Article
Surgery
Chris Triphaus, Leonie Judd, Patricia Glaser, Marie H. Goehring, Elke Schmitt, Sabine Westphal, Christoph Fuellenbach, Simone Lindau, Kai Zacharowski, Patrick Meybohm, Suma Choorapoikayil
Summary: The study demonstrated that administering intravenous iron within 7 days before surgery effectively increased hemoglobin levels, reduced intraoperative transfusion rates, and shortened hospital stays for surgical patients with iron deficiency anemia.
Article
Surgery
Magnus Ploug, Rasmus Kroijer, Niels Qvist, Torben Knudsen
Summary: This study reports on the experience with preoperative i.v. iron treatment in surgical colorectal cancer patients in clinical practice. The results showed that preoperative i.v. iron treatment was neither associated with a rise in Hb concentrations at the time of surgery, nor with a reduction in the likelihood of receiving perioperative RBCT in colorectal cancer patients with iron deficiency anemia.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ren Zhou, Dewei Qian, Haiqing Li, Zhe Wang, Sheng Shi, Feng Shen, Lin Cheng, Dicheng Yang, Min Yu
Summary: Intraoperative red blood cell transfusion is associated with poorer clinical outcomes in non-anemic patients undergoing cardiac surgery, particularly increasing the risk of postoperative hypoxemia. Female, iron deficiency, and hemoglobin level are independent predictors of intraoperative red blood cell transfusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Letter
Medicine, General & Internal
Andrew J. Read, Akbar K. Waljee, Charity S. Chen, Robert Holleman, Kyle E. Kumbier, Sameer D. Saini
Summary: This cohort study examines the prevalence of appropriate testing for incident anemia in a large cohort from a national integrated health care system.
Article
Hematology
Harris Khan, Paige May, Elim Kuo, Preetika Pai, Katherine Boles, Ashley McGee, Tanaka Dang, Jessica Schmit
Summary: The study showed that a single 1020 mg dose of ferumoxytol administered via IV infusion is a convenient, safe, and effective treatment option for iron deficiency anemia, with decreased clinic utilization.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Oncology
Matthew T. T. McEvoy, Austin J. J. Stuckert, Maria I. I. Castellanos, Megan M. M. Gilbert, Thomas Pfeiffer, Zachary Prudowsky, Xavier Rios, Gladstone Airewele, M. Fatih Okcu, Jacquelyn M. M. Powers
Summary: This study aimed to standardize the management of young children with nutritional iron deficiency anemia (IDA) in the emergency department (ED) through the development and implementation of an evidence-based algorithm. By using quality improvement methodology, the study showed that the implementation of the algorithm significantly improved adherence to evidence-based patient care for IDA in the ED.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: This study assessed the feasibility of anemia, iron deficiency, and iron-deficiency anemia surveillance among first-trimester pregnancies using electronic health records. It found that approximately 2.7% of pregnancies had anemia, with about half of those cases having both low hemoglobin and low hematocrit. Iron deficiency was present in approximately 26.8% of pregnancies with anemia and 23.5% of pregnancies without anemia.
JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Article
Nutrition & Dietetics
Andrea J. Sharma, Nicole D. Ford, Joanna E. Bulkley, Lindsay M. Jenkins, Kimberly K. Vesco, Anne M. Williams
Summary: The feasibility of monitoring anemia, iron deficiency, and iron-deficiency anemia among pregnant women using electronic health records has been assessed. This method can be used to monitor the prevalence and trends of anemia in pregnant women, but obtaining representative estimates of iron deficiency or iron-deficiency anemia may be challenging if iron assessment is not routine.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Vito Leonardo Miniello, Maria Carmen Verga, Andrea Miniello, Cristina Di Mauro, Lucia Diaferio, Ruggiero Francavilla
Summary: The complementary feeding period between 6 and 24 months is crucial for infant nutrition and development, especially in addressing iron deficiency and anemia. Healthcare providers should follow guidelines to ensure adequate iron intake and address iron deficiency in infants during this critical period.
Article
Obstetrics & Gynecology
Michael Auerbach
Summary: Iron deficiency (ID) is a common disorder with low serum ferritin level. Transferrin saturation (TSAT) is the best indicator of iron status in early pregnancy or chronic inflammation. The guidelines do not recommend routine screening for ID, but urgent review is needed. Oral iron is associated with adverse effects, while intravenous iron is safer and more effective, especially for pregnant women with hemoglobin levels below 10.5 g/dL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Nutrition & Dietetics
Rishma Dhillon Pai, Yap Seng Chong, Lyra Ruth Clemente-Chua, Rima Irwinda, Trang Nguyen Khanh Huynh, Noroyono Wibowo, Maria Corazon Zaida Gamilla, Zaleha Abdullah Mahdy
Summary: The lack of standardized clinical practice is a global concern in the optimal management of iron deficiency and iron deficiency anemia in women, particularly in the Asia-Pacific region. This study aimed to determine best practices through a Delphi consensus process.
