期刊
NUTRIENTS
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/nu9050432
关键词
vitamin D supplementation; bone turnover markers; osteocalcin; procollagen type 1 N-terminal propeptide; crosslaps; bone-specific alkaline phosphatase
资金
- Laboratory of the Division of Endocrinology and Metabolism
- Austrian National Bank [13878, 13905, 14621]
- project FP7-HEALTH [HEALTH. 2011.2.4.2-2, 278249]
- project EU-HOMAGE [HEALTH.2012.2.1.1-2, 305507]
Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment. Vitamin D supplementation is widely used to prevent and treat musculoskeletal diseases but existing data on vitamin D effects on markers of bone resorption and formation are inconsistent. We therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial, a single-center, double-blind, randomized, placebo-controlled trial (RCT) performed at the Medical University of Graz, Austria (2011-2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D (25[ OH] D) levels <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for eight weeks. One hundred ninety-seven participants (60.2 +/- 11.1 years; 47% women) were included in this analysis. Vitamin D had no significant effect on bALP (mean treatment effect (MTE) 0.013, 95% CI -0.029 to 0.056 mu g/L; p = 0.533), CTX (MTE 0.024, 95% CI -0.163 to 0.210 ng/ mL, p = 0.802), OC (MTE 0.020, 95% CI -0.062 to 0.103 ng/mL, p = 0.626), or P1NP (MTE -0.021, 95% CI -0.099 to 0.057 ng/ mL, p = 0.597). Analyzing patients with 25(OH) D levels <50 nmol/L separately (n = 74) left results largely unchanged. In hypertensive patients with low 25(OH) D levels, we observed no significant effect of vitamin D supplementation for eight weeks on BTMs.
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