Article
Agronomy
Cornelia Purcarea, Vasile Laslo, Adriana Ramona Memete, Eliza Agud, Florina Miere (Groza), Simona Ioana Vicas
Summary: This study demonstrates the potential of proline as an osmoprotectant to alleviate the genotoxic effects caused by cadmium exposure in plants. The results show that the application of proline before or after cadmium treatment reduces DNA damage and chromosomal aberrations.
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Article
Environmental Sciences
Iasmini Nicoli Galter, Ian Drumond Duarte, Maressa Malini, Francielen Barroso Aragao, Ian de Oliveira Martins, Livia Dorch Rocha, Maria Tereza Weitzel Dias Carneiro, Kamila Soares do Espirito Santo, Jose Augusto de Oliveira David, E. Silvia Tamie Matsumoto
Summary: The Itapemirim River in Brazil's state of Espirito Santo is considered a vital water resource, but continuous anthropogenic contamination is posing environmental threats. The study found that the water quality of the river is compromised, with genotoxic and mutagenic effects observed in various cells, indicating the need for action plans to restore its quality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
M. Alaguprathana, M. Poonkothai, Mysoon M. Al-Ansari, Latifah Al-Humaid, Woong Kim
Summary: This study assessed the cytogenotoxic effect of untreated and methyl orange treated on Allium cepa roots. It was found that roots exposed to treated dye solution had higher root growth, root length, and mitotic index, while roots exposed to untreated dye solution showed higher mitotic inhibition and chromosomal abnormalities. The research can be used as a biomarker to detect the genotoxic effects of textile dyes on biota.
ENVIRONMENTAL RESEARCH
(2022)
Article
Toxicology
Beyza Merve Yildiz, Deniz Yuzbasioglu, Zehranur Yuksekdag, Demet Cetin, Fatma Unal, Zekiye Suludere
Summary: Exopolysaccharide EPSKC27L isolated from Lactobacillus salivarius (new genus name Ligilactobacillus) KC27L strain exhibits antioxidant properties and does not pose genotoxic risk at appropriate concentrations. EPSKC27L also reduces DNA damage induced by mitomycin-C, methyl methanesulfonate, and hydrogen peroxide.
TOXICOLOGY IN VITRO
(2023)
Article
Environmental Sciences
Duygu Aydin, Burcu Yuksel
Summary: This study demonstrates that the use of vermicompost tea can alleviate the damage caused by methylisothiazolinone to plants, promoting plant growth and development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ali Acar
Summary: Diquat dibromide, a commonly used herbicide in agriculture, was found to have dose-dependent toxic effects on plants, affecting physiological, genetic, and biochemical parameters. Increasing doses of diquat dibromide resulted in oxidative stress, decreased chlorophyll pigment levels, and various adverse effects on plant health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Medicine, Legal
Niels Hadrup, Marie Frederiksen, Anoop K. Sharma
Summary: Boron is widely used as a flame retardant in insulation products, and high exposure may lead to unwanted health effects. It is mainly absorbed through the gastrointestinal tract after oral exposure, with intact skin serving as a barrier. Boron is primarily excreted via urine, and skin exposure can be fatal. Data on inhalation toxicity is limited, but skin exposure to boric acid has proven fatal in some cases.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Ali Acar
Summary: This study demonstrated that royal jelly exhibited therapeutic effects in reducing the toxic impact of sodium benzoate on physiological, genetic, and biochemical parameters. Additionally, royal jelly showed a positive interaction with antioxidant enzyme residues, highlighting its potential benefits for human health and the environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andreja Juric, Irena Brcic Karaconji, Nevenka Kopjar
