Article
Endocrinology & Metabolism
Zheng Zhang, Tao Lin, Yichen Meng, Miao Hu, Lun Shu, Heng Jiang, Rui Gao, Jun Ma, Ce Wang, Xuhui Zhou
Summary: This study revealed that long-term high-fat diet can lead to decreased bone mass, dysbiosis of gut microbiota, leaky gut, and systemic inflammation. Administration of fructooligosaccharides (FOS) and/or galactooligosaccharides (GOS) significantly improved bone loss, regulated imbalanced differentiation of intestinal cells, reduced dysbiosis and gut permeability, decreased expression of inflammatory cytokines, ultimately protecting against high-fat diet-induced osteopenia.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Laura Nickel, Annika Suenderhauf, Elias Rawish, Ines Stoelting, Stefanie Derer, Christoph Thorns, Urte Matschl, Alaa Othman, Christian Sina, Walter Raasch
Summary: The angiotensin II receptor blocker telmisartan has been found to decrease mucin thickness associated with obesity, independent of expression levels of Muc2 and goblet cells. It also decreases cell proliferation and increases necroptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mark B. Wiley, Nicholas DiPatrizio
Summary: The gut barrier is compromised in diet-induced obesity, and the dysregulated endocannabinoid system in the gut may play a role in this dysfunction. This study found that mice lacking cannabinoid receptor subtype-1 (CB1R) in intestinal epithelial cells had worsened gut barrier dysfunction when fed a high-fat/sucrose diet. The mice also showed reduced levels of endocannabinoids and altered gene expression for gut barrier components and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Chen-Jie Ling, Xiao-Fang Chen, Jia-Ying Xu, Gui-Ping Wang, Yan Wang, Yue Sun, Yun-Liang Li, Zhong-Xiao Wan, Xing Tong, Khemayanto Hidayat, Wan-Zhan Zhu, Li-Qiang Qin, Jing Yang
Summary: Whey protein hydrolysates have good prospects in weight management for middle-aged individuals by reducing energy intake, slowing down weight gain, improving blood lipids and glucose, and enhancing muscle antioxidant capacity.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Gang Wu, Xiaodan Hui, Xi Gong, Khan Nhu Tran, Letitia Stipkovits, Maneesha S. Mohan, Margaret A. Brennan, Charles S. Brennan
Summary: Whey proteins and dietary phenolics can interact fully under different pH conditions, forming complexes that improve the bioaccessibility and bioavailability of phenolics. Combination of whey proteins with dietary phenolics at both molecular and mixture levels creates novel functional ingredients.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zuolin Ma, Fumei Zhang, Hongxin Ma, Xinghao Chen, Jiaqing Yang, Yiyan Yang, Xueying Yang, Xiaojing Tian, Qunli Yu, Zhongren Ma, Xueyan Zhou
Summary: This study used D-galactose-treated aging mice models to investigate the effects of different animal sources and doses of whey protein (WP) on immune indexes, organs, and intestinal flora. It found that WP intervention improved weight gain, thymus ratio, antioxidant capacity, and some immune indicators in aging mice. Lactobacillus may play a positive role in functional repair, while Stenotrophomonas may have a negative impact on immune and antioxidant capacity. Low-concentration WP from cow and goat may be optimal for aging models.
Article
Pharmacology & Pharmacy
Jessica Latorre, Aina Lluch, Francisco J. Ortega, Aleix Gavalda-Navarro, Ferran Comas, Samantha Moron-Ros, Amaia Rodriguez, Sara Becerril, Francesc Villarroya, Gema Fruhbeck, Wifredo Ricart, Marta Giralt, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: The study found that lysozyme is highly expressed in adipose tissue of obese individuals, associated with chronic inflammation, adipose tissue inflammation, and metabolic disturbances. Knocking down the lysozyme gene in experimental models improved adipose tissue inflammation and reduced weight gain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Microbiology
Savanna N. Weninger, Chloe Herman, Rachel K. Meyer, Eve T. Beauchemin, Archana Kangath, Adelina I. Lane, Taylor M. Martinez, Tahia Hasneen, Sierra A. Jaramillo, Jason Lindsey, Gayatri Vedantam, Haijiang Cai, Emily K. Cope, J. Gregory Caporaso, Frank A. Duca
Summary: This study shows that oligofructose (OFS) supplementation can modulate the small intestinal microbiota and improve lipid sensing mechanisms in the small intestine, leading to decreased food intake and improved energy homeostasis. The alterations to the microbiota induced by OFS treatment play a key role in regulating food intake and energy balance.
