Article
Food Science & Technology
Chao Tang, Weiwei Zhou, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu
Summary: This study found that the probiotic Lactobacillus plantarum Q16 modulates lipid and energy metabolism, improves lipid profile, and regulates colonic microbiota composition to protect against high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Nutrition & Dietetics
Narongsuk Munkong, Surasawadee Somnuk, Nattanida Jantarach, Kingkarnonk Ruxsanawet, Piyawan Nuntaboon, Vaiphot Kanjoo, Bhornprom Yoysungnoen
Summary: Red rice bran extract (RRBE) has been shown to have anti-diabetic, anti-inflammatory, and antioxidant properties. This study investigated the anti-hepatic steatosis and anti-dyslipidemic properties of RRBE in high-fat diet-fed mice and found that RRBE alleviated hepatosteatosis, dyslipidemia, liver injury, inflammation, and oxidative stress by regulating key genes involved in lipid metabolism, inflammation, oxidative stress, and apoptosis.
Article
Biochemistry & Molecular Biology
Fahimeh Zamani-Garmsiri, Seyyed Mohammad Reza Hashemnia, Maryam Shabani, Molood Bagherieh, Solaleh Emamgholipour, Reza Meshkani
Summary: The combination therapy of MET and GEN showed significant benefits against NAFLD in HFD-fed mice, reducing body weight, liver weight, fasting blood glucose levels, liver triglyceride levels, and inflammation while regulating key genes and pathways related to lipid metabolism, glucose production, and inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Cell Biology
Jing-Hua Wang, Seung-Ju Hwang, Dong-Woo Lim, Chang-Gue Son
Summary: The ethanol extract of Cynanchum atratum (CAE) was found to have anti-fatty liver effects. A six-week treatment of CAE in mice on a high-fat, high-fructose diet significantly reduced body weight, liver weight, and mesenteric fat. CAE also improved blood parameters and liver damage, and normalized gene and protein expression related to liver lipid metabolism. Additionally, CAE decreased hepatic inflammation and fecal endotoxin levels, suggesting its potential for treating chronic metabolic diseases.
Article
Biochemistry & Molecular Biology
Oluwanifemi Esther Bolatimi, Kimberly Z. Head, Jianzhu Luo, Tyler C. Gripshover, Qian Lin, Ngozi V. Adiele, Walter H. Watson, Caitlin Wilkerson, Lu Cai, Matthew C. Cave, Jamie L. Young
Summary: The pathogenesis of NAFLD is associated with zinc deficiency. Zinc supplementation does not have therapeutic effects on established NAFLD. Our study suggests that 8-week zinc supplementation cannot reverse established NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Guangwen Yan, Shuaibing Li, Yuhang Wen, Yadan Luo, Jingrong Huang, Baoting Chen, Shuya Lv, Lang Chen, Lvqin He, Manli He, Qian Yang, Zehui Yu, Wudian Xiao, Yong Tang, Weiyao Li, Jianhong Han, Fangfang Zhao, Shumin Yu, Fang Kong, Benazir Abbasi, Hongmei Yin, Congwei Gu
Summary: This study found that the diversity and relative abundance of microbiota in the jejunum, ileum, cecum, and colon were significantly changed in NAFLD mice, except for the jejunum. Therefore, the results of cecal and colonic microbiota cannot fully represent the microbiota of the jejunum and ileum.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhi-Tong Zhang, Wen-Jiao He, Si-Min Deng, Shu-Hong Xu, Xia Zeng, Zheng-Ming Qian, Zhi-Quan Chen, Shu-Mei Wang, Dan Tang
Summary: The study found that trilobatin can alleviate liver injury in diabetic mice with NAFLD by suppressing NLRP3 inflammasome activation, improving liver function, and reducing lipid accumulation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Daixi Jiang, Jianbin Zhang, Shuangzhe Lin, Yuqin Wang, Yuanwen Chen, Jiangao Fan
