Article
Food Science & Technology
Esin Yalcinkaya, Mustafa Mert Basaran, Mehmet Emin Tunckasik, Gulce Naz Yazici, Cigdem Elmas, Sinan Kocaturk
Summary: This study compared the safety and efficacy of different topical agents for surgical wound healing. The results showed that HPE had the most advanced healing stage with higher re-epithelialization and collagen accumulation values, as well as lower inflammatory cell count and granulation tissue. TB and PI also demonstrated good healing effects. HPE can be a safe, effective, and cheap agent for surgical wounds.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Celine Abueva, Hyun Seok Ryu, Jun Won Min, Phil Sang Chung, Hyeon Sook You, Myung Suk Yang, Seung Hoon Woo
Summary: The study synthesized a quaternary ammonium chitosan derivative, which when complexed with povidone-iodine showed increased effectiveness against multidrug-resistant bacteria and fungi, with no cytotoxic effects and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Dermatology
JiHui Chen, Qin Zou, Michael R. Hamblin, Xiang Wen
Summary: The clinical trial involving 58 PV patients showed that wet silver-containing dressings were significantly more effective than wet to dry povidone-iodine dressings in wound healing, with fewer dressing changes, faster healing time, shorter hospital stay, lower pain scores, and higher patient satisfaction. No significant adverse reactions were observed between the two groups.
DERMATOLOGIC THERAPY
(2021)
Review
Pharmacology & Pharmacy
Chi Yuan, Jian Liao, Liying Zheng, Lingzhi Ding, Xiao Teng, Xuesong Lin, Le Wang
Summary: This review examines the association between leptin and wound healing, speculating on the molecular mechanisms and the need for further research to understand its specific role in different phases of wound repair.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Paulo J. Alves, Ruben T. Barreto, Brigitte M. Barrois, Luc G. Gryson, Sylvie Meaume, Stan J. Monstrey
Summary: Biofilms play a major role in delaying chronic wounds from healing and pose a significant treatment challenge due to their resistance towards antimicrobial agents. However, there is a window of opportunity post-debridement when biofilms are more susceptible to topical antiseptics. Among commonly used antiseptics, PVP-I stands out for its broad spectrum of antimicrobial activity, potent antibiofilm efficacy, lack of acquired resistance, low cytotoxicity, good tolerability, and wound healing promotion.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Shaydier Argel, Melissa Castano, Daiver Estiven Jimenez, Sebastian Rodriguez, Maria Jose Vallejo, Cristina Isabel Castro, Marlon Andres Osorio
Summary: In this study, bioactive wound dressings were successfully developed by loading the antibacterial povidone-iodine and anti-inflammatory acetylsalicylic acid into bacterial nanocellulose (BNC). The structure and mechanical properties of the dressings were characterized by scanning electron microscopy and mechanical tests. The release assays and histology confirmed the diffusion of the bioactive compounds in porcine skin. Antimicrobial experiments and protein denaturation tests further confirmed the antibacterial and anti-inflammatory properties of the dressings.
Article
Surgery
Ryo Maemoto, Hiroshi Noda, Kosuke Ichida, Yasuyuki Miyakura, Nao Kakizawa, Erika Machida, Hidetoshi Aizawa, Takaharu Kato, Masahiro Iseki, Taro Fukui, Yuta Muto, Shota Fukai, Shingo Tsujinaka, Yuuri Hatsuzawa, Fumiaki Watanabe, Masakazu Nagamori, Jun Takahashi, Yasuaki Kimura, Shimpei Maeda, Noriya Takayama, Ryotaro Sakio, Rei Takahashi, Tsutomu Takenami, Natsumi Matsuzawa, Makiko Mieno, Toshiki Rikiyama
Summary: This trial evaluated the superiority of intraoperative wound irrigation with povidone-iodine compared with saline for reducing surgical site infection. The results showed that the irrigation with povidone-iodine did not significantly reduce the incidence of incisional SSI, suggesting a need for reconsideration of the current recommendation.
