Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain

Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons

(2016) Amy E. Clipperton-Allen et al.   Autism Research

Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus

(2016) Ying Zhang et al.   CELL RESEARCH

Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits

(2016) Adam W. Oaks et al.   CEREBRAL CORTEX

Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors

(2016) S. Ha et al.   JOURNAL OF NEUROSCIENCE

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Lessons learned from studying syndromic autism spectrum disorders

(2016) Yehezkel Sztainberg et al.   NATURE NEUROSCIENCE

SHANK3 controls maturation of social reward circuits in the VTA

(2016) Sebastiano Bariselli et al.   NATURE NEUROSCIENCE

Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links

(2016) S.W. Hulbert et al.   NEUROSCIENCE

Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

(2016) Saša Peter et al.   Nature Communications

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

(2016) Xiaoming Wang et al.   Nature Communications

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

(2016) Adam J Harrington et al.   eLife

Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders

(2016) Xiangling Meng et al.   eLife

Striatal Circuits as a Common Node for Autism Pathophysiology

(2016) Marc V. Fuccillo   Frontiers in Neuroscience

Dissecting the phenotypes of Dravet syndrome by gene deletion

(2015) Moran Rubinstein et al.   BRAIN

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice

(2015) John J. McMahon et al.   NEUROBIOLOGY OF DISEASE

Loss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like Phenotypes

(2015) Aya Ito-Ishida et al.   NEURON

Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice

(2015) Dario Cupolillo et al.   NEUROPSYCHOPHARMACOLOGY

Generation of cell-type-specific gene mutations by expressing the sgRNA of the CRISPR system from the RNA polymerase II promoters

(2015) Jiaqiang Wang et al.   Protein & Cell

Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

(2014) Patrick E. Rothwell et al.   CELL

Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

(2014) Amy E. Clipperton-Allen et al.   HUMAN MOLECULAR GENETICS

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

(2014) Hao Yin et al.   NATURE BIOTECHNOLOGY

Cellular origins of auditory event-related potential deficits in Rett syndrome

(2014) Darren Goffin et al.   NATURE NEUROSCIENCE

Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

(2014) Ling-jie He et al.   Nature Communications

Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice

(2014) Luis G. Rabaneda et al.   Cell Reports

Oxytocin modulates social interaction but is not essential for sexual behavior in male mice

(2013) Virgínia Meneghini Lazzari et al.   BEHAVIOURAL BRAIN RESEARCH

Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation

(2013) M. Lang et al.   HUMAN MOLECULAR GENETICS

The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism

(2013) A Di Martino et al.   MOLECULAR PSYCHIATRY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

(2012) Lianne Robinson et al.   BRAIN

Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome

(2012) Thorfinn T. Riday et al.   JOURNAL OF CLINICAL INVESTIGATION

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

(2012) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure

(2012) Zhaofei Wu et al.   PLoS One

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors

(2011) Roger L.H. Pobbe et al.   HORMONES AND BEHAVIOR

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Adult Neural Function Requires MeCP2

(2011) C. M. McGraw et al.   SCIENCE

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome

(2010) Shalaka A. Mulherkar et al.   NEUROBIOLOGY OF DISEASE

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

(2009) R. C. Samaco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

(2009) Alexia Thomas et al.   PSYCHOPHARMACOLOGY

The use of lentiviral vectors combined with Cre/loxP to investigate the function of genes in complex behaviors

(2009) Scott Heldt   Frontiers in Molecular Neuroscience

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

(2008) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders

(2008) Maria Luisa Scattoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cerebellar modulation of frontal cortex dopamine efflux in mice: Relevance to autism and schizophrenia

(2008) Guy Mittleman et al.   SYNAPSE