Familial Parkinson’s Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2

Epidemiology, environmental risk factors and genetics of Parkinson's disease

(2017) Anna Delamarre et al.   PRESSE MEDICALE

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress

(2016) Kai Tao et al.   Neuroscience Bulletin

Echinacoside Protects Against MPP+-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation

(2016) Qing Zhao et al.   Neuroscience Bulletin

Regulation of autophagic flux by CHIP

(2015) Dongkai Guo et al.   Neuroscience Bulletin

Autophagic activity in neuronal cell death

(2015) Robert W. Button et al.   Neuroscience Bulletin

Regulation of mitophagy in ischemic brain injury

(2015) Yang Yuan et al.   Neuroscience Bulletin

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease

(2014) Hilal Unal Gulsuner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway

(2014) R Xu et al.   Cell Death & Disease

HtrA Protease Family as Therapeutic Targets

(2013) Joanna Skorko-Glonek et al.   CURRENT PHARMACEUTICAL DESIGN

Adiponectin offers protection against L166P mutant DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation

(2013) Xuemei Li et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Monomer DJ-1 and Its N-Terminal Sequence Are Necessary for Mitochondrial Localization of DJ-1 Mutants

(2013) Chinatsu Maita et al.   PLoS One

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

(2012) Haigang Ren et al.   Molecular Neurodegeneration

Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease

(2012) Jin-yong Tian et al.   NEUROSCIENCE LETTERS

Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome

(2011) Beatriz Alvarez-Castelao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidized DJ-1 Interacts with the Mitochondrial Protein BCL-XL

(2011) Haigang Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

(2011) K Fu et al.   ONCOGENE

DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells

(2010) Haigang Ren et al.   CANCER LETTERS

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

(2010) B Li et al.   CELL DEATH AND DIFFERENTIATION

BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity

(2010) Sebastian Deeg et al.   JOURNAL OF CELL BIOLOGY

The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

(2010) Jörg Hartkamp et al.   MOLECULAR CELL

Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6

(2009) E Giaime et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Molecular Basis for the Structural Instability of Human DJ-1 Induced by the L166P Mutation Associated with Parkinson’s Disease†

(2008) Peter C. Anderson et al.   BIOCHEMISTRY

DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death

(2008) J-S Mo et al.   CELL DEATH AND DIFFERENTIATION

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

(2008) M. P. van der Brug et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA