Review
Pharmacology & Pharmacy
Betina M. R. Carvalho, Laranda C. Nascimento, Jessica C. Nascimento, Vitoria S. dos S. Goncalves, Patricia K. Ziegelmann, Debora S. Tavares, Adriana G. Guimaraes
Summary: This study aims to obtain scientific evidence on the use of Citrus to control dyslipidemia. The study found that Citrus products have positive effects on dyslipidemia, reducing total cholesterol, LDL, and triglycerides levels, while increasing HDL.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Seth S. Martin, Justin K. Niles, Harvey W. Kaufman, Zuhier Awan, Ola Elgaddar, Rihwa Choi, Sunhyun Ahn, Rajan Verma, Mahesh Nagarajan, Andrew Don-Wauchope, Maria Helane Costa Gurgel Castelo, Caio Kenji Hirose, David James, Derek Truman, Maja Todorovska, Ana Momirovska, Hedviga Pivovarnikova, Monika Rakociova, Pedro Louzao-Gudin, Janserey Batu, Nehmat El Banna, Hema Kapoor
Summary: This study evaluated the variation in lipid profiles across different countries to improve understanding of cardiovascular risk and interventions. The results showed wide variation in lipid levels worldwide, reflecting differences in genetics, testing methods, lifestyle habits, and treatments. Elevated atherogenic lipid levels are a common global problem, highlighting the importance of national policies and health system approaches to reduce cardiovascular disease risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Chemistry, Applied
Yazhong Ge, Huamai Qiu, Jianxian Zheng
Summary: The study found that polysaccharide extracted from Helvella leucopus can lower the levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol in hyperlipidemic mice. It also regulates liver function and blood lipid metabolism. This suggests that Helvella leucopus polysaccharide could be a new complementary alternative strategy for managing hyperlipidemia.
Article
Nutrition & Dietetics
Haksoo Lee, Eunguk Shin, Hyunkoo Kang, HyeSook Youn, BuHyun Youn
Summary: Soybean hydrolysate contains bioactive peptides that can reduce blood lipid concentrations by promoting trans-intestinal cholesterol excretion and inhibiting hepatic bile acid synthesis.
Article
Plant Sciences
Qi Zheng, Xiaojiaoyang Li, Nana Huang, Fanghong Li, Junde Ge, Daijie Wang, Rong Sun, Runping Liu
Summary: This study demonstrated that Saikosaponins (SSs) from traditional Chinese medicine have therapeutic effects on hyperlipidemia by reducing the levels of cholesterol and triglyceride, improving the imbalance of lipid metabolism, and reducing oxidative stress and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Seetha Anitha, Rosemary Botha, Joanna Kane-Potaka, D. Ian Givens, Ananthan Rajendran, Takuji W. Tsusaka, Raj Kumar Bhandari
Summary: The consumption of millets can reduce levels of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol, helping to manage hyperlipidemia and hypertension while increasing levels of high-density lipoprotein cholesterol, which is beneficial for preventing cardiovascular diseases.
