Article
Gastroenterology & Hepatology
Ruixue Ren, Yong He, Dong Ding, Aoyuan Cui, Huarui Bao, Jing Ma, Xin Hou, Yu Li, Dechun Feng, Xiaoling Li, Suthat Liangpunsakul, Bin Gao, Hua Wang
Summary: Aging exacerbates alcohol-induced liver injury through down-regulation of the neutrophilic SIRT1-C/EBP alpha-miR-223 axis, which is also observed in chronic alcohol users with acute intoxication. This axis could be a therapeutic target for the prevention and treatment of ALD.
Article
Nutrition & Dietetics
Tohfa Kabir, Haruki Yoshiba, Afifah Zahra Agista, Halima Sultana, Yusuke Ohsaki, Chiu-Li Yeh, Ryota Hirakawa, Hiroko Tani, Tomoki Ikuta, Tomonori Nochi, Suh-Ching Yang, Hitoshi Shirakawa
Summary: The study found that Gnetin C, a derivative with health-promoting properties, can prevent nonalcoholic fatty liver disease (NAFLD), reduce weight gain and liver damage, and improve blood sugar and insulin sensitivity.
Article
Food Science & Technology
Leticia Lacalle-Bergeron, David Izquierdo-Sandoval, Alfredo Fernandez-Quintela, Maria P. Portillo, Juan Vicente Sancho, Felix Hernandez, Tania Portoles
Summary: Untargeted metabolomics with IMS-HRMS was used to study the effects of resveratrol and pterostilbene supplementation on the metabolic fingerprint of the liver in rats with induced liver steatosis. Different alterations in liver metabolism were observed with the two supplements. Resveratrol affected lysophospholipid metabolism, while pterostilbene affected vitamins and derivatives. The use of IMS provided additional structural information for confident identification.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Camilla Dalby Hansen, Eva-Marie Gram-Kampmann, Johanne Kragh Hansen, Mie Balle Hugger, Bjorn Staehr Madsen, Jane Moller Jensen, Sara Olesen, Nikolaj Torp, Ditlev Nytoft Rasmussen, Maria Kjaergaard, Stine Johansen, Katrine Prier Lindvig, Peter Andersen, Katrine Holtz Thorhauge, Jan Christian Brond, Pernille Hermann, Henning Beck-Nielsen, Sonke Detlefsen, Torben Hansen, Kurt Hojlund, Maja Sofie Thiele, Mads Israelsen, Aleksander Krag
Summary: This 6-month randomized controlled trial examined the effects of a low-carbohydrate, high fat (LCHF) diet on type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). The results showed that compared to a high-carbohydrate, low-fat (HCLF) diet, the LCHF diet resulted in greater improvements in glycemic control and weight loss, but these improvements were not sustained at the 3-month follow-up.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Siyu Li, Xiaoyan Zheng, Xiaoya Zhang, Hongxiang Yu, Bing Han, Yueying Lv, Yan Liu, Xiaoqiao Wang, Zhigang Zhang
Summary: Exposure to Deltamethrin induces hepatic steatosis, oxidative stress, inflammation, and apoptosis in quails. The Nrf2/TGF-beta 1/Smad3 signaling pathway plays a crucial role in DLM-induced liver fibrosis, and the addition of resveratrol can alleviate this fibrosis by activating Nrf2 expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Nobuharu Tamaki, Noora Ahlholm, Panu K. Luukkonen, Kimmo Porthan, Suzanne R. Sharpton, Veeral Ajmera, Yuko Kono, Shravan Dave, Aijaz Ahmed, Vinay Sundaram, Michael J. Wilkinson, Heather Patton, Hersh Gupta, Vanessa Cervantes, Christie Hernandez, Scarlett J. Lopez, Ria Loomba, Amanda Baumgartner, Lisa Richards, Perttu E. T. Arkkila, Katriina Nemes, Helena Isoniemi, Hannele Yki-Jaervinen, Rohit Loomba
Summary: First-degree relatives of patients with NAFLD with advanced fibrosis have a significantly increased risk of advanced fibrosis, indicating the need for routine screening.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Lin Fan, Zhen Fu, Yan Xiong, Shaojun Ye, Yanfeng Wang, Guizhu Peng, Qifa Ye
