期刊
EUROPEAN JOURNAL OF ENDOCRINOLOGY
卷 174, 期 1, 页码 69-75出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/EJE-15-0781
关键词
-
资金
- European Research Council [StG-282255]
- Swedish Medical Research Council
- Swedish Heart and Lung Foundation
- Medical Faculty of Lund University
- Malmo University Hospital
- Albert Pahlsson Research Foundation
- Crafoord Foundation
- Ernhold Lundstroms Research Foundation
- Region Skane
- Hulda and Conrad Mossfelt Foundation
- King Gustaf V and Queen Victoria Foundation
- Novo Nordisk Foundation
- Wallenberg Foundation
- Novo Nordisk Fonden [NNF13OC0005339, NNF14OC0009819] Funding Source: researchfish
Objective: Recently, imbalance in the vasopressin (AVP) system, measured as elevated levels of copeptin (the C-terminal part of the AVP pro-hormone) in plasma, was linked to the development of abdominal obesity and diabetes mellitus (DM). Here, we aim to investigate if the genetic variation of the human AVP receptor 1b gene (AVPR1B) is associated with measures of obesity and DM. Design: Malmo Diet and Cancer study (MDC) is a population-based prospective cohort examined 1991-1996. Methods: Four tag single nucleotide polymorphisms (SNPs: rs35810727, rs28373064, rs35439639, rs35608965) of AVPR1B were genotyped in the cardiovascular cohort (n=6103) of MDC (MDC-CC) and associated with measures of obesity and DM. Significant SNPs were replicated in another 24 344 MDC individuals (MDC replication cohort). Results: In MDC-CC, the major allele of rs35810727 was associated with elevated BMI (beta-coefficient +/- S.E.M.; 0.30 +/- 0.14, P=0.03) and waist (0.78 +/- 0.36, P=0.03) after age and gender adjustment. The association with BMI was replicated in the MDC replication cohort (0.21 +/- 0.07, P=0.003), whereas that with waist was not significant. In MDC-CC there was no association between the major allele of rs35810727 and DM, but in the complete MDC cohort (n=30 447) the major allele of rs35810727 was associated with DM (OR (95% CI); 1.10 (1.00-1.20), P=0.04). Conclusions: Genetic variance of AVPR1B contributes to overweight. Furthermore, our data indicate a link between AVPR1B variance and DM development. Our data point at a relationship between the disturbance of the pharmacologically modifiable AVP system and the body weight regulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据