Review
Cell Biology
Daniele Santi, Giorgia Spaggiari, Walter Vena, Alessandro Pizzocaro, Mario Maggi, Vincenzo Rochira, Giovanni Corona
Summary: The study aims to estimate the prevalence of pituitary-testis axis abnormality in HIV-infected patients compared to uninfected subjects, and evaluate the effect of androgen administration on body composition in HIV-infected men. The review confirms a high prevalence of testosterone deficiency in HIV-infected men and shows that androgen supplementation can improve body composition.
Review
Nutrition & Dietetics
Damoon Ashtary-Larky, Reza Bagheri, Grant M. Tinsley, Omid Asbaghi, Sara Salehpour, Sara Kashkooli, Wesam Kooti, Alexei Wong
Summary: This systematic review and meta-analysis found no significant effects of betaine supplementation on body composition indices such as body weight, BMI, body fat percentage, fat mass, and fat-free mass. No changes in dietary intakes were observed following betaine supplementation compared with control, except for a potential slight increase in protein intake.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Endocrinology & Metabolism
G. Corona, W. Vena, A. Pizzocaro, V. A. Giagulli, D. Francomano, G. Rastrelli, G. Mazziotti, A. Aversa, A. M. Isidori, R. Pivonello, L. Vignozzi, E. Mannucci, M. Maggi, A. Ferlin
Summary: Testosterone replacement therapy (TRT) can inhibit bone resorption and increase bone mass, especially at the lumbar spine level. The effects are more prominent with longer duration of treatment and higher prevalence of diabetes in patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Review
Endocrinology & Metabolism
Saeede Saadati, Kaveh Naseri, Omid Asbaghi, Mohsen Yousefi, Elnaz Golalipour, Barbora de Courten
Summary: Studies have shown that probiotics and synbiotics have beneficial effects on body weight and composition in adults, making them useful as add-ons to weight loss products and medications.
Article
Biochemistry & Molecular Biology
Dhruba Tara Maharjan, Ali Alamdar Shah Syed, Guan Ning Lin, Weihai Ying
Summary: The study found a significant association between female depression and serum testosterone levels, particularly in the premenopausal group. However, the analysis results did not support a causal relationship between testosterone and depression, suggesting that the differences in serum testosterone levels between healthy and depressed women are likely more influenced by the disease itself.
Review
Food Science & Technology
Navid Naghsh, Amir Hossein Moridpour, Zeynab Kavyani, Vali Musazadeh, Jaber Jafarzadeh, Ehsan Safaei, Cain C. T. Clark, Amir Hossein Faghfouri
Summary: Many studies have examined the effects of Nigella Sativa supplementation on anthropometric indices, but the results have been inconsistent. This systematic review and meta-analysis found that N. sativa supplementation significantly reduced body weight and BMI in adults, but had no significant effect on waist circumference, hip circumference, and waist-to-hip ratio. Based on these findings, N. sativa supplementation may be a recommended adjunctive intervention in obesity management.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Andrology
Daniele Santi, Angelo Cignarelli, Matteo Baldi, Andrea Sansone, Giorgia Spaggiari, Manuela Simoni, Giovanni Corona
Summary: This meta-analysis found that alcohol consumption is associated with a significant reduction in total testosterone, free testosterone, and sex hormone binding globulin levels in healthy men. It also found an increase in estradiol levels. However, these effects were only observed in men with chronic alcohol consumption and not in those with recognized alcohol use disorder or after acute alcohol intake.
Review
Nutrition & Dietetics
Damoon Ashtary-Larky, Reza Bagheri, Matin Ghanavati, Omid Asbaghi, Alexei Wong, Jeffrey R. Stout, Katsuhiko Suzuki
Summary: This systematic review and meta-analysis found that beta-alanine supplementation has no significant effects on body composition indices. The certainty of evidence ranged from low to moderate. Future studies should investigate the combination of beta-alanine supplementation with a hypocaloric diet and exercise programs on body composition changes.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yoshihiro Ikehata, Tsuyoshi Hachiya, Takuro Kobayashi, Hisamitsu Ide, Shigeo Horie
Summary: This study investigates the causal association between body composition and testosterone levels using Mendelian randomization. The results suggest that reducing fat mass may increase testosterone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Kristine Ma, Shu Qin Wei, Wei Guang Bi, Hope A. Weiler, Shi Wu Wen
Summary: Vitamin D supplementation during pregnancy and infancy may lead to increased triceps skinfold thickness in neonates, increased length for age z-score in infants at 1 year, and decreased BMI and BMI z-score in offspring at 3-6 years.