Summary: The study found that HGA in strawberry tree honey posed no significant cytotoxic threat to human peripheral blood lymphocytes in vitro, had a negligible potential for causing cytogenetic damage in treated cells, and efficiently counteracted the detrimental cytogenetic effects of the antineoplastic drug irinotecan. Further research is needed to explore the safety profile of HGA and its potential for developing new nutraceutical products.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Akemi Vieira Hosokawa, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Thays Millena Alves Pedroso, Rinneu Elias Borges, Susi Missel Pacheco, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Habitat loss and fragmentation pose significant threats to biodiversity. The use of bioindicators can provide insight into the health of the environment. A study conducted in agricultural areas found higher genotoxic damage in bats compared to a control area.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Alice Lopes, Marcelino Benvindo-Souza, Wanessa Fernandes Carvalho, Hugo Freire Nunes, Phamella Neres de Lima, Matheus Santos Costa, Edson Jose Benetti, Vinicius Guerra, Simone Maria Teixeira Saboia-Morais, Carolina Emilia Santos, Karina Simoes, Rogerio Pereira Bastos, Daniela de Melo e Silva
Summary: The study evaluated the genotoxic, mutagenic, and histopathological hepatic responses of Dendropsophus minutus tadpoles to acute exposure to the herbicide glyphosate and the surfactant polyoxyethylene amine. Results showed that both glyphosate and polyoxyethylene amine have potential genotoxic, mutagenic, and hepatotoxic effects in the tadpoles, with polyoxyethylene amine showing a higher impact. Findings emphasize the need for continued monitoring of amphibian populations in agricultural areas to mitigate the long-term impacts of pollutants on anuran tadpoles.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
Raphael B. de Souza, Cleiton Pereira de Souza, Jose Roberto Guimaraes
Summary: This study evaluated the phytotoxicity and genotoxicity of Eprinomectin, a veterinary drug widely used in the agricultural sector. The results showed that Eprinomectin affected root development and germination speed, as well as induced chromosomal aberrations and micronuclei. Therefore, the release of Eprinomectin into the environment should be minimized.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Toxicology
Mariel Valdes-Arellanes, Gerardo Ortega-Hernandez, Dorali M. Cervantes-Santos, Michael Joshue Rendon-Barron, Eduardo Osiris Madrigal-Santillan, Jose Antonio Morales-Gonzalez, Rogelio Paniagua-Perez, Eduardo Madrigal-Bujaidar, Isela Alvarez-Gonzalez
Summary: The study demonstrated that the venom of Ophryacus undulatus and Ophryacus smaragdinus had the capacity to induce micronuclei and cytotoxic damage in mice, while the venom of Ophryacus sphenophrys showed no genotoxic or cytotoxic effects.
Review
Plant Sciences
Eduardo Madrigal-Santillan, Jacqueline Portillo-Reyes, Eduardo Madrigal-Bujaidar, Manuel Sanchez-Gutierrez, Jeannett A. Izquierdo-Vega, Julieta Izquierdo-Vega, Luis Delgado-Olivares, Nancy Vargas-Mendoza, Isela Alvarez-Gonzalez, Angel Morales-Gonzalez, Jose A. Morales-Gonzalez
Summary: This article explores the bioactive compounds of Opuntia spp and their potential in preventing diseases. Part 1 focuses on its effects on cardiovascular diseases, diabetes, obesity, hepatoprotection, infertility, and chemoprevention. Part 2 summarizes the data from published research on its neuroprotective, anti-inflammatory, antiulcerative, antimicrobial, antiviral potential, and its role in treating skin wounds. By providing scientific evidence, it aims to encourage further studies on the pharmacological and therapeutic effects of Opuntia spp.
Review
Plant Sciences
Nancy Vargas-Mendoza, Eduardo Madrigal-Santillan, Isela Alvarez-Gonzalez, Eduardo Madrigal-Bujaidar, Liliana Anguiano-Robledo, Jose Leopoldo Aguilar-Faisal, Mauricio Morales-Martinez, Luis Delgado-Olivares, Elda Victoria Rodriguez-Negrete, Angel Morales-Gonzalez, Jose A. Morales-Gonzalez
Summary: Muscle health is crucial for human mobility and can be affected by various factors such as aging, oxidative stress, malnutrition, and lack of exercise. Nutritional factors play a vital role in maintaining the balance necessary for muscle function and recovery. Phytochemicals, particularly curcumin and sulforaphane, have shown positive effects on muscle function, recovery, and prevention of muscle atrophy. Future research may explore novel compounds as potential treatments for muscle-related medical conditions.
