期刊
NUTRIENTS
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nu9040316
关键词
angiotensin-I-converting enzyme inhibitory activity; bioactive peptides; plant proteins; enzymatic hydrolysis; bioavailability; obesity; diabetes
资金
- Center of Excellence of Natural Additives, Functional Ingredients and Health (DOKAM) [TR10/15/YNK/0146]
Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.
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