期刊
NEUROSCIENCE BULLETIN
卷 33, 期 6, 页码 737-746出版社
SPRINGER
DOI: 10.1007/s12264-017-0166-6
关键词
Autism spectrum disorders; Drosophila; Chromatin remodeling; Synaptic scaffolding; Synaptic transmission
资金
- National Natural Science Foundation of China [31471031, 31400927, 31671045]
- Natural Science Foundation of Jiangsu Province, China [BK20140623]
In the past decade, numerous genes associated with autism spectrum disorders (ASDs) have been identified. These genes encode key regulators of synaptogenesis, synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.
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