Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Article
Nutrition & Dietetics
Xirui Wang, Xianting Jiao, Ying Tian, Jun Zhang, Yue Zhang, Juan Li, Fan Yang, Mingqing Xu, Xiaodan Yu
Summary: Maternal vitamin D concentrations in each trimester are positively associated with neonatal vitamin D status in cord blood, with the strongest correlation found in the late stage of pregnancy. This suggests that attention to vitamin D nutrition during pregnancy can help prevent vitamin D deficiency in newborns.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Oleg Tsuprykov, Saban Elitok, Claudia Buse, Chang Chu, Bernhard Karl Kraemer, Berthold Hocher
Summary: This study compared the correlation of different vitamin D compounds in pregnant women, finding that total 1,25(OH)(2)D showed the best correlation with various health markers. Free 25(OH)D and bioavailable 25(OH)D are more precise indicators of vitamin D status than total 25(OH)D.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Sigrun S. Skuladottir, Alfons Ramel, Hrafnhildur Eymundsdottir, Ingibjorg Hjaltadottir, Lenore J. Launer, Mary-Frances Cotch, Kristin Siggeirsdottir, Vilmundur Gudnason, Gunnar Sigurdsson, Laufey Steingrimsdottir, Thorhallur Halldorsson
Summary: Observational studies have consistently shown a higher risk of fractures in individuals with low serum 25-hydroxyvitamin D levels. This study aimed to examine the extent to which baseline measures of bone mineral density and physical function explain incident hip fractures in older adults with different serum 25(OH)D levels. The results indicated that deficient serum 25(OH)D status was associated with a higher risk of hip fractures, with this association being partially explained by poorer bone mineral density and physical function in males.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Anita Vergatti, Veronica Abate, Aquilino Flavio Zarrella, Fiore Manganelli, Stefano Tozza, Rosa Iodice, Gianpaolo De Filippo, Lanfranco D'Elia, Pasquale Strazzullo, Domenico Rendina
Summary: This meta-analysis found a significant association between 25(OH)D levels <= 8.5 ng/mL at the first stroke and an increased risk of recurrent stroke.
Article
Endocrinology & Metabolism
Yejin Kim, Yoosoo Chang, Seungho Ryu, In Young Cho, Min-Jung Kwon, Won Sohn, Mi Kyung Kim, Sarah H. Wild, Christopher D. Byrne
Summary: This retrospective cohort study found that maintaining adequate serum 25(OH)D concentrations may be beneficial for both the prevention and resolution of NAFLD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Laszlo Horvath, Sara Mirani, Michael Magdy Fahmy Girgis, Szilvia Racz, Ildiko Bacskay, Harjit Pal Bhattoa, Bela E. Toth
Summary: This study aimed to examine the vitD status of patients, explore the relationship between vitD deficiency and certain diseases, assess seasonality and trends, and reveal the indirect impact of the COVID-19 pandemic on vitD(3) supplementation at the population level. The results showed that 20% of all patients had hypovitaminosis D and males had higher odds for hypovitaminosis or vitD deficiency. VitD consumption exhibited seasonality, with higher consumption in autumn and winter. The findings highlight the importance of vitD(3) supplementation for at-risk groups and health education promoting vitamin D-3 supplementation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Tae-Eun Kim, Su Kang Kim, Min Kyung Shin, Ki-Heon Jeong, Mu-Hyoung Lee
Summary: The study investigated the serum vitamin D levels in vitiligo patients and compared the association of VDR gene polymorphisms in vitiligo patients and healthy controls. The results showed that there were no significant differences in serum vitamin D levels between vitiligo patients and the Korean population, as well as in the genotypic distributions of VDR gene between vitiligo patients and healthy controls.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Cedric Annweiler, Dimitrios Skoutas, Dimosthenis Evangelidis, Dimitrios Kiortsis
Summary: This study evaluated the impact of VDR gene polymorphisms and 25(OH)D levels on neonatal birth anthropometry, finding that maternal TAQI VDR gene polymorphism significantly affected birth outcomes when maternal 25(OH) concentrations were <50 nmol/L. Additionally, the study revealed that neonatal TAQI polymorphism had an effect when neonatal 25(OH)D levels were <25 nmol/L.
