Article
Engineering, Chemical
Fuxin Zheng, Yunkun Wang
Summary: This study presents a method for fabricating selective polyelectrolyte multilayer membranes, which can effectively remove antibiotics and extracellular resistance genes (eARGs) from wastewater. The membranes demonstrated superior antibiotics retention and excellent removal of eARGs, providing a promising solution for remediation of antimicrobial resistance in wastewater.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Klemen Bohinc, Lora Kukic, Roman Stukelj, Anamarija Zore, Anze Abram, Tin Klacic, Davor Kovacevic
Summary: The application of catheters to the urinary tract is associated with nosocomial infections, which are one of the most common types of infections in hospitals and healthcare facilities. Coating catheter surfaces with polyelectrolyte multilayers has been shown to reduce bacterial adhesion and biofilm formation, with PSS-terminated multilayers exhibiting the lowest bacterial adhesion. The surface charge plays a crucial role in bacterial adhesion on both uncoated and coated PVC catheter surfaces, while roughness and hydrophobicity show similar properties.
Article
Polymer Science
Biswa P. Das, Marina Tsianou
Summary: Multilayer thin film assembly by the layer-by-layer (LbL) technique is an inexpensive and versatile route for the synthesis of functional nanomaterials. This study achieves exponential growth in clay-containing polyelectrolyte films with high clay loading and tailored properties by incorporating a weak polyelectrolyte and a clay with high charge density and small particle size. The findings include novel pathways to manipulate film characteristics. The presented strategy can lead to novel approaches to fabricate tailor-made nanomaterials for distinct applications.
Article
Engineering, Multidisciplinary
Sunghwan Hong, Seong Soo Yoo, Gwan Hyun Choi, Jun Hyuk Lee, Yong-Woo Choi, Minjun Kim, Eungchul Kim, S. Joon Kwon, Da Jeong Kim, Juhyun Park, Pil J. Yoo
Summary: A method for depositing barrier layers inside microchannels using surface charge-regulated layer-by-layer assembly of polyelectrolyte multilayers (PEM) is presented in this study to effectively resist the penetration of organic solvents, benefiting microfluidic systems and lab-on-a-chip devices. Through the use of highly negatively charged surface and size-narrowing effect in internal pores, excellent barrier performance against highly penetrating organic solvents was achieved.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Polymer Science
Nadia Asta, Michael S. Reid, Torbjorn Pettersson, Lars Wagberg
Summary: This study introduces a method to investigate molecular interactions between fibers by using precisely characterized model materials. The findings reveal a delicate balance in fiber-fiber joint formation and the potential for inducing built-in stresses in the interphase. This research lays the groundwork for creating high-performance biobased materials with tailored fiber-fiber interactions.
Article
Chemistry, Analytical
Daniel F. Kienle, Daniel K. Schwartz
Summary: In this study, the diffusion of small charged molecules in anisotropic polyelectrolyte multilayers was tracked in three dimensions using single-molecule fluorescence localization and Forster resonance energy transfer. The results showed a significantly slower diffusion in the surface-normal direction compared to lateral diffusion, which was hypothesized to be related to the periodic distribution of charge in the multilayer.
ANALYTICA CHIMICA ACTA
(2021)
Article
Electrochemistry
Karolina Sipa, Konrad Rudnicki, Neus Vila, Gregoire Herzog, Slawomira Skrzypek, Lukasz Poltorak, Alain Walcarius
Summary: This study focuses on the development of smart materials through simple modification techniques, utilizing layer-by-layer assembly over an electrode to create a platform with alternating amplification and sieving electrochemical properties. The designed platforms were tested with redox probes and applied to the electroanalytical screening of ascorbic acid and dopamine.
ELECTROCHEMISTRY COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Bhartendu Satywali, Volodymyr P. Kravchuk, Liqing Pan, M. Raju, Shikun He, Fusheng Ma, A. P. Petrovic, Markus Garst, Christos Panagopoulos
Summary: Non-collinear magnets exhibit a rich array of dynamic properties at microwave frequencies, hosting nanometre-scale topological textures known as skyrmions. The magnetic resonance study of an [Ir/Fe/Co/Pt] multilayer hosting Neel skyrmions at room temperature reveals distinct resonances with frequencies between 6-12 GHz, showing sensitivity to out-of-plane dipolar coupling. The gyration of stable isolated skyrmions reported in this study encourages the development of new material platforms and applications based on skyrmion resonances, with potential for tuning resonance spectra and expanding functionality over a broadband frequency range.