Review
Nutrition & Dietetics
Vali Musazadeh, Meysam Zarezadeh, Faezeh Ghalichi, Fateme Hamedi Kalajahi, Zohreh Ghoreishi
Summary: Vitamin D supplementation significantly reduces body mass index (BMI) and waist circumference (WC), but has no significant effect on body weight and fat mass.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Qiliang Pang, Aoyun Jia, Mohammad Khaldoun Al Masri, Hamed Kord Varkaneh, Ahmed Abu-Zaid, Xiang Gao
Summary: This study conducted a systematic review and meta-analysis of multiple randomized controlled trials, revealing that androstenedione supplementation can lower triglycerides and high-density lipoprotein cholesterol, and increase estradiol concentrations.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Nutrition & Dietetics
Rami Al-Jafar, Nisa Sri Wahyuni, Karim Belhaj, Mohammad Hamed Ersi, Zahra Boroghani, Amer Alreshidi, Zahra Alkhalaf, Paul Elliott, Konstantinos K. K. Tsilidis, Abbas Dehghan
Summary: This study investigated the effects of Ramadan intermittent fasting on anthropometry and body composition. The results showed reductions in weight, waist circumference, hip circumference, body mass index, waist-to-hip ratio, basal metabolic rate, fat percentage, etc., during the fasting period, but these parameters started to reverse after fasting. This phenomenon was also confirmed in other studies.
FRONTIERS IN NUTRITION
(2023)
Review
Environmental Sciences
Tatiana Duque-Cartagena, Eduardo Mundstock, Marcello Dala Dalla Bernardina, Alexandre Vontobel Padoin, Wilson Canon-Montanez, Rita Mattiello
Summary: The effect of environmental pollution on human health is significant, leading to higher mortality and morbidity rates. This study aimed to explore the impact of pollutants on various measures of body composition. The findings suggest that endocrine-disrupting chemicals, such as dioxins, furans, PCBs, and pesticides, are associated with changes in body composition, particularly waist circumference and the sum of four skinfolds.
ENVIRONMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Maryam Kazemi, Roger A. Pierson, Stephen A. Parry, Mojtaba Kaviani, Philip D. Chilibeck
Summary: Women with polycystic ovary syndrome (PCOS) do not show significant differences in muscle lean tissue mass compared to controls, but they do have an increase in this metric related to overweight/obesity, unrelated to hyperandrogenism or insulin resistance.
Article
Social Sciences, Interdisciplinary
Maria Grazia Vaccaro, Giulia Izzo, Alessia Sarica, Sandro La Vignera, Antonio Aversa
Summary: This study aims to analyze the different perceptions of sociosexual experiences among the southern population during the COVID-19 pandemic. Through cluster analysis, we identified eleven clusters and found intra- and inter-diagnostic heterogeneity in the sexual profile of participants. We also discovered significant gender differences, with women showing a greater propensity for positive sexual attitudes and desires compared to men.
SEXUALITY RESEARCH AND SOCIAL POLICY
(2023)
Article
Environmental Sciences
Costanza Calamai, Oumaima Ammar, Sara Marchiani, Selene Degl'Innocenti, Marisa Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi, Monica Muratori
Summary: In March 2020, the Italian government implemented a national lockdown, which resulted in a significant reduction in air pollutants and an improvement in sperm motility and DNA quality of male infertility patients after the lockdown period.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Environmental Sciences
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Summary: The neuroendocrine control of reproduction is regulated by the pulsatile release of GnRH by hypothalamic neurons. BaP, a pollutant, can disrupt endocrine function and affect gonadal function and gamete maturation. This study found that BaP alters the phenotype and function of GnRH neurons by interfering with KISS1R signaling and GnRH secretion, highlighting its importance in the central neuroendocrine control of reproduction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Andrology
Arcangelo Barbonetti, Giulia Rastrelli, Clotilde Sparano, Chiara Castellini, Linda Vignozzi, Mario Maggi, Giovanni Corona
Summary: A study found that male cannabis users are younger, have fewer comorbidities, and have better sexual performance compared to non-users. Cannabis use is associated with a more unstable relationship and a higher frequency of masturbation. Cannabis use may improve anthropometric and lipid profiles as well as penile arterial response in patients with sexual dysfunction.
Review
Andrology
Giovanni Corona, Walter Vena, Alessandro Pizzocaro, Linda Vignozzi, Alessandra Sforza, Mario Maggi
Summary: Type 2 diabetes mellitus and pre-diabetes are associated with reduced levels of circulating testosterone, but the role of testosterone replacement therapy in these patients is still uncertain.
Article
Andrology
Dimitri Yannas, Elena Zago, Elena Cavallini, Tommaso Todisco, Linda Vignozzi, Giovanni Corona, Mario Maggi, Giulia Rastrelli
Summary: This study found that the level of education is closely associated with erectile dysfunction and cardiovascular risk in men. Men with lower education level are more likely to have erectile dysfunction and metabolic syndrome, as well as a higher risk of cardiovascular events.