Summary: The gut-liver axis plays a role in NAFLD, and PREP disruption can modulate gut microbiota composition and reduce inflammation in the liver. Additionally, PREP disruption may have a therapeutic potential in targeting hepatic mechanisms related to liver, gut, and microbiota during NAFLD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Xiwei He, Jinhong Jiang, Xu-Xiang Zhang
Summary: This study investigates the impact of chronic exposure to low-dose PFHxS on NAFLD and metabolic functions. The results showed that PFHxS exposure significantly promoted obesity and metabolic syndrome, aggravated NAFLD symptoms, and caused gut dysbiosis as well as alterations in key genes. These findings suggest that environmental PFHxS exposure is an important risk factor for metabolic diseases, especially among obese individuals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Linyu Zhang, Xin Li, Xiangyan Liu, Xiaoran Wu, Qiurong Xu, Jianyu Qu, Xiaowen Li, Yuanyuan Zhu, Lixin Wen, Ji Wang
Summary: This study compared the effects of high-fat, high-calorie diets and high-carbohydrate, low-fat diets on glucose-lipid metabolism in mice. High-fat diets led to obesity and hepatic lipid deposition, while high-carbohydrate diets induced cholesterol deposition in the liver. Optimal metabolic homeostasis in mice was observed with a diet containing 25% fat.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Songling Jiang, Md Jamal Uddin, Xiaoying Yu, Lingjuan Piao, Debra Dorotea, Goo Taeg Oh, Hunjoo Ha
Summary: The study demonstrated that using the PPARα agonist fenofibrate effectively prevented HFD-induced NAFLD, increased the expression of peroxisomal genes and proteins, and restored the impaired peroxisomal fatty acid oxidation induced by HFD, highlighting the functional significance of peroxisomal fatty acid oxidation in the protective effect of fenofibrate against NAFLD.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mingyao Sun, Yeyi Gu, Shannon L. Glisan, Joshua D. Lambert
Summary: Cocoa supplementation has hepatoprotective effects in obese mice with high-fat diet-induced NAFLD, reducing body weight gain, hepatic triacylglycerols, lipid peroxides, and mitochondrial DNA damage while increasing hepatic superoxide dismutase and glutathione peroxidase enzyme activity. These effects are likely related to SIRT3/PGC1a-mediated increases in antioxidant response and mitochondrial biogenesis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yo Na Kim, Jae Hoon Shin, Dong Soo Kyeong, Soo Young Cho, Mi-Young Kim, Hee Jung Lim, Maria Raquel Rojas Jimenez, Il Yong Kim, Mi-Ock Lee, Yun Soo Bae, Je Kyung Seong
Summary: Research has shown that AHNAK protein can regulate adipocyte development and prevent fatty acid accumulation, potentially contributing to the treatment of nonalcoholic fatty liver disease (NAFLD).
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Hui Zhao, Xiang Gao, Zhizuo Liu, Lei Zhang, Xuan Fang, Jianping Sun, Zhaofeng Zhang, Yongye Sun
Summary: This study found that sodium alginate has a preventive effect on non-alcoholic fatty liver disease (NAFLD) and this effect is achieved through the modulation of the gut-liver axis. Sodium alginate can reduce body weight, hepatic steatosis, serum lipid levels, inflammatory markers, and improve the composition of gut microbiota and metabolites associated with NAFLD.
Article
Biochemistry & Molecular Biology
Lun Hua, Jing Li, Yi Yang, Dandan Jiang, Xuemei Jiang, Xingfa Han, Jin Chao, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Jian Li, Zhengfeng Fang, Mengmeng Sun, Senyan Du, Ting Luo, De Wu, Yong Zhuo
Summary: The role of liver FGF21 and the mechanisms underlying the protective effects of time-restricted feeding (TRF) in nonalcoholic fatty liver disease (NAFLD) were studied. TRF prevented body weight gain, improved glucose homeostasis, and protected against high-fat diet-induced hepatosteatosis and liver damage. However, these beneficial effects of TRF were blunted in mice lacking liver FGF21.
