期刊
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
卷 9, 期 2, 页码 126-132出版社
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
DOI: 10.4168/aair.2017.9.2.126
关键词
Bronchial asthma; exhaled breath condensate; periostin
资金
- National Science Centre [2011/02/A/N25/00341]
- Medical University of Lodz [503/1-137-01/503-01]
- Healthy Ageing Research Centre [REGPOT-2012-2013-1, 7FP]
- National Science Centre [2011/02/A/N25/00341]
- Medical University of Lodz [503/1-137-01/503-01]
- Healthy Ageing Research Centre [REGPOT-2012-2013-1, 7FP]
Purpose: Periostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) and chronic rhinosinusitis (CRS). In this study, we aimed to evaluate Periostin in exhaled breath condensate (EBC) and in serum of patients with various asthma phenotypes. Methods: The study included 40 asthmatic patients (22 with NERD) and '17 healthy controls. All the procedures (questionnaire, spirometry, FeNO, nasal swabs, EBC collecting, and blood sampling) were performed on the same day. Periostin concentrations were measured using an ELISA kit. Results: Periostin was detected in EBC from 37 of 40 asthmatics and in 16 from '17 of controls. The concentration of periostin in EBC did not differ between the study groups and was not associated with NERD or asthma severity. However, the EBC periostin was significantly higher in asthmatics with CRS as compared to those without (3.1 vs 2 ng/mL, P=0.046). Patients with positive bacterial culture from nasal swabs had higher EBC periostin concentrations than those without (3.2 vs 2.1 ng/mL; P=0.046). The mean serum periostin level was higher in asthmatics with a 1 -year history of exacerbation than in those without (3.2 vs 2.3 ng/mL, P=0.045). Asthmatics with skin manifestation of NSAIDs hypersensitivity had higher serum periostin levels as compared to those without (3.5 vs 2.3 ng/mL; P=0.03). Conclusions: EBC periostin levels seem to reflect intensity of upper airway disease in asthmatics, while serum levels, of periostin are associated With asthma activity (exacerbations or FeNO) or NERD subphenotypes.
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