Article
Chemistry, Medicinal
Changzhi Wang, Meiyier Huandike, Yingxia Yang, Huijie Zhang, Guiyu Feng, Xiaoying Meng, Pingxin Zhang, Juan Liu, Jinyu Li, Limin Chai
Summary: The study evaluated the mechanism of glycosides from Caulis Lonicerae in inhibiting inflammatory proliferation of FLS induced by IL-1β, finding that it restored T cell balance and suppressed JAK-STAT and NF-kappa B signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Genetics & Heredity
Ezio T. Fok, Simone J. C. F. M. Moorlag, Yutaka Negishi, Laszlo A. Groh, Jessica Cristina dos Santos, Cathrin Graewe, Valerie Villacorta Monge, Daphne D. D. Craenmehr, Mellanie van Roosmalen, David Pablo da Cunha Jolvino, Leticia Busato Migliorini, Ary Serpa Neto, Patricia Severino, Michiel Vermeulen, Leo A. B. Joosten, Mihai G. Netea, Stephanie Fanucchi, Musa M. Mhlanga
Summary: Inflammation is a biphasic cycle involving proinflammatory and anti-inflammatory processes. IL-1 beta and IL-37 are two cytokines encoded within the same topologically associating domain (TAD) and their expression is regulated by a long noncoding RNA called AMANZI. AMANZI downregulates IL-1 beta expression and trained immunity by inducing IL-37 transcription via long-range chromatin contacts.
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou
Summary: Research has shown that Ginkgolide J (GJ) can significantly reduce the excessive production of pro-inflammatory mediators in SW982 cells induced by LPS, by targeting p38 signaling pathway. This suggests that GJ may have a potential therapeutic effect in preventing and treating rheumatoid arthritis by suppressing inflammatory responses.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Yang Song, Xinyu Xing, Jing Shen, Guo Chen, Li Zhao, Lu Tian, Jie Ying, Yongqiang Yu
Summary: This study discussed the effects of Glycyrrhetinic acid on the expression of inflammatory factors in IL-1β-induced SW982 cells and its anti-inflammatory effects. MTT results showed that Glycyrrhetinic acid (<= 80 mu mol center dot L 1) had low toxicity on SW982 cells. ELISA and real-time PCR results demonstrated that Glycyrrhetinic acid (10, 20 and 40 mu mol center dot L-1) significantly inhibited the expression of inflammatory factors such as IL-6, IL-8, and MMP-1. Furthermore, Glycyrrhetinic acid exhibited therapeutic effects on adjuvant-induced arthritis (AIA) in rats in vivo. Overall, these findings suggest that Glycyrrhetinic acid has potential as an anti-inflammatory agent and should be further investigated.
Article
Biology
Zihao Yao, Weizhong Qi, Hongbo Zhang, Zhicheng Zhang, Liangliang Liu, Yan Shao, Hua Zeng, Jianbin Yin, Haoyan Pan, Xiongtian Guo, Anling Liu, Daozhang Cai, Xiaochun Bai, Haiyan Zhang
Summary: Obesity is a significant risk factor in the progression of osteoarthritis (OA), but the mechanism of obesity-related inflammation in OA synovitis is not fully understood. This study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the important role of M1 macrophages in impaired macrophage efferocytosis. The study revealed that obese OA patients and Apoe(-/-) mice showed more severe synovitis and increased macrophage infiltration, accompanied by dominant M1 macrophage polarization.
Article
Cell Biology
Ming-Lung Hsu, Wen-Chung Huang, Yi-Rong Zhou, Sindy Hu, Chun-Hsun Huang, Shu-Ju Wu
Summary: Oleuropein demonstrates potential in attenuating IL-1 beta-induced inflammation in adult RPE cells by inhibiting NF-kappa B and MAPK signaling pathways, reducing secretion of inflammatory cytokines, and showing anti-inflammatory effects. The results suggest that oleuropein may be useful in the prevention and treatment of inflammatory diseases in the retina.
Article
Cell & Tissue Engineering
Mijin Kim, Dong Il Shin, Byung Hyune Choi, Byoung-Hyun Min
Summary: The study showed that MSC exosomes primed with IL-1 beta exhibit significantly enhanced anti-inflammatory activity in osteoarthritic SW982 cells. This effect is mediated by miRNAs such as miR-147b and involves inhibition of the NF-kappa B pathway. Additionally, the presence of miR-147b in MSC-IL-Exo plays a crucial role in the regulation of inflammatory cytokines.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Orthopedics
Hai Wang, Leilei Qin, Jiawei Wang, Wei Huang
Summary: The study demonstrates the valuable role of synovial fluid IL-1 beta in diagnosing chronic PJI, with the combined measurement of IL-1 beta and PMN% leading to increased specificity.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Immunology
Jose L. Arias, Samanta C. Funes, Rodrigo Blas, Eduardo Callegari, Ricardo J. Elicabe, Maria D. Paez, Alicia Munarriz, Rodolfo Pardo-Hidalgo, Hector Tamashiro, Maria S. Di Genaro
Summary: The study found a significant relationship between S100A8 alarmin and IL-6 and MMP-9 secretion in the synovial microenvironment of peripheral SpA, revealing the involvement of S100A8 in the pathogenesis of peripheral SpA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mater Hussen Mahnashi, Zeeshan Jabbar, Alamgeer, Hafiz Muhammad Irfan, Mulazim Hussain Asim, Muhammad Akram, Ahmed Saif, Mohammed Abdulrahman Alshahrani, Mohammed Ali Alshehri, Saeed Ahmed Asiri
Summary: The study demonstrated that venlafaxine exhibits significant anti-arthritic activity by reducing inflammation, improving pathological indicators, and alleviating pain associated with arthritis.
INFLAMMOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ana Teresa Rufino, Mariana Lucas, Artur M. S. Silva, Daniela Ribeiro, Eduarda Fernandes
Summary: The study found that 2-SC can reduce oxidative stress and inflammation in rheumatoid arthritis by inhibiting the NF-kappa B pathway. However, one of the 2-SC also has the ability to suppress the NF-kappa B pathway, further reducing the expression of inflammatory factors. These results suggest that 2-SC may be potential drugs for new therapeutic strategies for rheumatoid arthritis.
Article
Oncology
Jun Zhang, Lingfeng Fu, Noriko Yasuda-Yoshihara, Atsuko Yonemura, Feng Wei, Luke Bu, Xichen Hu, Takahiko Akiyama, Fumimasa Kitamura, Tadahito Yasuda, Takashi Semba, Tomoyuki Uchihara, Rumi Itoyama, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Masakazu Yashiro, Yoshihiro Komohara, Hideo Baba, Takatsugu Ishimoto
Summary: The mutual activation mechanism underlying diffuse-type gastric cancer (DGC) progression was investigated through co-culture analysis and RNA sequencing, revealing the existence of mixed-polarized macrophages as a novel subtype that interacts with DGC cells and nonmalignant cells.
Article
Food Science & Technology
Chin-Horng Su, Chih-Yang Lin, Chun-Hao Tsai, Hsiang-Ping Lee, Lun-Chien Lo, Wei-Chien Huang, Yang-Chang Wu, Ching-Liang Hsieh, Chih-Hsin Tang
Summary: Betulin has shown potential for the treatment of osteoarthritis by suppressing the production of inflammatory cytokines in synovial tissue through inhibition of MEK, ERK, and NF-κ B signaling cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Physical
Aila Jimenez-Ruiz, Rafael Prado-Gotor, Jose G. Fernandez-Bolanos, Alejandro Gonzalez-Benjumea, Jose Maria Carnerero
Summary: Stable oleuropein-coated gold nanoparticles were synthesized in aqueous media for the first time. The concentration of oleuropein in the reaction medium was found to significantly impact the outcome and stability of the resulting nanocolloid, with smaller particle sizes observed in more concentrated solutions. Self-assembled structures of oleuropein were identified at a specific concentration threshold, contributing to both increased stability and reduced particle size in concentrated solutions.
Article
Nutrition & Dietetics
Maria Luisa Castejon, Catalina Alarcon-de-la-Lastra, Maria Angeles Rosillo, Tatiana Montoya, Jose G. Fernandez-Bolanos, Alejandro Gonzalez-Benjumea, Marina Sanchez-Hidalgo
Summary: Both Per-OL and OL diets showed significant protection against histological damage and arthritis development, with improvements in serum COMP, MMP-3, and pro-inflammatory cytokines levels in paws of secoiridoids fed animals. The kinase and NF-kappa B activations were down-regulated while Nrf2 and HO-1 protein expressions were up-regulated in mice fed with OL and Per-OL diets.
Article
Pharmacology & Pharmacy
Isabel Villegas, Maria Angeles Rosillo, Catalina Alarcon-de-la-Lastra, Victoria Vizquez-Romin, Maria Llorente, Susana Sanchez, Ana Gloria Gil, Pilar Alcalde, Esther Gonzalez, Elisabet Rosell, Carles Nieto, Francisco Fernandez-Campos
Summary: An innovative mucoadhesive system loaded with amoxicillin and clarithromycin is proposed to improve the efficacy against H. pylori; the treatment demonstrated superiority in bacterial count reduction and tissue evaluation; the approach proved to be efficacious and safe, presenting a realistic alternative for patient compliance and bacterial resistance reduction.
Article
Biotechnology & Applied Microbiology
Alejandro Gonzalez-Benjumea, Gisela Marques, Owik M. Herold-Majumdar, Jan Kiebist, Katrin Scheibner, Jose C. del Rio, Angel T. Martinez, Ana Gutierrez
Summary: Enzymatic conversion of vegetable oils into epoxide derivatives shows potential for industrial applications, with different peroxygenases demonstrating varying oxygenation selectivities. The enzymes exhibit high selectivity towards epoxidation, forming pure epoxides, hydroxylated derivatives, and triepoxides depending on the specific fatty acids present in the oils. This environmentally friendly approach offers promising opportunities for the production of reactive fatty-acid epoxides.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Montoya, Marina Sanchez-Hidalgo, Maria Luisa Castejon, Maria Angeles Rosillo, Alejandro Gonzalez-Benjumea, Catalina Alarcon-de-la-Lastra
Summary: The study demonstrates that dietary supplementation of Oleocanthal can prevent collagen-induced arthritis in a murine model by reducing inflammation and providing protective antioxidant effects. Oleocanthal regulates the production of inflammatory and oxidative mediators, potentially serving as a novel dietary tool for preventing autoimmune and inflammatory disorders such as rheumatoid arthritis.
