Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

Succinate Accumulation and Ischemia-Reperfusion Injury: Of Mice but Not Men, a Study in Renal Ischemia-Reperfusion

(2016) L. G. M. Wijermars et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ischemic A/D transition of mitochondrial complex I and its role in ROS generation

(2016) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial complex I

(2016) Christophe Wirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Toxicity of a novel therapeutic agent targeting mitochondrial complex I

(2015) CC Low Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

(2015) Liang Zhang et al.   EBioMedicine

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Characterisation of the active/de-active transition of mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation

(2014) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Respiratory Substrates Regulate S-Nitrosylation of Mitochondrial Proteins through a Thiol-Dependent Pathway

(2014) Allen H. K. Chang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mitochondria selectiveS-nitrosation by mitochondria-targetedS-nitrosothiol protects against post-infarct heart failure in mouse hearts

(2014) Carmen Methner et al.   EUROPEAN JOURNAL OF HEART FAILURE

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity

(2014) H. Angerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Change of Mitochondrial Complex I Increases ROS Sensitivity During Ischemia

(2013) Natalia Gorenkova et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I

(2013) Marion Babot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I

(2013) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mammalian Complex I Pumps 4 Protons per 2 Electrons at High and Physiological Proton Motive Force in Living Cells

(2013) Maureen O. Ripple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling

(2012) Brian C Smith et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The clinical spectrum of the m.10191T>C mutation in complex I-deficient Leigh syndrome

(2012) VICTORIA NESBITT et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide production during ischemia–reperfusion in the perfused rat heart: A comparison of two methods of measurement

(2012) Juha P. Näpänkangas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease

(2012) Puneet Anand et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Oxygen Free Radicals Originating from Mitochondrial Complex I Contribute to Oxidative Brain Injury Following Hypoxia-Ischemia in Neonatal Mice

(2012) Z. V. Niatsetskaya et al.   JOURNAL OF NEUROSCIENCE

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the membrane domain of respiratory complex I

(2011) Rouslan G. Efremov et al.   NATURE

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): The significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals

(2010) S. Tsuyoshi Ohnishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production

(2010) Alexandra V. Kareyeva et al.   FEBS LETTERS

Ischemia-Induced Changes in Cerebral Mitochondrial Free Fatty Acids, Phospholipids, and Respiration in the Rat

(2010) Dandan Sun et al.   JOURNAL OF NEUROCHEMISTRY

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Characterization of two different acyl carrier proteins in complex I from Yarrowia lipolytica

(2009) Krzysztof Dobrynin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein denitrosylation: enzymatic mechanisms and cellular functions

(2009) Moran Benhar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rolandic Mitochondrial Encephalomyelopathy and MT-ND3 Mutations

(2009) Klaus G.E. Werner et al.   PEDIATRIC NEUROLOGY

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

(2008) Florian L. Muller et al.   BIOCHEMICAL JOURNAL

Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment

(2008) Werner J.H. Koopman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance

(2008) Chris E. Cooper et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

ΔΨm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

(2003) Tatyana V. Votyakova et al.   JOURNAL OF NEUROCHEMISTRY