期刊
NUTRIENTS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu9070677
关键词
chlorogenic acid; colitis; inflammation; gut microbiota; Akkermansia
资金
- National Natural Science Foundations of China [81473020, 81502801]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Collegiate Natural Science Foundation of Jiangsu Province [16KJB330005]
Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage. Moreover, ChA could significantly suppress the secretion of IFN gamma, TNF alpha, and IL-6 and the colonic infiltration of F4/80(+) macrophages, CD3(+) T cells, and CD177(+) neutrophils via inhibition of the active NF-kappa B signaling pathway. In addition, ChA decreased the proportion of Firmicutes and Bacteroidetes. ChA also enhanced a reduction in fecal microbiota diversity in DSS treatedmice. Interestingly, ChA treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in colitis mice. ChA acted as the intestine-modifying gut microbial community structure, resulting in a lower intestinal and systemic inflammation and also improving the course of the DSS-induced colitis, which is associated with a proportional increase in Akkermansia.
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