NATURE COMMUNICATIONS
(2021)
Article
Polymer Science
Carolin Naas, Ulrich Scheler, Uwe Lappan
Summary: The growth and mobility of polyelectrolyte multilayers can be influenced by adjusting the pH value during preparation. Changes in pH lead to non-linear growth behavior and affect the formation and properties of the multilayers.
Article
Polymer Science
Kamila Sofinska, Jakub Barbasz, Michal Ciesla, Agata Wawrzkiewicz-Jalowiecka, Ewa Gudowska-Nowak
Summary: Dynamic force spectroscopy is used to study the structure and dynamics of interacting molecules or surfaces at a molecular level by applying mechanical forces in a controlled manner. Experimental data on the rupture force spectra of a poly(ethyleneimine) model system on a silica surface show discrepancies with models, and the results are analyzed statistically.
Article
Multidisciplinary Sciences
Maria Dabkowska, Iga Stukan, Boguslaw Kowalski, Wiktoria Donerowicz, Monika Wasilewska, Alicja Szatanik, Malgorzata Stanczyk-Dunaj, Aneta Michna
Summary: Biomaterial science has made significant contributions to the development of nanoscale materials for delivering biologically active compounds and enhancing protein stability. In this study, a polyelectrolyte multilayer (PEM) was formed by sequentially adsorbing positively charged polydiallyldimethylammonium chloride (PDADMAC) and negatively charged heparin sodium salt (HP) on a solid substrate. The PEM was used as a platform for adsorbing brain-derived growth factor (BDNF) and showed high adsorption capacity under physiological conditions. In vitro experiments demonstrated that the PEMs with adsorbed BDNF exhibited antioxidant properties and enhanced cellular 3D structure formation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Haseeb Iqbal, Faratiana Jeanne Rosine Revana, Emeline Pradel, Varvara Gribova, Kamel Mamchaoui, Catherine Coirault, Florent Meyer, Fouzia Boulmedais
Summary: The engineering of skeletal muscle tissue is a promising approach for the treatment of muscle injuries and diseases. In this study, a hydrogen-bonded nanofilm was developed using a brushing method to promote muscle tissue development. The nanofilm successfully guided the alignment and differentiation of muscle cells, resulting in the formation of aligned myofibers.
Article
Engineering, Biomedical
Catharina Husteden, Yazmin A. Brito Barrera, Sophia Tegtmeyer, Joao Borges, Julia Giselbrecht, Matthias Menzel, Andreas Langner, Joao F. Mano, Christian E. H. Schmelzer, Christian Woelk, Thomas Groth
Summary: This article presents a gene-activated surface coating strategy for designing smart biomaterials for bone tissue engineering. The thin-film coating is made of polyelectrolyte multilayers composed of collagen I and chondroitin sulfate, and further functionalized with DNA/lipid-nanoparticles. The successful formation of the thin-film, fibrillar structuring of collagen, and homogeneous embedding of lipoplexes is demonstrated. Culturing mesenchymal stem cells on the functionalized multilayer shows excellent attachment, growth, and uptake of cargo like fluorescence-labelled DNA from lipoplexes. Furthermore, the functionalization of the multilayer induces osteogenic differentiation of mesenchymal stem cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Chemical
Moritz A. Junker, Esra te Brinke, Clara M. Vall Compte, Rob G. H. Lammertink, Joris de Grooth, Wiebe M. de Vos
Summary: Polyelectrolyte multilayers (PEMs) show promise as selective layers in nanofiltration (NF) due to their simplicity, controlled layer thickness, and versatility. Combining two different PEMs in an asymmetric structure allows further optimization. This study combines experimental filtration and theoretical models to describe the effective structure of an asymmetric PEM made of PAH/PSS and PAH/PAA. The obtained membrane properties suggest a distinct layer structure, and there is a fundamental difference in the retention of salt and polyethylene glycol molecules, attributed to different exclusion mechanisms.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Review
Polymer Science
Suman Pahal, Rakshith Boranna, Gurusiddappa R. Prashanth, Manoj M. Varma
Summary: This article discusses the matrix properties and molecular diffusion in polyelectrolyte multilayer thin films (PEM), highlighting different strategies to promote or suppress diffusivity within the PEM. It uncovers guiding principles for understanding molecular transport on the surface and across the bulk of the PEM matrix, which can contribute to the design of desirable PEM assembly structures. Understanding molecular diffusivity at nano and micro scales within PEM stacks will aid in designing superior host materials for biomedical engineering applications.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Polymer Science
Katiuscia Vieira Jardim, Abraham F. Palomec-Garfias, Marcus Vinicius Araujo, Cesar Marquez-Beltran, Andris Figueiroa Bakuzis, Sergio Enrique Moya, Alexandre Luis Parize, Marcelo Henrique Sousa