Summary: Establishing a novel rat model of stable steatotic liver transplantation can reduce the number of animals used for experiments. The study found significant increases in plasma triglyceride, glucose, portal insulin levels, and liver lipid content in the high-fat diet group compared to the standard chow diet group. After 6 weeks, stable liver steatosis was successfully formed, demonstrating the potential for using this model in future research on steatotic liver transplantation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tongwang Luo, Sheng Jiang, Bin Zhou, Quanjiang Song, Jing Du, Ping Liu, Xiaodu Wang, Houhui Song, Chunyan Shao
Summary: The harm of nonalcoholic fatty liver disease is increasing, and urgent prevention and treatment measures are needed. Isoorientin, an effective ingredient in Chinese herbal medicine, has been found to reduce oxidative damage and lipid accumulation in nonalcoholic fatty liver disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Article
Multidisciplinary Sciences
Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen
Summary: The flavonoid corylin, isolated from Psoralea corylifolia, has been found to exhibit longevity properties in yeast, human cells, and mice. Traditional Chinese medicine has long been believed to increase lifespan, but identifying the specific molecules responsible for this effect has been challenging. Through screening traditional Chinese medicines and isolating compounds, researchers identified corylin as a key molecule in Psoralea corylifolia that extends lifespan in various organisms.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Estelle Guillot, Anna Lemay, Manon Allouche, Sara Vitorino Silva, Hanna Coppola, Florence Sabatier, Francoise Dignat-George, Alexandre Sarre, Anne-Christine Peyter, Stephanie Simoncini, Catherine Yzydorczyk
Summary: Individuals born with intrauterine growth restriction (IUGR) have an increased risk of cardiovascular diseases (CVDs). This study found that endothelial colony-forming cells (ECFCs) in male rats with IUGR exhibited dysfunction, related to oxidative stress and stress-induced premature senescence (SIPS). Treatment with resveratrol (R), a polyphenol compound, improved the functionality of ECFCs in the IUGR group by increasing proliferation, capillary-like sprout formation, nitric oxide production, and endothelial nitric oxide synthase expression, while reducing oxidative stress and reversing SIPS. However, no effects of R were observed in the control group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Namkyun Kim, Jae-Hyung Roh, Hanbyul Lee, Doyeon Kim, Sung Jae Heo
Summary: This study aimed to investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and sleep apnea (SA).
Article
Multidisciplinary Sciences
Diego Saenz de Urturi, Xabier Buque, Begona Porteiro, Cintia Folgueira, Alfonso Mora, Teresa C. Delgado, Endika Prieto-Fernandez, Paula Olaizola, Beatriz Gomez-Santos, Maider Apodaka-Biguri, Francisco Gonzalez-Romero, Ane Nieva-Zuluaga, Mikel Ruiz de Gauna, Naroa Goikoetxea-Usandizaga, Juan Luis Garcia-Rodriguez, Virginia Gutierrez de Juan, Igor Aurrekoetxea, Valle Montalvo-Romeral, Eva M. Novoa, Idoia Martin-Guerrero, Marta Varela-Rey, Sanjay Bhanot, Richard Lee, Jesus M. Banales, Wing-Kin Syn, Guadalupe Sabio, Maria L. Martinez-Chantar, Ruben Nogueiras, Patricia Aspichueta
Summary: Altered methionine metabolism is associated with weight gain in obesity. In this study, the authors demonstrate that inhibiting methionine adenosyltransferase has beneficial effects in preventing and reversing obesity, insulin resistance, and fatty liver. This is achieved by increasing energy expenditure and FGF21 secretion.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yuhui He, Huan Wang, Shiling Lin, Tao Chen, Dennis Chang, Yibin Sun, Chenxiang Wang, Yang Liu, Yusheng Lu, Jianyuan Song, Shaohua Li, Wen Xu, Yanxiang Lin, Yanfang Zheng, Xian Zhou, Qiumei Huang, Mingqing Huang