Article
Genetics & Heredity
Maria Carmela Zagari, Paola Chiarello, Stefano Iuliano, Lucia D'Antona, Valentina Rocca, Emma Colao, Nicola Perrotti, Francesca Greco, Rodolfo Iuliano, Antonio Aversa
Summary: Loss of function mutations in the PHEX gene can lead to X-linked dominant hypophosphatemia, the most common form of genetic rickets. This condition is characterized by renal phosphate wasting, increased fibroblast growth factor 23 (FGF-23), growth retardation, bone deformities, and musculoskeletal manifestations. Despite the discovery of numerous mutations in the PHEX gene, there are currently no clear genotype-phenotype correlations in patients with hypophosphatemic rickets (XLH).
Review
Urology & Nephrology
G. Corona, G. Rastrelli, N. Bianchi, C. Sparano, A. Sforza, L. Vignozzi, M. Maggi
Summary: The present paper aims to analyze and discuss the relationship between male sexual function and elevated prolactin (PRL) levels (HPRL) using clinical data and meta-analytic approach. 4.2% of patients seeking medical care for sexual dysfunction showed PRL levels above the normal range. HPRL was found to have a negative influence on male sexual desire. Treating HPRL can improve libido, but its effect on erection is limited. The role of HPRL in erectile dysfunction remains inconclusive. Overall, the paper provides important evidence on the relationship between PRL levels and male sexual function.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Ilaria Dicembrini, Giovanni Antonio Silverii, Alessandra Clerico, Riccardo Fornengo, Giovanni Gabutti, Valeria Sordi, Silvio Tafuri, Ottavia Peruzzi, Edoardo Mannucci
Summary: This study collected evidence on the risk of influenza complications in people with diabetes and the effectiveness of influenza vaccines in these individuals. The results showed that diabetes increases the risk of severe complications from influenza, and influenza vaccination has a significant protective effect for patients with diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Nutrition & Dietetics
Elisabetta Bigagli, Mario D'Ambrosio, Lorenzo Cinci, Camilla Fiorindi, Sara Agostiniani, Elisa Bruscoli, Anita Nannoni, Maura Lodovici, Stefano Scaringi, Francesco Giudici, Cristina Luceri
Summary: International guidelines recommend peri-operative immunonutrition (IN) support for colorectal surgery patients to reduce postoperative complications. This pilot study on Crohn's patients undergoing intestinal surgery found that IN patients had lower plasma levels of AGEs and higher mucosal TJP1 expression, suggesting that IN may improve intestinal mucosa barrier function through the regulation of AGEs/RAGE signaling. The study also found positive correlations between plasma and tissue levels of AGEs and AOPPs, as well as negative correlations between plasma AGEs and TJP1 expression, and between RAGE expression and TJP1 gene expression.
Article
Medicine, General & Internal
Andrea Crafa, Aldo Eugenio Calogero, Rossella Cannarella, Rosita Angela Condorelli, Antonio Aversa, Sandro La Vignera
Summary: Male infertility and prostate cancer are the most researched andrological diseases, followed by benign prostatic hyperplasia and erectile dysfunction, which are expected to increase in prevalence due to population aging. However, research on inflammation of the accessory sexual glands is relatively scarce.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Livia Basile, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Federica Barbagallo, Andrea Crafa, Antonio Aversa, Sandro La Vignera
Summary: Red wine is rich in nutrients and has been the focus of numerous scientific studies. It has been reported that moderate consumption of red wine, with its phenolic and antioxidant properties, can have positive effects on various diseases. Additionally, the ethanol content in red wine has shown various biological properties. However, little is known about the correlation between red wine consumption and male sexual function. This review aimed to evaluate the effects of moderate red wine consumption on erectile function and found potential benefits in patients with erectile dysfunction as well as positive influences on reproductive function through vasorelaxant and antioxidant mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Rossella Cannarella, Cristina M. B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This article provides an overview of the molecular mechanisms and usage of follicle-stimulating hormone (FSH) in the treatment of male infertility. It also evaluates the predictor factors of FSH administration response and the indications of the latest guidelines on the use of FSH in male infertility treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Medicine, General & Internal
Sara Marchiani, Selene Degl'Innocenti, Sara Dabizzi, Lara Tamburrino, Maria Grazia Fino, Giulia Traini, Costanza Calamai, Mario Maggi, Linda Vignozzi, Elisabetta Baldi, Francesco Lotti
Summary: Sperm cryopreservation is recommended for male fertility preservation in cancer patients or other medical conditions. The recovery rates of motility and viability vary depending on the medical condition. Our study showed that lower sperm quality led to lower recovery rates, and donor samples had the highest recovery rates. Cut-off values for motility recovery were established based on initial semen quality. Overall, our results emphasize the importance of considering intrinsic sperm characteristics in cryopreservation.
JOURNAL OF CLINICAL MEDICINE
(2023)