Summary: Curcumin, a natural drug with promising potential in cancer therapy, has limited applicability due to its low solubility, short half-life, and low bioavailability. In this study, curcumin was encapsulated in stimuli-responsive magneto-polymeric nanoplatforms to improve its bioavailability and delivery efficiency. The results showed that magnetic hyperthermia can provide a means for the controlled release of curcumin, leading to enhanced therapeutic action.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
Hernan Martinelli, Elisamaria Tasca, Patrizia Andreozzi, Sara Libertone, Hernan Ritacco, Mauro Giustini, Sergio E. Moya
Summary: The study explores the polarity at the single polyelectrolyte layer level inside PEMs using DX, and finds that different polar environments may be present in a PEM due to variations in charge compensation between layers.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Rayane Ganassin, Victor Carlos Mello da Silva, Victor Hugo Sousa Araujo, Giulia Rosa Tavares, Patricia Bento da Silva, Paolin Rocio Caceres-Velez, Joaquin E. Martinez Porcel, Mosar Correa Rodrigues, Patrizia Andreozzi, Richard Perosa Fernandes, Bruno Fonseca-Santos, Sergio Moya, Ricardo Bentes Azevedo, Marlus Chorilli, Luis Alexandre Muehlmann
Summary: This study successfully developed a new curcumin carrier called SLN-Cs consisting of murumuru butter nanoparticles, and demonstrated that SLN-Cs were more toxic to colon adenocarcinoma cells, indicating that SLN-Cs are suitable carriers of curcumin in aqueous media.
Article
Chemistry, Inorganic & Nuclear
Elisa Bindini, Tanja Luedtke, Dorleta Otaegui, Marco Moeller, Ryma Haddad, Cedric Boissiere, Sergio E. Moya
Summary: Surface engineering of metal-organic frameworks with a mesoporous silica coating can enhance mechanical properties and allow for decoration with organic or biological molecules. However, destabilization of the core during deposition of the silica shell may occur, but can be controlled by adjusting silicate concentration to preserve the MOF integrity. The resulting core-shell nanoparticles demonstrate a compact structure with no gap between the MOF core and the silica shell, showcasing potential for designing new hierarchical materials.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Gustavo M. Segovia, Juan A. Allegretto, Jimena S. Tuninetti, Lucia B. Pizarro, Agustin S. Picco, Marcelo Ceolin, Tanja Ursula Ludtke, Elisa Bindini, Desire Di Silvio, Sergio E. Moya, Omar Azzaroni, Matias Rafti
Summary: This study focuses on the thermodynamic and kinetic aspects of ZIF-8 MOF synthesis using methanolic solutions of precursors and 3-mercaptopropionic acid (MPA) as a chemical modifying agent. The results show that MPA plays a crucial role in controlling the surface chemistry, shape, and size of the synthesized nanounits, indicating its potential for modifying MOF materials. Additionally, characterization techniques such as SAXS/WAXS, electron microscopy, XPS, nitrogen adsorption, DLS, and ITC were utilized to study the influence of MPA on the nucleation and growth processes, as well as the enthalpy associated with the coordination between Zn2+ and MPA.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Samuel E. Hoff, Desire Di Silvio, Ronald F. Ziolo, Sergio E. Moya, Hendrik Heinz
Summary: Functionalization of nanoparticles with specific ligands can control specific diagnostic and therapeutic responses. This study uses molecular dynamics simulations to investigate self-assembled monolayers of multisegment ligands on gold nanoparticles, showing that they can mimic mixed hydrophobic and hydrophilic ligand coatings, with control over patterns, hydrophilicity, and specific recognition properties.
Article
Chemistry, Physical
Eva Clemente, Marta Martinez-Moro, Duong N. Trinh, Mahmoud G. Soliman, Daniel I. R. Spencer, Richard A. Gardner, Maximilianos Kotsias, Ana Sanchez Iglesias, Sergio Moya, Marco P. Monopoli
Summary: This study characterized the biomolecular corona of gold nanoparticles in blood plasma and revealed that the protein composition of the corona varies with different plasma concentrations. The study also demonstrated that the glycans in the corona can interact with lectins with known affinity, suggesting their potential role in modulating nanoparticle biological processes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
M. Jazmin Penelas, Gustavo F. Arenas, Fernando Trabadelo, Galo J. A. A. Soler-Illia, Sergio E. Moya, Paula C. Angelome, Cristina E. Hoppe
Summary: In this study, monodisperse silica-coated gold nanoparticles were synthesized to obtain aqueous colloidal dispersions with an optimal balance between colloidal stability and photothermal activity. The presence of a silica shell not only enhanced the photothermal effect but also controlled the optical properties of the colloidal dispersions, making them highly valuable for biomedical therapies, sensing applications, and other technological applications.
