Christopher Stroh, Andreas Johne, David P. Carbone, Paul K. Paik
Summary: This study aimed to describe characteristics, treatment, and outcomes of NSCLC patients with MET alterations in real-world clinical care. Results showed heterogeneous treatments between METamp and METex14 patients, with METamp patients more likely to have concomitant oncogenic mutations. Older age and non-smoking status were more common in METex14 patients, and MET targeted therapies could be beneficial for these rare alterations.
Article
Biotechnology & Applied Microbiology
Janan Abbas, Natan Peled, Israel Hershkovitz, Kamal Hamoud
Summary: The study found an association between vertebral morphometry and degenerative lumbar spinal stenosis (DLSS), with stenosis patients having significantly greater vertebral body length and width, but smaller bony anteriorposterior (AP) canal diameters and cross-sectional area (CSA) than the control group. Vertebral length, AP canal diameter, and laminar inclination were identified as factors significantly associated with DLSS development.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Sameh Daher, Yaacov R. Lawrence, Elizabeth Dudnik, Ekaterina Hanovich, Damien Urban, Nir Peled, Rossie Navon, Raya Leibowitz, Ariel Hammerman, Erez Battat, Teodor Gottfried, Amir Onn, Jair Bar
Summary: This study aimed to investigate clinical data and baseline blood test results as potential predictive biomarkers for the efficacy of nivolumab in advanced non-small cell lung cancer patients. The results showed a strong correlation between disease control within the first six months of treatment and prolonged overall survival. A novel score called CLAS, based on albumin and LDH levels, was proposed for predicting outcomes in nivolumab-treated NSCLC patients, although further validation is required.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vered Fuchs, Waleed Kian, Rachel Lichtenberg, Jonah M. Cooper, Areen A. Remilah, Daniel Levin, Nir Peled, Laila C. Roisman
Summary: This study describes a case series of six patients with EGFRm NSCLC who were rechallenged with osimertinib following carboplatin-based chemotherapy. The results suggest that osimertinib rechallenge may be an effective and well-tolerated treatment approach, potentially improving survival by a few months.
CLINICAL DRUG INVESTIGATION
(2022)
Review
Oncology
Waleed Kian, Melanie Zemel, Dina Levitas, Wafeek Alguayn, Areen A. Remilah, Nader Abdel Rahman, Nir Peled
Summary: The effectiveness of LDCT screening in Europe needs to be re-evaluated, and potential future approaches for LC screening guidelines should be explored.
CURRENT OPINION IN ONCOLOGY
(2022)
Review
Oncology
Christian Rolfo, Philip Mack, Giorgio Scagliotti, Charu Aggarwal, Maria E. Arcila, Fabrice Barlesi, Trever Bivona, Maximilian Diehn, Caroline Dive, Rafal Dziadziuszko, Natasha Leighl, Umberto Malapelle, Tony Mok, Nir Peled, Luis E. Raez, Lecia Sequist, Lynette Sholl, Charles Swanton, Chris Abbosh, Daniel Tan, Heather Wakelee, Ignacio Wistuba, Rebecca Bunn, Janet Freeman-Daily, Murry Wynes, Chandra Belani, Tetsuya Mitsudomi, David Gandara
Summary: Although precision medicine has had mixed impact on clinical management of patients with advanced-stage cancer overall, the advances have been dramatic for NSCLC, specifically lung adenocarcinoma, due to genomic complexity and increasing number of druggable oncogene drivers. Liquid biopsy serves as a practical alternative source for investigating tumor-derived somatic alterations, offering a minimally invasive approach for selecting targeted therapies. The most extensively studied methodology is plasma circulating tumor DNA, which has wide adoption as an alternative to tissue tumor genotyping, particularly in solid tumors like NSCLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Medicine, General & Internal
Waleed Kian, Melanie Zemel, Emily H. Kestenbaum, Keren Rouvinov, Wafeek Alguayn, Dina Levitas, Anna Ievko, Regina Michlin, Moataz A. Abod, Ismaell Massalha, Elena Chernomordikov, Adam A. Sharb, Walid Shalata, Esther Levison, Laila C. Roisman, Konstantin Lavrenkov, Nir Peled, Lior Nesher, Alexander Yakobson
Summary: This study reviewed the charts of 210 cancer patients who received the BNT162b2 mRNA COVID-19 vaccine. The results showed that 65 participants experienced mild to moderate side effects, but there was no correlation between treatment protocol type or the timing of vaccine administration and the occurrence of side effects. Six participants were hospitalized and four died. The incidence of side effects in cancer patients was similar to that in the general public.
Article
Engineering, Biomedical
Ishita Basu, Ali Yousefi, Britni Crocker, Rina Zelmann, Angelique C. Paulk, Noam Peled, Kristen K. Ellard, Daniel S. Weisholtz, G. Rees Cosgrove, Thilo Deckersbach, Uri T. Eden, Emad N. Eskandar, Darin D. Dougherty, Sydney S. Cash, Alik S. Widge
Summary: This study demonstrates that closed-loop electrical stimulation of the internal capsule can enhance cognitive control in participants with epilepsy. Decoding of task performance from electrode activity was also achieved. These findings have the potential to improve cognitive deficits in individuals with severe mental disorders.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Alexander Yakobson, Wafeek Alguayn, Walid Shalata, Daniel Levin, Tawfeek A. Kian, Amir Korngreen, Rachel Gibbs, Mahmuod A. Salah, Benzion Samueli, Konstantin Lavrenkov, Laila C. Roisman, Yulia Dudnik, Nir Peled, Yael Refaely, Waleed Kian
Summary: Epithelioid hemangioma (EH) and epithelioid hemangioendothelioma (EHE) are both rare vascular tumors, with EH usually benign and EHE having moderate malignant potential. Treatment challenges arise from their rarity and lack of guidelines, with proposed approaches including pazopanib and minimally invasive surgical resection.
CASE REPORTS IN ONCOLOGY
(2021)