Article
Medical Laboratory Technology
Fanjun Meng, Ping Chen, Xiaolong Guo, Xiaoru Li, Yuexuan Wu, Wenen Liu, Feng Jiang, Huan Liu, Lixin Wang
Summary: This study found that serum levels of P2X7 were significantly increased in severe MPP patients, while serum levels of vitamin A, 25(OH)D, IgA, and IgG were significantly decreased.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Nutrition & Dietetics
Thu T. M. Pham, Ya-Li Huang, Jane C. -J. Chao, Jung-Su Chang, Yi-Chun Chen, Fan-Fen Wang, Chyi-Huey Bai
Summary: The study found no significant association between 25(OH)D concentration and GDM risk, but individuals with vitamin D deficiency had a higher risk of developing GDM. Additionally, there was a nonlinear relationship between 25(OH)D and GDM risk.
Article
Nutrition & Dietetics
Siew Siew Lee, King Hwa Ling, Maiza Tusimin, Raman Subramaniam, Kartini Farah Rahim, Su Peng Loh
Summary: This study examines the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. The results suggest that maternal vitamin D deficiency is inversely associated with birth weight, head circumference, and crown-heel length, while neonatal SNPs are significantly associated with birth weight and head circumference. A potential interaction between maternal SNP and vitamin D deficiency on head circumference is also observed.
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Vid Vicic, Andreja Kukec, Sasa Kugler, Ksenija Gersak, Josko Osredkar, Ruza Pandel Mikus
Summary: The objective of this study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. The study found that vitamin D insufficiency and deficiency were common among both premenopausal and postmenopausal women, with vitamin D supplementation and sun exposure being important predictors of vitamin D status. Interestingly, the vitamin D status in Slovenian postmenopausal women was better than in premenopausal women, which differs from similar studies.
Article
Pediatrics
Santtu Heinonen, Otto Helve, Sture Andersson, Cecilia Janer, Liina Suvari, Anu Kaskinen
Summary: Both term and preterm newborns exhibit lower expression levels of SARS-CoV-2 entry receptors in the nasal epithelium compared with adults. The low nasal expression of these receptors in newborns may contribute to the low attack rates and mild disease observed in this population.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Nutrition & Dietetics
Elisa M. Holmlund-Suila, Helena H. Hauta-alus, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M. Valkama, Sture Andersson, Outi Makitie
Summary: Iron deficiency is common in healthy infants and toddlers in Northern Europe. The prevalence of iron deficiency and iron deficiency anemia is higher in boys than in girls among infants. Iron intake remains below the recommended level, and food consumption and iron intake are associated with iron status.
CLINICAL NUTRITION
(2022)
Article
Psychology, Developmental
Sara Sammallahti, Elisa Holmlund-Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Helena Hauta-Alus, Marius Lahti-Pulkkinen, Hanan El Marroun, Henning Tiemeier, Outi Makitie, Sture Andersson, Katri Raikkonen, Kati Heinonen
Summary: Higher maternal vitamin D concentration during pregnancy is associated with better child mental health, particularly in relation to negative affectivity, a trait indicating increased risk of psychopathology. The study found that higher maternal early/mid-pregnancy vitamin D levels were associated with lower negative affectivity in infants, while cord blood vitamin D levels showed less clear associations. These findings suggest that maternal vitamin D status during early- and mid-pregnancy may play a role in the behavioral development of offspring.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Nursing
Arja Rantala, Anna-Leena Vuorinen, Jonna Koivisto, Heidi Simila, Otto Helve, Pekka Lahdenne, Minna Pikkarainen, Kadri Haljas, Tarja Polkki
Summary: This study protocol outlines a randomized controlled trial to evaluate the effectiveness of a gamified mobile health intervention for children in whole day surgery care. Participants will be randomly assigned to intervention and control groups, with a focus on children's pre-operative anxiety and other outcomes.
Article
Pediatrics
Elina Warnhjelm, Mitja Laaperi, Mikael Kuitunen, Otto Helve, Laura Puhakka, Heini Harve-Rytsala, Heli Salmi
Summary: This study aimed to investigate the immediate health effects of COVID-19 pandemic restrictions on children by examining pediatric emergency room visits. The results showed a significant decrease in ER visits during the pandemic period, but the severity of illnesses in children seen at the ER did not increase.