Article
Chemistry, Multidisciplinary
Rohini Thevi Guntnur, Nicolas Muzzio, Amanda Gomez, Sean Macias, Arturo Galindo, Arturo Ponce, Gabriela Romero
Summary: This study describes a wireless chemomagnetic neuromodulation platform that uses nanoscale heating to control primary striatal neurons. By inducing a thermodynamic phase transition, dopamine release is enhanced, resulting in increased neural activity. This research represents a significant advancement in the chemomagnetic control of neural activity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Paolo Canepa, Danijela Gregurec, Nara Liessi, Silvia Maria Cristina Rotondi, Sergio Enrique Moya, Enrico Millo, Maurizio Canepa, Ornella Cavalleri
Summary: Porous transition metal oxides were functionalized with amino acids to improve antibacterial properties. Two-step molecular deposition was used and investigated with AFM and XPS. The formation of monolayers was confirmed on flat titanium oxide thin films, and successful coupling with Fmoc-Leucine was observed through XPS analysis.
Article
Multidisciplinary Sciences
Patrick M. Perrigue, Agata Henschke, Bartosz F. Grzeskowiak, Lucja Przysiecka, Kaja Jaskot, Angelika Mielcarek, Emerson Coy, Sergio E. Moya
Summary: Understanding the interaction between nanoparticles and cells is crucial for designing more effective nanomedicines. This study investigates the biological fate of silica nanoparticles in senescent cells, which do not divide, using various methods including microscopy and flow cytometry. The results show that the nanoparticles readily enter the senescent cells and accumulate in the cytoplasm for a long time. This study lays the foundation for the development of NP-based tools for detecting and targeting senescent cells for therapeutic purposes.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Naixin Kang, Ruofan Shen, Baojun Li, Fangyu Fu, Bruno Espuche, Sergio Moya, Lionel Salmon, Jean-Luc Pozzo, Didier Astruc
Summary: The synthesized AuPd@ZIF-8-alloyed nanoparticles serve as an excellent nanocatalyst for the methanolysis reaction of aminoborane under visible light irradiation, producing H-2 at a high rate. The visible-light-induced acceleration is attributed to the Au plasmonic excitation provoking hot electron transfer from Au to Pd-substrate ensemble.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Nanoscience & Nanotechnology
Cristian Salvador, Patrizia Andreozzi, Gabriela Romero, Iraida Loinaz, Damien Dupin, Sergio E. Moya
Summary: Small interference RNA (siRNA) is a gene modulation tool that can silence genes associated with genetic disorders. However, the instability of siRNA in the blood and its difficulty in reaching the cytosol limit its therapeutic potential. Polyamine-based nanoparticles, particularly polyallylamine hydrochloride (PAH), show promise in gene delivery. In this study, PAH was chemically modified with oleic acid to improve cell viability and siRNA transfection efficiency. The PAH-oleic acid substitutes were effective in silencing the CD47 protein, making them a potential candidate for immunotherapy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Cell & Tissue Engineering
Amanda Gomez, Nicolas Muzzio, Ania Dudek, Athena Santi, Carolina Redondo, Raquel Zurbano, Rafael Morales, Gabriela Romero
Summary: This paper describes a noninvasive neurostimulation platform that utilizes magnetic nanotechnologies for cell-type-specific manipulation of neural signaling.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Cristian Salvador, Patrizia Andreozzi, Gabriela Romero, Iraida Loinaz, Damien Dupin, Sergio E. Moya
Summary: Small interference RNA (siRNA) is a gene modulation tool that can silence genes related to genetic disorders. Polyamine-based nanoparticles, particularly polyallylamine hydrochloride (PAH) covalently functionalized with oleic acid, show promise in gene delivery and siRNA transfection. The substitution of PAH with oleic acid improves cell viability and siRNA transfection efficiency, particularly in silencing the CD47 protein for potential use in immunotherapy.
ACS APPLIED BIO MATERIALS
(2023)