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maria Chiara Valerii, Silvia Turroni, Carla Ferreri, Michela Zaro, Anna Sansone, Alessandro Dalpiaz, Giada Botti, Luca Ferraro, Renato Spigarelli, Irene Bellocchio, Federica D'Amico, Enzo Spisni
Summary: Studies have shown that D-Limonene can improve metabolic parameters in obese mice via various mechanisms, including modulation of intestinal microbiota. Administering a food supplement containing D-Limonene adsorbed on dietary fibers to mice on a high-fat diet led to decreased weight gain and improved metabolic profile, highlighting the potential non-toxic and effective use of this supplement in combating obesity.
Article
Biology
Maria J. Duque-Correa, Daryl Codron, Carlo Meloro, Amanda McGrosky, Christian Schiffmann, Mark S. Edwards, Marcus Clauss
Summary: It is often believed that herbivores have longer intestinal tracts than carnivores, but statistical methods have not yet proven this link. Body mass is more closely related to small intestine length, except for the caecum in smaller species. Diet has a main effect on the components of the large intestine, and habitat aridity is positively related to large intestine length.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dan Liang, Liang Zhang, Hongzhu Chen, Hong Zhang, Honghai Hu, Xiaofeng Dai
Summary: Potato resistant starch type 3 (PRS) can regulate high fat diet-induced metabolic syndrome, promote intestinal cell proliferation, reduce Firmicutes/Bacteroidetes ratio, regulate intestinal microbiota abundance and metabolites, and are associated with anti-obesity potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Z. H. Miao, W. X. Zhou, R. Y. Cheng, H. J. Liang, F. L. Jiang, X. Shen, J. H. Lu, M. Li, F. He
Summary: The study suggests that early exposure to ceftriaxone may worsen the negative impacts of a high-fat diet on host physiology, while orally fed TMC3115 has a protective effect. The crosstalk between the host and their intestinal microbiota in early life seems to play a crucial role in metabolism regulation.
Article
Biochemistry & Molecular Biology
Yu-Ju Lin, Yingjia Chen, Tai L. Guo, Fanbin Kong
Summary: This study compared the short-term effects of CNF, CNC, and Tempo-CNF on mice fed a high-fat and high-sugar diet and found no significant effects when combined with a sub-optimal diet.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Dagmara Zlotkowska, Emilia Stachurska, Ewa Fuc, Barbara Wroblewska, Anita Mikolajczyk, Ewa Wasilewska
Summary: The study showed diverse immunomodulatory effects between beta-lactoglobulin (beta-lg) and kappa-casein (kappa-CN), with beta-lg being more immunogenic and triggering a stronger Th1 response, while kappa-CN induced significantly higher IgE response. Interaction risks between immune responses to different milk proteins were observed, which could exacerbate allergies, particularly those caused by beta-lg.
Article
Biochemistry & Molecular Biology
Ewa Fuc, Dagmara Zlotkowska, Ewa Wasilewska, Barbara Wroblewska
Summary: The transfer of OVA-experienced CD4(+) T cells ameliorated the negative immune response to OVA in mice with chicken meat allergy, indicating the potential role of specific T cells in food allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemical Research Methods
Annelein Meisner, Beatrix Wepner, Tanja Kostic, Leo S. van Overbeek, Christine J. Bunthof, Rafael Soares Correa de Souza, Marta Olivares, Yolanda Sanz, Lene Lange, Doreen Fischer, Angela Sessitsch, Hauke Smidt
Summary: Microbiomes are essential players in various ecosystems and have significant impacts on biotechnological applications and health. However, current research mostly focuses on individual ecosystems, and a systems approach is needed to fully understand and utilize microbiomes for sustainable bioeconomy.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Editorial Material
Genetics & Heredity
Tomislav Cernava, Daria Rybakova, Francois Buscot, Thomas Clavel, Alice Carolyn McHardy, Fernando Meyer, Folker Meyer, Jorg Overmann, Barbel Stecher, Angela Sessitsch, Michael Schloter, Gabriele Berg
Summary: This article introduces the key issues regarding the current system for metadata submission in omics research and proposes the development of a global metadata system. The system should be easy to use, structured in a hierarchical way, and compatible with existing microbiome data repositories. The article also emphasizes the need for greater awareness and engagement of the scientific community in international legal issues related to genetic resource and sequence sharing.