Article
Endocrinology & Metabolism
Helena H. Hauta-alus, Elisa M. Holmlund-Suila, Saara M. Valkama, Maria Enlund-Cerullo, Jenni Rosendahl, Ryan F. Coghlan, Sture Andersson, Outi Makitie
Summary: This study examines the relationship between Collagen X biomarker (CXM) and linear growth rate and bone development, as well as the modifying effects of vitamin D supplementation. The findings suggest that CXM is related to linear growth velocity during the second year of life but not to bone development. Furthermore, higher CXM levels in infants receiving higher vitamin D supplementation are associated with an accelerated growth rate in length.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Milla Mukka, Samuli Pesala, Aapo Juutinen, Mikko J. Virtanen, Pekka Mustonen, Minna Kaila, Otto Helve
Summary: Health care professionals in Finland rely on online databases for reliable medical information. This study compared searches for children's oseltamivir and influenza diagnoses in primary and specialized care to determine their potential usefulness in detecting influenza outbreaks. The results showed that searches for oseltamivir correlated with influenza diagnoses, suggesting that these database searches can supplement disease surveillance efforts.
Article
Public, Environmental & Occupational Health
Aapo Hiilamo, Tiina Ristikari, Otto Helve, Minna Kaila, Harri Jalonen, Petri Virtanen
Summary: This study investigated the extent to which Finnish political candidates consider children and their wellbeing in their election promises. The results show that an increasing number of candidates mention children in their election promises, but concrete proposals to improve the wellbeing and health of children are rare. The study suggests that effective policy solutions to improve children's health should be discussed in election debates.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Juho Kuula, Jesper Lundbom, Antti Hakkarainen, Petteri Hovi, Helena Hauta-alus, Nina Kaseva, Samuel Sandboge, Johan Bjorkqvist, Johan Eriksson, Kirsi H. Pietilainen, Nina Lundbom, Eero Kajantie
Summary: Adipose tissue volumes and hepatic triglyceride content were similar between adults born preterm at very low birth weight and their term siblings. Previously reported differences could be partly explained by shared genetic or environmental characteristics between siblings. The preterm VLBW group displayed lower unsaturation in subcutaneous abdominal adipose tissue, suggesting differences in metabolic activity and energy storage.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Akseli Talvasto, Minna Ilmakunnas, Peter Raivio, Hanna Vlasov, Seppo Hiippala, Raili Suojaranta, Erika Wilkman, Liisa Petaja, Otto Helve, Tatu Juvonen, Eero Pesonen
Summary: In this study, it was found that perioperative administration of 4% albumin, compared to Ringer's acetate, resulted in increased postoperative bleeding, higher use of blood cells and platelets, and increased probability of resternotomy.
ANNALS OF THORACIC SURGERY
(2023)
Article
Endocrinology & Metabolism
Freja Pontan, Helena Hauta-alus, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Sture Andersson, Outi Makitie, Elisa Holmlund-Suila
Summary: This study investigated the concentrations of alkaline phosphatase (ALP) and the prevalence of hyperphosphatasemia in healthy children, and their association with vitamin D, growth, infections, and bone parameters. It was found that boys had higher ALP levels than girls, and hyperphosphatasemia was more common at 12 months. Hyperphosphatasemia was associated with body size, growth rate, and bone mineralization, but not with infections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Genetics & Heredity
Maria Enlund-Cerullo, Elisa Holmlund-Suila, Saara Valkama, Helena Hauta-alus, Jenni Rosendahl, Sture Andersson, Minna Pekkinen, Outi Makitie
Summary: This study finds that genetic variation in FGF23 can modify cFGF23, phosphate, and pQCT-derived bone strength parameters in children aged 12 to 24 months. These findings promote a better understanding of the regulation of FGF23 and its role in bone metabolism during early childhood.
FRONTIERS IN GENETICS
(2023)
Review
Public, Environmental & Occupational Health
Antoni Soriano-Arandes, Ana Brett, Danilo Buonsenso, Louise Emilsson, Isabel de la Fuente Garcia, Despoina Gkentzi, Otto Helve, Kasper P. Kepp, Maria Mossberg, Taulant Muka, Alasdair Munro, Cihan Papan, Aida Perramon-Malavez, Frederik Schaltz-Buchholzer, Pierre R. Smeesters, Petra Zimmermann
Summary: This review analyzes the differences in epidemiology, policies, mitigation trade-offs, and outcomes between children and adults during the SARS-CoV-2 pandemic. It discusses the amount of mitigation children should bear and the uncertainties surrounding their role in transmission.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Mika Pihlajamaki, Sara Wickstrom, Kaija Puranen, Otto Helve, Aleksi Yrttiaho, Lotta Siira
Summary: This article shares the experience of implementing and running the Finnish exposure notification application (ENA) during the COVID-19 pandemic. The ENA prioritized user privacy and data security and achieved a 40% uptake in the population. However, the app needed adaptation and updating as the pandemic evolved and needs changed.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)