Article
Multidisciplinary Sciences
Filomena Gomes, Rina Agustina, Robert E. Black, Parul Christian, Kathryn G. Dewey, Klaus Kraemer, Anuraj H. Shankar, Emily R. Smith, Andrew Thorne-Lyman, Alison Tumilowicz, Megan W. Bourassa
Summary: Antenatal multiple micronutrient supplements (MMS) are more effective than iron and folic acid (IFA) supplements in reducing adverse pregnancy outcomes. MMS can also effectively prevent anemia, especially in areas with low daily iron intake and high anemia prevalence.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Multidisciplinary Sciences
Joseph Kyu-Hyung Park, Seungjun Lee, Chan Yeong Heo, Jae Hoon Jeong, Yujin Myung
Summary: Intravenous ferric carboxymaltose (IV-FCM) can effectively correct preoperative anemia in patients undergoing free flap-based breast reconstruction, with fewer side effects.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Mei-Lien Pan, Li-Ru Chen, Hsiao-Mei Tsao, Kuo-Hu Chen
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Biochemistry & Molecular Biology
Nai-Yu Ko, Li-Ru Chen, Kuo-Hu Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Environmental Sciences
Li-Hsuan Wang, Kok-Min Seow, Li-Ru Chen, Kuo-Hu Chen
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Environmental Sciences
I-Shiang Tzeng, Ming-Chang Kao, Po-Ting Pan, Chu-Ting Chen, Han-Yu Lin, Po-Chun Hsieh, Chan-Yen Kuo, Tsung-Han Hsieh, Woon-Man Kung, Chu-Hsuan Cheng, Kuo-Hu Chen
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Biochemistry & Molecular Biology
Li-Ru Chen, Kuo-Hu Chen
Summary: Soybeans and related products are nutritious and may benefit human health due to the presence of isoflavones. However, the effects of isoflavones on humans are still inconclusive. Further research is needed to explore the processing of soybeans, the types of isoflavones, and their potential health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Li-Hsuan Wang, Li-Ru Chen, Kuo-Hu Chen
Summary: Xenoestrogens (XEs) are substances that mimic endogenous estrogens to affect physiological functions, either synthetic or natural, with endocrine disrupting properties. While XEs may be associated with reproductive disorders and congenital malformations, they are more likely to exhibit tissue-specific and non-genomic actions at relatively low estrogen concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Mei-Lien Pan, Li-Ru Chen, Kuo-Hu Chen
Summary: A pre-pregnancy diagnosis of PCOS is found to be an independent and significant risk factor for subsequent miscarriage in pregnant women. The risk of subsequent miscarriage is reduced by about 1/4 for PCOS patients who undergo metformin treatment compared with those who do not.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Kok-Min Seow, Pin-Shiou Liu, Kuo-Hu Chen, Chien-Wei Chen, Luen-Kui Chen, Chi-Hong Ho, Jiann-Loung Hwang, Peng-Hui Wang, Chi-Chang Juan
Summary: This study investigated the mechanisms of polycystic ovary syndrome (PCOS) and the effects of letrozole on reproductive and metabolic disorders using a mouse model. Letrozole treatment resulted in disrupted estrous cycle, hormonal imbalances, formation of cystic follicles, glucose intolerance, and insulin resistance. Additionally, the expression of CCR5 and CCL5 in the perigonadal white adipose tissue was significantly higher in the letrozole-treated mice compared with the control group, and correlated with insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chu-Han Cheng, Li-Ru Chen, Kuo-Hu Chen
Summary: This review summarizes the molecular mechanisms, risk factors, and treatment methods for estrogen deficiency related osteoporosis (EDOP) and glucocorticoid induced osteoporosis (GIOP) in postmenopausal women. Estrogen deficiency leads to increased bone resorption and decreased bone formation, while excessive glucocorticoid usage interferes with bone remodeling and promotes bone resorption. Treatment for EDOP and GIOP includes avoiding excessive glucocorticoid use and appropriate estrogen supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
Summary: Dehydroepiandrosterone (DHEA) and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are circulating steroid hormones that play multiple roles in the human body. While DHEA supplementation may have benefits for postmenopausal women, such as alleviating vasomotor symptoms and preserving immune system integrity, its effects on cardiovascular disease and insulin sensitivity are still uncertain. Further research is needed to determine the physiological role, optimal dosage, and effects on women for DHEA.
Article
Environmental Sciences
Mei-Lien Pan, Li-Ru Chen, Kuo-Hu Chen
Summary: Prepregnancy polycystic ovary syndrome (PCOS) is an independent and significant risk factor of subsequent preterm labor. Among prepregnancy PCOS females, the risk of preterm labor is lowered by about 10% in metformin users compared with non-metformin females.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Chien-Hui Lau, Kok-Min Seow, Kuo-Hu Chen
Summary: Ovarian cancer is the deadliest gynecologic malignancy in the United States. Patients with ovarian cancer often have defects in DNA repair pathways, particularly in homologous recombination (HR), which is linked to mutations in BRCA1 or BRCA2. PARP inhibitors have emerged as a unique strategy to treat HR-deficient cancers, but further research is needed to fully understand their mechanisms and effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chih-Lin Mao, Kok-Min Seow, Kuo-Hu Chen
Summary: This article summarizes the current literature on the molecular mechanisms, safety, and effects of bevacizumab for the treatment of advanced epithelial ovarian cancer. Bevacizumab, as an inhibitor of angiogenesis, has demonstrated significant therapeutic benefits when used in combination with standard chemotherapy. However, there are still many unknown aspects of bevacizumab that require further investigation for the treatment of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pei-Qi Lim, I-Hung Han, Kok-Min Seow, Kuo-Hu Chen
Summary: Most patients with advanced epithelial ovarian cancers (EOCs) have a high recurrence rate and low 5-year survival rate. Hyperthermic intraperitoneal chemotherapy (HIPEC) emerges as a new therapeutic alternative that directly contacts tumors and produces cytotoxicity. Studies have shown better survival outcomes for patients undergoing HIPEC, both for primary advanced and recurrent ovarian cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Li-Ting Wang, Li-Ru Chen, Kuo-Hu Chen
Summary: Osteoporosis, caused by an imbalance of bone turnover, is a significant global health issue. Estrogen deficiency is the main cause of hormone-related osteoporosis in postmenopausal women, while glucocorticoid-induced osteoporosis is the most common drug-induced type. This review discusses the mechanisms of bone turnover, the pathophysiology of osteoporosis, and its treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)