Summary: This study investigated the effect of curcumin and resveratrol as a potential combination therapy for metabolic associated fatty liver disease (MAFLD). The combination of curcumin and resveratrol exhibited synergistic effects in reducing lipid accumulation and hepatic steatosis. Network pharmacology analysis revealed the involvement of the PI3K/AKT/mTOR and HIF-1 signaling pathways in the synergistic action of curcumin and resveratrol.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Kalliopi Pafili, Sabine Kahl, Lucia Mastrototaro, Klaus Strassburger, Dominik Pesta, Christian Herder, Jennifer Putzer, Bedair Dewidar, Mona Hendlinger, Cesare Granata, Nina Saatmann, Aslihan Yavas, Sofiya Gancheva, Geronimo Heilmann, Irene Esposito, Matthias Schlensak, Michael Roden
Summary: Impaired mitochondrial function is a common feature of subcutaneous and visceral adipose tissue in obesity, non-alcoholic fatty liver, and steatohepatitis. Dysfunction specifically in visceral adipose tissue is associated with fatty liver disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hyun Yang, Motoshi Hayano, Patrick T. Griffin, Joao A. Amorim, Michael S. Bonkowski, John K. Apostolides, Elias L. Salfati, Marco Blanchette, Elizabeth M. Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M. Ross, Giuseppe Coppotelli, Margarita V. Meer, Ryan Rogers-Hammond, Daniel L. Vera, Yuancheng Ryan Lu, Jeffrey W. Pippin, Michael L. Creswell, Zhixun Dou, Caiyue Xu, Sarah J. Mitchell, Abhirup Das, Brendan L. O'Connell, Sachin Thakur, Alice E. Kane, Qiao Su, Yasuaki Mohri, Emi K. Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A. Rego, Meredith Gregory-Ksander, Tatjana C. Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J. Wagers, Kazuo Tsubota, Stephen J. Bonasera, Carlos M. Palmeira, Jonathan G. Seidman, Christine E. Seidman, Norman S. Wolf, Jill A. Kreiling, John M. Sedivy, George F. Murphy, Richard E. Green, Benjamin A. Garcia, Shelley L. Berger, Philipp Oberdoerffer, Stuart J. Shankland, Vadim N. Gladyshev, Bruce R. Ksander, Andreas R. Pfenning, Luis A. Rajman, David A. Sinclair
Summary: All living things experience increased entropy, resulting in the loss of genetic and epigenetic information. In yeast, this loss occurs due to the relocation of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity and age. Through the ICE system, it is found that faithful DNA repair accelerates aging at multiple levels, including the erosion of the epigenetic landscape and DNA methylation. However, this aging process can be reversed by OSK-mediated rejuvenation, supporting the information theory of aging.
Review
Biochemistry & Molecular Biology
Inaki Milton-Laskibar, Jenifer Trepiana, Maria Teresa Macarulla, Saioa Gomez-Zorita, Laura Arellano-Garcia, Alfredo Fernandez-Quintela, Maria P. Portillo
Summary: The Mediterranean diet may have beneficial effects in the prevention and treatment of COVID-19, due to its antioxidant and anti-inflammatory properties.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Marco Sancen, Asier Leniz, Maria Teresa Macarulla, Marcela Gonzalez, Inaki Milton-Laskibar, Maria P. Portillo
Summary: Studies have shown that moderate beer consumption can have beneficial effects on cardiovascular diseases. However, the presence of alcohol in beer is a concern, especially for individuals at risk. Non-alcoholic beer has been found to be more effective than conventional beer in preventing oxidative stress, preserving endothelial function, and inhibiting thrombogenic activity. However, conventional beer has shown to increase HDL-cholesterol levels more than non-alcoholic beer, which may be attributed to its higher polyphenol content.