Review
Nutrition & Dietetics
Tatiana Montoya, Maria Luisa Castejon, Rocio Munoz-Garcia, Catalina Alarcon-de-la-Lastra
Summary: Epigenetic modifications play a crucial role in the development and predisposition of autoimmune diseases, such as systemic lupus erythematosus (SLE). Environmental factors can affect gene expression through epigenetic mechanisms, and diet is one of the most important factors that can influence these alterations. Understanding the cross-link between epigenetic mechanisms, SLE, and dietary factors may lead to novel personalized therapies for SLE patients.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Montoya, Catalina Alarcon-de-la-Lastra, Maria Luisa Castejon, Juan Ortega-Vidal, Joaquin Altarejos, Marina Sanchez-Hidalgo
Summary: This study explores the antioxidant and anti-inflammatory effects of (-)-methyl-oleocanthal (met-OLE), a metabolite of extra virgin olive oil (EVOO), in murine peritoneal macrophages. It reveals that met-OLE inhibits the production of reactive oxygen species and pro-inflammatory enzymes, while upregulating anti-inflammatory markers. The study also suggests that met-OLE may contribute to the beneficial effects associated with EVOO consumption through epigenetic changes.
Article
Biochemistry & Molecular Biology
Dolores Linde, Elena Santillana, Elena Fernandez-Fueyo, Alejandro Gonzalez-Benjumea, Juan Carro, Ana Gutierrez, Angel T. Martinez, Antonio Romero
Summary: This study successfully crystallized two UPO enzymes, rMroUPO and rCviUPO, from different fungal groups through sequence optimization and Escherichia coli expression, revealing their crystal structures and dimeric protein characteristics.
Article
Biochemistry & Molecular Biology
Dolores Linde, Alejandro Gonzalez-Benjumea, Carmen Aranda, Juan Carro, Ana Gutierrez, Angel T. Martinez
Summary: Vegetable oils are valuable renewable resources for the production of bio-based chemicals and intermediates. Enzymes can be used as environmentally friendly alternatives to chemical catalysis in the epoxidation reactions of vegetable oils. By engineering the active site of the enzyme and optimizing the process, the epoxidation yield can be significantly enhanced.
Editorial Material
Biochemistry & Molecular Biology
Catalina Alarcon-de-la-Lastra
Article
Chemistry, Medicinal
Manuel Alcarranza, Isabel Villegas, Rocio Munoz-Garcia, Rocio Recio, Inmaculada Fernandez, Catalina Alarcon-de-la-Lastra
Summary: This study found that the natural enantiomer (R)-Sulforaphane (SFN) could modulate the immune response in LPS-stimulated murine macrophages and spleen cells by inhibiting oxidative stress and inflammatory factors. The effects of (R)-SFN on immune modulation may be mediated through various signaling pathways and epigenetic modifications. These findings suggest that (R)-SFN could be a promising compound for the management of immunoinflammatory diseases.
Article
Food Science & Technology
Tatiana Montoya, Marina Sanchez-Hidalgo, Maria Luisa Castejon, Maria Victoria Vazquez-Roman, Maria Alvarez de Sotomayor, Juan Ortega-Vidal, Maria Luisa Gonzalez, Catalina Alarcon-de-la-Lastra
Summary: This study aimed to evaluate the effects of OLE enriched diet on renal damage and aortic endothelial dysfunction in murine pristane-induced SLE. The results showed that dietary OLE supplementation reduced pro-inflammatory cytokines production, alleviated renal damage, and improved aortic endothelial dysfunction by regulating multiple signaling pathways. These preliminary results suggest OLE as a new therapeutic strategy in SLE management.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Maria Luisa Castejon, Tatiana Montoya, Juan Ortega-Vidal, Joaquin Altarejos, Catalina Alarcon-de-la-Lastra
Summary: The study evaluated the immunomodulatory and anti-inflammatory effects of Ligstroside aglycon (LA) on murine peritoneal macrophages and identified the potential signaling pathways involved. LA showed significant antioxidant and anti-inflammatory effects by reducing oxidative stress markers such as NO production and protein expression. LA was also able to modulate pro-inflammatory cytokine levels and inhibit the activation of certain signaling pathways. The study suggests that LA has potential as a natural agent for the treatment of immune-inflammatory diseases.
Meeting Abstract
Orthopedics
M. S. Meiss, K. M. Villagran-Andrade, P. C. Calder, J. G. Fernandez-Bolanos, C. Alarcon-de-la-Lastra, M. Sanchez-Hidalgo, F. J. Blanco, R. O. Oreffo, M. C. de Andres
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.