ENVIRONMENTAL MICROBIOME
(2022)
Article
Nutrition & Dietetics
Lidia Hanna Markiewicz, Anna Maria Ogrodowczyk, Wieslaw Wiczkowski, Barbara Wroblewska
Summary: Phytic acid is found in cereal seeds and legumes, and its degradation by gut microbiota is more efficient in vegans compared to omnivores. This study investigates the immune response of colonocytes treated with phytic acid hydrolysate and gut bacteria.
Article
Nutrition & Dietetics
Barbara Wroblewska, Ewa Kubicka, Ewelina Semenowicz, Anna Ogrodowczyk, Anita Mikolajczyk, Dagmara Zlotkowska
Summary: Barley proteins are similar to wheat proteins and can cause allergic reactions. The 15-kDa fraction (B-FrVI) of barley proteins showed the strongest immune response. In a mouse model, B-FrVI protein significantly enhanced specific immune responses and stimulated lymphocyte proliferation.
Article
Agriculture, Dairy & Animal Science
Anna Maria Ogrodowczyk, Maja Jez, Barbara Wroblewska
Summary: Breastfeeding has benefits for infants, with the microbiota and proteins playing important roles in immune responses and bioactivity, warranting further research.
Article
Agriculture, Dairy & Animal Science
Beata Nalepa, Lidia Hanna Markiewicz
Summary: Traditional and regional cheeses are gaining popularity among consumers, but their unique microbiota may lead to antibiotic resistance. This study aimed to investigate the microbial diversity of regional cheeses made from cow, goat, and ewe milk and determine the antibiotic resistance of lactic acid bacteria. Conventional microbiological and PCR methods were used, and multiple antibiotic resistance genes were found in the lactic acid bacteria.
Review
Biochemistry & Molecular Biology
Joanna Fotschki, Anna M. M. Ogrodowczyk, Barbara Wroblewska, Jerzy Juskiewicz
Summary: The vegetable processing industry generates large amounts of by-products that are susceptible to microbial degradation. Inadequate management leads to the loss of valuable compounds in vegetable by-products. Scientists are exploring the possibility of reusing discarded biomass to create higher value products. The by-products contain bioactive compounds with health-promoting properties. This review emphasizes the importance of these by-products in promoting health through their impact on the microbiota, immune system, and gut milieu.
Editorial Material
Agriculture, Dairy & Animal Science
Anna Maria Ogrodowczyk, Monika Modzelewska-Kapitula
Review
Microbiology
Angela Sessitsch, Steve Wakelin, Michael Schloter, Emmanuelle Maguin, Tomislav Cernava, Marie-Christine Champomier-Verges, Trevor C. Charles, Paul D. Cotter, Ilario Ferrocino, Aicha Kriaa, Pedro Lebre, Don Cowan, Lene Lange, Seghal Kiran, Lidia Markiewicz, Annelein Meisner, Marta Olivares, Inga Sarand, Bettina Schelkle, Joseph Selvin, Hauke Smidt, Leo van Overbeek, Gabriele Berg, Luca Cocolin, Yolanda Sanz, Wilson Lemos Fernandes, S. J. Liu, Matthew Ryan, Brajesh Singh, Tanja Kostic
Summary: Microbiomes play crucial roles in ecosystem functioning, supporting planetary health through nutrient cycling, climate regulation, and water filtration. They are closely associated with complex multicellular organisms and contribute to the health of their hosts. However, there is still limited understanding of microbiome transfer and connectivity.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Nutrition & Dietetics
Dagmara Zlotkowska, Mateusz Kuczynski, Ewa Fuc, Joanna Fotschki, Barbara Wroblewska
Summary: This study aimed to evaluate the effect of glycation on the ex vivo response of beta-lactoglobulin sensitized lymphocytes. Results showed that glycation does not reduce the immunogenicity of the protein.
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.