Article
Agriculture, Dairy & Animal Science
Ce Qi, Mengfan Ding, Shuangqi Li, Qin Zhou, Duo Li, Renqiang Yu, Jin Sun
Summary: This study investigated the probiotic role of breast milk-derived Lactobacillus reuteri FN041 in immune development in mice. Results showed that FN041 positively influenced intestinal immune barriers, especially in female mice, and regulated the expression of immunoglobulin A and related genes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Kelei Li, Xianfeng Shao, Huiying Li, Xiaotong Kuang, Xiaolei Song, Yan Wang, Suqin Zhu, Duo Li
Summary: This study found that a combination of folic acid and n-3 polyunsaturated fatty acids has a better preventive effect on neural tube defects induced by maternal diabetes compared to folic acid alone. The combination treatment reduced neuroepithelial cell apoptosis and regulated the expression of key genes involved in diabetes-induced defects. The combination therapy also attenuated diabetes-induced hypermethylation and overexpression of genes related to one-carbon metabolism and lowered levels of homocysteine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xiaotong Kuang, Kelei Li, Yan Shi, Xianfeng Shao, Huiying Li, Duo Li
Summary: The effects of dietary fiber on obesity-related traits have shown inconsistent results in previous studies. This study aimed to investigate whether genetic variants related to satiety and appetite can modify the impact of dietary fiber on obesity-related traits. The findings revealed that defatted flaxseed flour biscuits significantly reduced body weight and BMI in A-allele carriers of the FTO gene, but not in non-carriers. The biscuits also had a greater impact on fasting serum glucose reduction in participants with the CC genotype of the NPY gene compared to those with the TC and TT genotypes. Additionally, the presence of the T allele of the PCSK1 gene and the A allele of the BDNF gene increased the effectiveness of defatted flaxseed flour in reducing body weight and BMI. These results suggest that genetic variants related to satiety and appetite can modulate the effects of dietary fiber on obesity-related traits.
Article
Biochemistry & Molecular Biology
Kelei Li, Huiying Li, Xiaolei Song, Xiaotong Kuang, Shiyi Liu, Suqing Zhu, Duo Li
Summary: The present study investigated the preventive effect of mussel oil (MO) on gestational diabetes mellitus (GDM) in mice fed a high-fat and high-sucrose (HFHS) diet. Results showed that the MO group had lower AUC for OGTT and ITT compared with the control group. In addition, the MO group exhibited lower insulin resistance and fasting serum insulin levels, as well as higher levels of SphK2, Akt, and P-Akt in the liver. Overall, mussel oil showed better effects in improving glucose intolerance and insulin resistance during pregnancy compared to fish oil.
Review
Nutrition & Dietetics
Andrew J. Sinclair, Yonghua Wang, Duo Li
Summary: DHA is crucial for neural and visual function, but there is limited evidence to support the claim that low DHA levels are associated with child development disorders and neurological conditions.
Article
Food Science & Technology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Kelei Li, Yinpeng Wang, Ruirui Liu, Yanjun Guo, Duo Li
Summary: This study aimed to assess the effects of blend oil on liver function markers in healthy subjects. The results showed that blend oil was more effective in reducing liver function markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) compared with soybean oil or lard alone. This suggests that blend oil may be beneficial for preventing non-alcoholic fatty liver disease in the healthy population.