Article
Plant Sciences
Erika Anayetzi Chavez-Bustos, Angel Morales-Gonzalez, Liliana Anguiano-Robledo, Eduardo Osiris Madrigal-Santillan, Carmen Valadez-Vega, Olivia Lugo-Magana, Jorge Alberto Mendoza-Perez, Tomas Alejandro Fregoso-Aguilar
Summary: Bauhinia forficata is a tree used in alternative medicine as an anti-diabetic agent. This study investigated its hypoglycemic, antioxidant, and genoprotective activities, and found that it has the potential to be used as an adjuvant therapy for diabetes.
Article
Plant Sciences
Jose Antonio Guerrero-Solano, Mirandeli Bautista, Josue Vidal Espinosa-Juarez, Luis Alfonso Moreno-Rocha, Gabriel Betanzos-Cabrera, Liana Claudia Salanta, Minarda De la O. Arciniega, Elena G. Olvera-Hernandez, Osmar Antonio Jaramillo-Morales
Summary: Pharmacological treatment of pain often leads to undesirable effects, so it is important to explore natural, safe, and effective alternatives. Pomegranate has been used as a preventive and therapeutic agent for its antinociceptive effect, and different parts of the fruit display unique pharmacological activities. This study evaluated the antinociceptive effect of pomegranate extracts and juices from three varieties, and found that they had promising pharmacodynamic properties for the treatment of pain.
Article
Environmental Sciences
Eduardo Madrigal-Bujaidar, Rogelio Paniagua-Perez, Michael Joshue Rendon-Barron, Jose Antonio Morales-Gonzalez, Eduardo O. Madrigal-Santillan, Isela Alvarez-Gonzalez
Summary: The study evaluated the DNA damaging capacity and oxidative effects of venlafaxine on the brain and liver of ICR mice. The results showed significant impact on both tissues, with more pronounced effects observed in the liver. Further investigation is needed to determine the clinical relevance of these findings.
Article
Plant Sciences
Eduardo Osel Olvera-Roldan, Jose Melesio Cristobal-Luna, Yuliana Garcia-Martinez, Maria Angelica Mojica-Villegas, Ricardo Perez-Pasten-Borja, Gabriela Gutierrez-Salmean, Salud Perez-Gutierrez, Rosa Virginia Garcia-Rodriguez, Eduardo Madrigal-Santillan, Jose A. Morales-Gonzalez, German Chamorro-Cevallos
Summary: The study aimed to evaluate the effects of Spirulina maxima on diabetic male rats in terms of body weight, glycemia, sexual behavior, sperm quality, testosterone levels, sex organ weights, and the activity of antioxidant enzymes. The results showed that Spirulina maxima significantly improved sexual behavior and sperm quality in diabetic animals.
Article
Chemistry, Inorganic & Nuclear
Melvin Nadir Rosalez, Eunice D. Farfan-Garcia, Jesus Badillo-Romero, Ricardo Ivan Cordova-Chavez, Jose G. Trujillo-Ferrara, Jose A. Morales-Gonzalez, Marvin A. Soriano-Ursua, Marlet Martinez-Archundia
Summary: A study examined a boron-containing compound with a similar chemical structure to acetaminophen and found it to have higher analgesic effect and lower hepatotoxicity. In the mouse experiment, the compound showed a longer latency time and less liver damage compared to acetaminophen. Therefore, it is a better option for analgesic medication.