Article
Biochemistry & Molecular Biology
Catia R. Lopes, Joana S. Silva, Joana Santos, Matilde S. Rodrigues, Daniela Madeira, Andreia Oliveira, Ana Moreira-de-Sa, Vanessa S. Lourenco, Francisco Q. Goncalves, Henrique B. Silva, Ana Patricia Simoes, Anabela P. Rolo, Paula M. Canas, Angelo R. Tome, Carlos M. Palmeira, Joao Pedro Lopes, Rodrigo A. Cunha, Paula Agostinho, Samira G. Ferreira
Summary: Alzheimer's disease predominantly affects women and is characterized by metabolic deregulation and synaptic failure. In a study on female APPswe/PS1dE9 mice, a model for early AD, it was found that these mice exhibited learning and memory deficits, increased anxiety-like behavior, and signs of fear generalization. The prefrontal cortex showed decreased long-term potentiation and reduced levels of sirtuin-1 and sestrin-2, while synaptic markers remained unchanged. However, activation of sirtuin-1 did not restore abnormal cortical plasticity in APP/PS1 female mice; instead, its inhibition increased plasticity. These findings suggest that mood and memory dysfunction in early AD may be associated with a decrease in synaptic plasticity and sirtuin-1 levels in the prefrontal cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Maitane Gonzalez-Arceo, Jenifer Trepiana, Leixuri Aguirre, Jone Ibarruri, Marta Martinez-Sanz, Marta Cebrian, Isidra Recio, Maria P. Portillo, Saioa Gomez-Zorita
Summary: Extracts rich in proteins from microalgae Chlorella vulgaris and Nannochloropsis gaditana, as well as macroalga Gracilaria vermiculophylla, show potential in preventing lipid accumulation in liver cells. The three algae extracts are effective in increasing different catabolic pathways involved in triglyceride metabolism, but with different underlying mechanisms.
Review
Biochemistry & Molecular Biology
Ivo F. Machado, Raul G. Miranda, Daniel J. Dorta, Anabela P. Rolo, Carlos M. Palmeira
Summary: Reactive oxygen species (ROS) are important second messengers in metabolic processes and signaling pathways. Imbalance between ROS generation and antioxidant defenses leads to overproduction of ROS and subsequent oxidative damage, which disrupt cellular function. Oxidative stress plays a role in liver pathologies such as ischemia-reperfusion injury (LIRI), non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC). Polyphenols like quercetin, resveratrol, and curcumin have shown therapeutic effects by regulating ROS levels in liver injury conditions. This review summarizes the effects of polyphenols on oxidative damage in LIRI, NAFLD, and HCC.
Article
Biochemistry & Molecular Biology
Laura Arellano-Garcia, Jenifer Trepiana, J. Alfredo Martinez, Maria P. Portillo, Inaki Milton-Laskibar
Summary: This study compared the potential benefits of a viable probiotic (Lactobacillus rhamnosus GG) and its parabiotic on oxidative stress, inflammation, DNA damage, and cell death in the liver of rats with diet-induced NAFLD. Both the viable and heat-inactivated forms of Lactobacillus rhamnosus GG partially prevented the body weight increase induced by the fatty liver diet, with the viable form being more effective at decreasing hepatic triglyceride content. Both treatments also showed reductions in serum transaminase levels and restored antioxidant enzyme activities, nonenzymatic antioxidant protection, and total antioxidant capacity in the rats. These results demonstrate that both forms of Lactobacillus rhamnosus GG can partially prevent liver oxidative stress and inflammation in rats with diet-induced NAFLD.
Review
Biochemistry & Molecular Biology
Ivo F. Machado, Carlos M. Palmeira, Anabela P. Rolo
Summary: Liver ischemia-reperfusion injury (LIRI) is a major cause of complications in liver resection and transplantation. Mitochondrial dysfunction is recognized as a hallmark of LIRI and exacerbates cellular injury. Protecting mitochondria through regulation of mitochondrial biogenesis, fission/fusion, and mitophagy can ameliorate LIRI and improve patient outcomes.
Review
Biochemistry & Molecular Biology
Maitane Gonzalez-Arceo, Ivan Gomez-Lopez, Helen Carr-Ugarte, Itziar Eseberri, Marcela Gonzalez, M. Pilar Cano, Maria P. Portillo, Saioa Gomez-Zorita
Summary: This review summarizes the effects of isorhamnetin on obesity, showing that it can reduce adipogenesis and improve glycemic control. Further research, including animal studies and clinical trials, is needed to confirm its efficacy in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
L. Arellano-Garcia, M. T. Macarulla, A. Cuevas-Sierra, J. A. Martinez, M. P. Portillo, I. Milton-Laskibar
Summary: Insulin resistance and type 2 diabetes are obesity-related health conditions with increasing prevalence. This study found that administering a probiotic or heat-inactivated Lactobacillus rhamnosus GG effectively prevented diet-induced insulin resistance in rats, with the heat-inactivated form showing better efficacy.