Review
Dermatology
Christopher Girgis, Mehmet A. Suludere, Andrew Crisologo, Lawrence A. Lavery
Summary: This article reviews laboratory studies, animal wound studies, and clinical studies on the efficacy and safety of iodine-based wound products in wound healing. It concludes that both iodine-based wound products are safe and do not impede wound healing, have no higher infection risks, and do not require more amputations compared to other modalities.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2023)
Review
Pharmacology & Pharmacy
Alina Chelmus-Burlacu, Lenuta Profire, Dragos Pieptu
Summary: This paper evaluates recent published data on the effectiveness of povidone-iodine as a wound care option and its impact on wound healing. The results show that povidone-iodine has similar antimicrobial efficacy but controversial effects on wound healing. Recent data focuses on comparing different antiseptics and proposing algorithms for wound management. However, the heterogeneity in experimental designs emphasizes the importance of standardized antimicrobial tests and clinical guidelines.
Review
Orthopedics
Mohammad-H Ebrahimzadeh, Mohammad-R Safdari, Ali Moradi, Sedighe Rastaghi, Mahla Daliri
Summary: This systematic review and meta-analysis focused on the effectiveness of dilute povidone-iodine (PI) wound irrigation in preventing post-operative periprosthetic joint infection (PJI) following total joint arthroplasty (TJA). The results showed that PI irrigation can reduce the risk of post-operative infection compared to normal saline, but there was no significant difference compared to chlorhexidine or undetermined comparators. Therefore, PI irrigation seems to be an efficient preventive measure for PJI in TJA.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Article
Nutrition & Dietetics
Camille Togo, Ana Paula Zidorio, Vivian Goncalves, Patricia Botelho, Kenia de Carvalho, Eliane Dutra
Summary: This systematic review summarizes the current evidence on the effect of oral or enteral probiotic therapy on wound healing in humans. The results indicate that probiotic therapy may have a positive impact on wound improvement, but strong evidence is still lacking. Further controlled clinical research is needed to explore the effects of specific probiotic strains, wound types, and target populations.
Review
Medicine, General & Internal
Shubham Gupta, Sangita Shinde, Raju K. Shinde
Summary: This study compares the application of povidone iodine and cadexomer iodine in wound management, evaluating their effectiveness in reducing biofilms, decreasing wound size, and promoting wound healing.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Surgery
Rod J. Rohrich, Jasson T. Abraham, Brendan Alleyne, Justin Bellamy
Summary: This article describes simple preventative strategies during rhinoplasty procedures to minimize the risk of disease transmission, particularly discussing the use of povidone-iodine in prophylaxis during the perioperative period.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Nursing
Li Li, Yu Wang, Shouyan Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy of chlorhexidine and povidone-iodine in preventing postoperative surgical site infections (SSI) and relevant bacterial data. The results indicated that chlorhexidine was more effective than povidone-iodine in preventing SSI, and the two disinfectants had different effects on bacterial colonization depending on the type of incision.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Biochemistry & Molecular Biology
Cheryl Leong, Paul L. Bigliardi, Gopu Sriram, Veonice B. Au, John Connolly, Mei Bigliardi-Qi
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2018)
Article
Chemistry, Analytical
Y. Dancik, G. Sriram, B. Rout, Y. Zou, M. Bigliardi-Qi, P. L. Bigliardi
Article
Allergy
Elizabeth J. Phillips, Paul Bigliardi, Andreas J. Bircher, Ana Broyles, Yoon-Seok Chang, Wen-Hung Chung, Rannakoe Lehloenya, Maja Mockenhaupt, Jonny Peter, Munir Pirmohamed, Jean-Claude Roujeau, Neil H. Shear, Luciana Kase Tanno, Jason Trubiano, Rocco Valluzzi, Annick Barbaud
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Bryan Siu-Yin Ho, Eliza Xin Pei Ho, Collins Wenhan Chu, Srinivas Ramasamy, Mei Bigliardi-Qi, Paola Florez de Sessions, Paul Lorenz Bigliardi