Article
Biochemistry & Molecular Biology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Haichao Wen, Yanjun Guo, Duo Li
Summary: The study found that blend oil (lard plus soybean oil) is more beneficial for body weight and liver function compared to the individual use of lard and soybean oil. It also reduces cardiometabolic risk factors in healthy subjects.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Chang Liu, Tianyu Zhang, Runjia Shi, Xinqi Wang, Huina Xu, Duo Li
Summary: The aim of this study was to investigate the preventive effect of soy protein and whey protein on high-fat diet-induced insulin resistance and its potential molecular mechanisms. The results showed that compared with the whey protein group, the soy protein group had significantly lower insulin concentration, insulin resistance, and liver weight. Furthermore, the expression levels of lipid metabolism-related genes in the liver, as well as the expression levels of glucose transport proteins and insulin receptor signaling pathway proteins in the liver and muscle, were significantly altered in the soy protein group. Additionally, the composition of gut microbiota was also changed in the soy protein group.
Article
Biochemistry & Molecular Biology
Xiangyuan Meng, Chunyan Tian, Chenqi Xie, Hao Zhang, Haoyu Wang, Mai Zhang, Zhenquan Lu, Duo Li, Lei Chen, Tianlin Gao
Summary: Obesity can greatly impair skeletal muscle function, but punicalagin (PUN) can prevent obesity-induced skeletal muscle dysfunction by regulating TET2. PUN supplementation increases muscle weight, grip strength, and muscle fiber count in obese mice. Additionally, PUN enhances the stability of TET2 protein and increases its demethylation activity.
Review
Biochemistry & Molecular Biology
Yi Ren, Fuhuai Jia, Duo Li
Summary: Instant powder foods are widely used in various food sectors and have the potential to provide health benefits with functional or beneficial compounds. The design of instant powder foods can be challenging due to their complex structures and flexible formulations. This review proposes a new classification method based on ingredient solubility and reconstituted product structure. The structure of instant powder foods is significantly influenced by their ingredients.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Tianyu Zhang, Runjia Shi, Xinqi Wang, Yan Wang, Huina Xu, Duo Li
Summary: The study found that whey protein was more effective than soy protein in preventing obesity, possibly by suppressing lipogenesis, activating brown adipose tissue, and promoting browning of inguinal white adipose tissue. In addition, lowering the protein-to-carbohydrate ratio was beneficial for combating obesity.
Article
Biochemistry & Molecular Biology
Shan Li, Mengli Li, Ronghua Guo, Ting Zhao, Xiang Gao, Kelei Li, Xiaofei Guo, Junhui Li, Duo Li
Summary: The study found that fucoidans extracted from sea cucumber Pearsonothuria graeffei (fuc-Pg) can prevent obesity and systemic inflammation through multiple mechanisms. Adding fuc-Pg significantly reduces weight gain and fat accumulation caused by a high-fat diet, improves serum lipid profile, reverses intestinal and white adipose tissue abnormalities induced by a high-fat diet, and reduces systemic inflammation.
Article
Biochemistry & Molecular Biology
Ze-Kai Fan, Wen-Jun Ma, Wei Zhang, Hui Li, Jie Zhai, Ting Zhao, Xiao-Fei Guo, Andrew J. Sinclair, Duo Li
Summary: This study investigated the relationship between changes in serum lipid metabolites and risk factors of NAFLD after fish oil or fish oil plus vitamin D intervention. The results showed that serum levels of phosphatidylcholine (PC) (16:1/22:6) were increased after interventions. These levels were correlated with liver function, lipid metabolism, and inflammation markers in NAFLD subjects.
Article
Biochemistry & Molecular Biology
Zekai Fan, Chong Wang, Ting Yang, Tianlin Gao, Dan Wang, Xiaoyan Zhao, Xiaofei Guo, Duo Li
Summary: Coffee peel extracts containing caffeine and seven monomers of flavonoids can protect against NAFLD by regulating the FGF21-adiponectin signaling pathway.
Article
Biochemistry & Molecular Biology
Xiang Gao, Huijun Zhang, Kelei Li, Yan Shi, Xiaofei Guo, Ling Wang, Duo Li
Summary: The study showed that the prevention effect of Sandalwood seed oil on insulin resistance induced by a high-fat/high-sucrose diet was associated with altered intestinal microbiota composition and the production of microbial metabolites.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.