Review
Microbiology
Jeannett Alejandra Izquierdo-Vega, Rubi Joseline Castillo-Juarez, Manuel Sanchez-Gutierrez, Miguel A. Ares, Miguel A. de la Cruz
Summary: Enteroaggregative Escherichia coli (EAEC) strains cause severe diarrhea outbreaks globally and are commonly resistant to antibiotics. The characteristic adherence pattern of stacked bricks on the intestinal epithelium depends on a plasmid called aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. AggR acts as a master regulator, transcribing and activating the main virulence genes in EAEC.
POLISH JOURNAL OF MICROBIOLOGY
(2023)
Article
Oncology
Ignacio Escobar-Munguia, Ricardo Berea-Baltierra, Angel Morales-Gonzalez, Eduardo Madrigal-Santillan, Liliana Anguiano-Robledo, Jose A. Morales-Gonzalez
Summary: An NLI of >= 2.6 is found to have a low prognostic impact on early postsurgical complications in patients with colorectal cancer, with low predictive accuracy. Preoperative chemotherapy is also identified as a risk factor for post-surgical complications.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Nancy Vargas-Mendoza, Angel Morales-Gonzalez, Eduardo Osiris Madrigal-Santillan, Marcelo Angeles-Valencia, Liliana Anguiano-Robledo, Laura Ligia Gonzalez-Lopez, Alejandra Sosa-Gomez, Tomas Fregoso-Aguilar, Cesar Esquivel-Chirino, Yahel Anahi Ruiz-Velazco-Benitez, Jose A. Morales-Gonzalez
Summary: Physical exercise induces physiological changes, including oxidative stress and cellular signaling. Antioxidants from plant extracts can activate cellular protective systems and impact athletic performance.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Review
Cell Biology
Diana Rodriguez-Vera, Antonio Abad-Garcia, Nancy Vargas-Mendoza, Rodolfo Pinto-Almazan, Eunice Farfan-Garcia, Jose Morales-Gonzalez, Marvin Soriano-Ursua
Summary: The potential of polyphenols for treating chronic-degenerative diseases, especially neurodegenerative diseases, is attractive but still subject to debate regarding the optimal polyphenol selection, mechanisms of action, and efficacy. This review compiles and discusses the basics and advances in the field, as well as provides suggestions for using natural and synthetic polyphenols alone or in combination with stem cell assays. Polyphenols can induce various responses in stem cells, offering insights into neurodegeneration. Additionally, polyphenols are being explored as innovative therapies for neurodegenerative diseases and related metabolic disorders. Flavonoids are suggested as the best natural polyphenols due to their ameliorative effects, but other polyphenols are also being investigated. While limitations in bioactivity hinder their conventional use, some natural polyphenols and derivatives show promise for improvement based on their induced effects. Current findings suggest that polyphenols can enhance stem cell therapy against targeted diseases.
NEURAL REGENERATION RESEARCH
(2022)
Article
Horticulture
Eduardo Madrigal-Santillan, Jacqueline Portillo-Reyes, Eduardo Madrigal-Bujaidar, Manuel Sanchez-Gutierrez, Paola E. Mercado-Gonzalez, Jeannett A. Izquierdo-Vega, Nancy Vargas-Mendoza, Isela Alvarez-Gonzalez, Tomas Fregoso-Aguilar, Luis Delgado-Olivares, Angel Morales-Gonzalez, Liliana Anguiano-Robledo, Jose A. Morales-Gonzalez
Summary: Opuntia spp. is a widely distributed genus with diverse species in Africa, Asia, Australia, and America, with Mexico having the largest number of wild species. Its bioactive compounds, including pigments, vitamins, flavonoids, and phenolic compounds, have been found to have preventive effects against cardiovascular diseases, diabetes, obesity, hepatoprotective effects, effects on human infertility, and chemopreventive and/or antigenotoxic capacities. This review aims to provide scientific evidence of the beneficial properties of Opuntia spp. and to encourage further research on its pharmacological and therapeutic effects.