Article
Multidisciplinary Sciences
Bryan Siu-Yin Ho, Candida Vaz, Srinivas Ramasamy, Elaine Guo Yan Chew, Jameelah Sheik Mohamed, Huma Jaffar, Axel Hillmer, Vivek Tanavde, Mei Bigliardi-Qi, Paul Lorenz Bigliardi
SCIENTIFIC REPORTS
(2019)
Article
Gastroenterology & Hepatology
Kewin T. H. Siah, Amelia Santosa, Cynthia K. Y. Cheung, Alex Y. S. Soh, Paul L. Bigliardi
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Dermatology
Hilary Kung-Yu Ho, Paul Lorenz Bigliardi, Olga Stelmashenko, Srinivas Ramasamy, Michael Postlethwaite, Mei Bigliardi-Qi
Summary: Traditionally, skin sensation was thought to be initiated by cutaneous sensory afferents and Merkel cells, with keratinocytes playing no role. However, recent evidence suggests that keratinocytes can also initiate skin sensation by receiving and transmitting sensory stimuli. TAS2R14, a chemosensory receptor, has been found to be functionally expressed in epidermal keratinocytes, potentially enabling the cells to recognize harmful chemical substances.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Engineering, Environmental
Gopalakrishnan Venkatesan, Yuri Dancik, Arup Sinha, Hpone Myint Kyaw, Ramasamy Srinivas, Thomas L. Dawson, Mei Bigliardi, Paul Bigliardi, Giorgia Pastorin
Summary: This study aimed to reduce the skin sensitization potential of p-phenylenediamine (PPD) in permanent hair dye products. By introducing novel side chains and synthesizing derivatives with lower cytotoxicity and sensitization potential, the penetration of PPD into the skin and likelihood of causing allergic reactions were minimized.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Primary Health Care
Arthur S. Nguyen, Brian Thielen, Paul L. Bigliardi, Ronda S. Farah
Summary: The increased focus on infection control measures during the COVID-19 pandemic has highlighted the dermatological consequences of intensified hand hygiene, particularly for healthcare workers at risk of developing contact dermatitis. Individuals with a history of atopy are especially vulnerable. Gloves and frequent handwashing undermine the skin barriers, leading to dermatitis.
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2021)
Article
Toxicology
Gopalakrishnan Venkatesan, Zhi Chiaw Lim, Aneesh Karkhanis, Yub Raj Neupane, Yuri Dancik, Chenyuan Huang, Paul Bigliardi, Giorgia Pastorin
Summary: PPD is commonly used in oxidative hair dyes but has adverse health effects. New PPD derivatives were proposed as safer alternatives. This study investigated the detoxification pathways of 6 synthesized PPD analogues in HaCaT skin cells, finding that compounds with nucleophile groups detoxify faster than PPD.
ARCHIVES OF TOXICOLOGY
(2022)
Letter
Dermatology
Puneet Arora, Kevin J. Gaddis, Paul L. Bigliardi
Article
Chemistry, Multidisciplinary
Gopalakrishnan Venkatesan, Yuri Dancik, Yub Raj Neupane, Aneesh Karkhanis, Paul Bigliardi, Giorgia Pastorin
Summary: This study examines the safety and efficacy of novel aromatic amines as potential substitutes for Paraphenylenediamine (PPD) in hair dyes. The compounds were designed to have lower binding affinity to skin proteins, higher water solubility, and natural black color. The results show that these derivatives are safe, effective, and permanent alternatives to PPD.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Food Science & Technology
Puneet Arora, Evin T. Magner, Paul L. Bigliardi
Summary: A case study is reported where a patient without prior allergies developed a strong and spreading delayed-type hypersensitivity reaction to Melianthus plants, nectar, and synthetic pigment derived from it. The first proven case of allergic contact dermatitis to ellagic acid (EA) was identified, which is present in various plants, fruits, and nuts regularly consumed by humans. It is important to be cautious about the potential dangers of specific allergic reactions to these additives used in natural medicines, as they are increasingly being used worldwide.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gopalakrishnan Venkatesan, Yuri Dancik, Arup Sinha, Mei Bigliardi, Ramasamy Srinivas, Thomas Dawson, Suresh Valivaveettil, Paul Lorenz Bigliardi, Giorgia Pastorin
NEW JOURNAL OF CHEMISTRY
(2019)