Article
Immunology
Chao Jia, Fei Hu, Di Lu, Haidong Jin, Hongwei Lu, Enxing Xue, Dengying Wu
Summary: Formononetin has anti-inflammatory properties and exhibits protective effects in osteoarthritis, suggesting its potential as a therapeutic agent for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chao Tan, Huasheng Du, Yang Wang, Jianjun Zhao, Xiaolong Cheng, Haihe Lan
Summary: This study found that the expression levels of GABPB1-IT1 were downregulated in ccRCC and predicted poor survival. GABPB1-IT1 directly interacted with miR-21 and inhibited ccRCC cell proliferation by upregulating PTEN expression through sequestering miR-21.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Chen Yang, Zezhong Mou, Zheyu Zhang, Siqi Wu, Quan Zhou, Yiling Chen, Jian Gong, Chenyang Xu, Yuxi Ou, Xinan Chen, Xiyu Dai, Haowen Jiang
Summary: Our study revealed the tumor suppressive role of circRBPMS in bladder cancer by targeting the miR-330-3p/RAI2 axis, leading to inhibition of cell proliferation and metastasis. Downregulation of circRBPMS is associated with aggressive bladder cancer, while upregulation can suppress cell proliferation and migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Dexiang Feng, Jiancheng Lv, Kai Li, Qiang Cao, Jie Han, Hao Yu, Yidong Cheng, Juntao Zhuang, Lingkai Cai, Haiwei Yang, Xiao Yang, Qiang Lu
Summary: Studies have shown that circZNF609, a circular RNA, is significantly upregulated in bladder cancer and is associated with poor patient survival. Overexpression of circZNF609 promotes bladder cancer cell proliferation, migration, and resistance to cisplatin chemotherapy. Mechanistically, circZNF609 acts as a sponge for miR-1200, alleviating its inhibitory effect on the target gene CDC25B. These findings suggest that circZNF609 has significant potential as a new diagnostic biomarker and therapeutic target in bladder cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell & Tissue Engineering
Yinglang Zhang, Zhi Li, Yu Zhang, Chong Shen, Zhe Zhang, Xiaolei Ren, Changgang Guo, Shaobo Yang, Zejin Wang, Hailong Hu
Summary: This article identifies a novel circRNA, circSOBP, and explores its expression and association with clinicopathological features and prognosis in bladder cancer patients. Results show that circSOBP expression is downregulated in bladder cancer tissues and cell lines, and lower expression is associated with advanced stage, larger tumors, and poorer survival. In vitro and in vivo experiments demonstrate that circSOBP inhibits cell proliferation, migration, and invasion. Mechanistically, circSOBP competitively interacts with miR-200a-3p to enhance PTEN expression. The study suggests circSOBP as a potential biomarker and therapeutic target for bladder cancer.
CELL TRANSPLANTATION
(2023)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Biochemistry & Molecular Biology
Hui Huang, Xia Li, Xianlin Zhang, Zhiqiang Li, Duo Han, Wenzhe Gao, Ling Liu, Cheng Peng, Hongwei Zhu, Xiao Yu
Summary: The DSCR9/miR-21-5p/BTG2 axis regulates the proliferation, invasion, and gemcitabine resistance of pancreatic cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Jing Zhou, Ning Ma, Weiying Lu, Zhi Zhou, Suju Liu
Summary: The purpose of this study was to screen micro-ribonucleic acids (miRNAs) in the pathological processes of preeclampsia (PE) and evaluate their effects on HTR-8/SVneo cell proliferation and apoptosis. MiRNAs in PE patients and healthy puerperae were screened and verified. The expression level of miR-19a was found to affect HTR-8/SVneo cell proliferation, cell cycle, and apoptosis. MiR-19a targets PTEN to activate the Akt signaling pathway, promoting cell proliferation and inhibiting apoptosis. This provides potential drug targets for future treatment of PE.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Cell Biology
Lei Shi, Ying Cao, Wei Yuan, Jun Guo, Guan Sun
Summary: This study reveals that exosomes derived from RBP-J-overexpressed macrophages inhibit tumor progression in glioma cells through the circBTG2/miR-25-3p/PTEN pathway, suggesting circBTG2 as a potential diagnostic biomarker and therapeutic target for glioma.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Wenqing Li, Zihao Wang, Ziming Jiang, Yan Yan, Xiaohan Yao, Zhenzhen Pan, Lin Chen, Fei Wang, Ming Wang, Zhihai Qin
Summary: The study found that miR-3960 levels in bladder cancer tissue were positively correlated with patient survival time. miR-3960 inhibited bladder cancer growth and promoted drug-induced apoptosis by suppressing DEXI expression. These findings suggest that miR-3960 could be a potential therapeutic strategy against bladder cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Wen-Kang Chen, Han-Jing Zhang, Ming-Xiang Zou, Cheng Wang, Yi-Guo Yan, Xin-Li Zhan, Xue-Lin Li, Wen-Jun Wang
Summary: In this study, the function of lncRNA HOTAIR in the proliferation of human nucleus pulposus (NP) cells of intervertebral disc degeneration (IDD) was investigated. The results showed that HOTAIR can suppress proliferation by directly targeting miR-130b. Additionally, HOTAIR upregulation significantly reduced CyclinD1 protein expression through the PTEN/AKT signaling pathway. These findings suggest that HOTAIR may be a potential target for the treatment of IDD.
Article
Biotechnology & Applied Microbiology
Hao Jia, Wei Sun, Xiangbo Li, Wenhao Xu
Summary: MEL has been found to effectively inhibit the growth of thyroid cancer and suppress tumor cell proliferation while promoting apoptosis. MEL also regulates the expression of certain genes and proteins to further promote tumor cell apoptosis.
Article
Cell Biology
Gang Han, Quanyi Guo, Ning Ma, Wenzhi Bi, Meng Xu, Jinpeng Jia
Summary: Apatinib inhibits the proliferation and migration of osteosarcoma cells through the LINC00261/miR-620/PTEN axis, indicating its potential therapeutic efficacy.
Article
Oncology
Marta Correia de Sousa, Nicolas Calo, Cyril Sobolewski, Monika Gjorgjieva, Sophie Clement, Christine Maeder, Dobrochna Dolicka, Margot Fournier, Laurent Vinet, Xavier Montet, Jean-Francois Dufour, Bostjan Humar, Francesco Negro, Christine Sempoux, Michelangelo Foti
Summary: Despite being considered a potent oncomiR in human cancers, genetic deletion of miR-21 in mouse models surprisingly promotes hepatocellular carcinoma (HCC) development by affecting various signaling pathways and immune responses. These results challenge the current belief in miR-21 as an oncogene and raise caution regarding using miR-21 inhibition as a therapeutic approach for HCC.
Article
Nutrition & Dietetics
Yunjeong Park, Sung Pil Choo, Gee Soo Jung, Sehee Kim, Min Jung Lee, Wooseok Im, Hyemin Park, Inha Lee, Jae Hoon Lee, Sihyun Cho, Young Sik Choi
Summary: This study evaluated the effects of formononetin on endometriosis progression and found that it inhibits the proliferation of endometria in patients with endometriosis through the regulation of p27, pSTAT3, and PR-B. Formononetin treatment also significantly reduced the number of endometriotic lesions in an endometriosis mouse model. It may be a potential non-hormonal treatment option for endometriosis.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.