FRONTIERS IN NUTRITION
(2021)
Review
Endocrinology & Metabolism
Fengcui Sun, Xiufen Yang, Chaoqun Ma, Shizhao Zhang, Lu Yu, Haifei Lu, Guoliang Yin, Pengpeng Liang, Yanan Feng, Fengxia Zhang
Summary: Hyperlipidemia, a disorder of lipid metabolism, requires the development of safer and more effective drugs. Diosgenin, derived from natural sources like fenugreek seeds, has shown potential for correcting lipid metabolism disorders.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Jian Lu, Xuyang Shang, Bingyi Yao, Dongyi Sun, Jie Liu, Yuanjin Zhang, He Wang, Jingru Shi, Huaqing Chen, Tieliu Shi, Mingyao Liu, Xin Wang
Summary: Cholesterol is a precursor for various endogenous molecules and its disruption can lead to liver and cardiovascular diseases. The function of CYP1A in cholesterol homeostasis has not been fully understood. This study aims to explore the role of CYP1A in regulating cholesterol homeostasis. The results show that CYP1A1/2 knockout rats exhibit cholesterol deposition in blood and liver, with increased levels of LDL cholesterol, HDL cholesterol, and total cholesterol. The lipogenesis pathway is activated, while the protein CES1 is inhibited in these rats. Lansoprazole can alleviate hepatic lipid deposition in hypercholesterolemia models by inducing CYP1A. These findings suggest CYP1A as a potential regulator of cholesterol homeostasis and provide a new perspective for hypercholesterolemia treatment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Xiao-Rong Lu, Ning Ma, Xi-Wang Liu, Shi-Hong Li, Zhe Qin, Li-Xia Bai, Ya-Jun Yang, Jian-Yong Li
Summary: This study found that AEE has therapeutic effects on hyperlipidemia through regulating amino acid metabolism, glutathione metabolism, energy metabolism, bile acid metabolism, and glycerophospholipid metabolism pathways. AEE decreases FXR and increases CYP7A1 in the liver, accelerating the conversion of cholesterol into bile acids and excretion in feces, thus providing potential molecular mechanisms and targets for anti-hyperlipidemia therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fatama Akter Chowdhury, Md Faridul Islam, Mahnaz Tabassum Prova, Mahbuba Khatun, Iffat Sharmin, Kazi Mazharul Islam, Md Kamrul Hassan, Md Abdullah Saeed Khan, Mohammed Mostafizur Rahman
Summary: The study found that the incidence of dyslipidemia was significantly higher in breast cancer patients compared to healthy women and patients with benign breast disease. Total cholesterol and BMI were identified as independent predictors of breast cancer risk among Bangladeshi women.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Sok Kuan Wong, Fitri Fareez Ramli, Adli Ali, Nurul Izzah Ibrahim
Summary: Metabolic syndrome is a cluster of metabolic dysregulations, including insulin resistance, obesity, hypertension, and dyslipidemia. This review summarizes the genetic information of cholesterol-related genes in metabolic syndrome, which may potentially serve as biomarkers for early prevention and management of the syndrome.
Article
Biochemistry & Molecular Biology
Qun Wang, Ling Wang, Abdultah Wenni Tian, Mingyue Song, Yong Cao, Jie Xiao
Summary: The concept of synergy in the food industry has led to the development of a strategy using a pickering double emulsion (PDE) system to deliver hydrophilic epigallocatechin-3-gallate (EGCG) and lipophilic lycopene (LYC) separately or together to induce a synergistic hypolipidemic effect. The study found that EGCG improved the physical stability of PDE while LYC had a negative impact. All groups showed a significant reduction in serum and liver cholesterol and weight of tissue fats. The enhanced bioaccessibility of EGCG and LYC delivered by PDE strengthened their hypolipidemic properties through different pathways.
Article
Plant Sciences
Haixia Du, Chang Li, Zhixiong Wang, Yu He, Yu Wang, Huifen Zhou, Haitong Wan, Jiehong Yang
Summary: The study demonstrated that Danhong injection (DHI) significantly improved hyperlipidemia in high-fat diet-fed rats by reducing lipid levels, decreasing hepatic lipid accumulation, improving liver function, and reducing oxidative stress. The potential mechanism may involve the promotion of bile acid synthesis through the activation of the PPAR alpha-LXR alpha-CYP7A1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Yuanyuan Dong, Xiaoling Li, Yaling Liu, Jie Gao, Jinhui Tao
Summary: Hyperlipidemia, an independent risk factor for atherosclerosis, is often associated with lipid metabolism disorder. Taurine, a sulfur-containing nonessential amino acid abundant in marine foods, plays a crucial role in regulating lipid metabolism.
Article
Cell Biology
Jinyuan Wang, Shun Zhang, Linlin Hu, Yan Wang, Ke Liu, Jianghua Le, Yongpeng Tan, Tianlong Li, Haoxuan Xue, Yanhong Wei, Ou Zhong, Junhui He, Dan Zi, Xin Lei, Renhe Deng, Yafei Luo, Masong Tang, Mingxuan Su, Yichang Cao, Qingyou Liu, Zhihan Tang, Xiaocan Lei
Summary: Supplementation of PQQ effectively improves abnormal lipid metabolism and testicular spermatogenic function in obese mice. Transcriptome analysis shows that PQQ supplementation inhibits the high expression of PCSK9 and weakens NLRP3-mediated cell death, both of which have negative effects on T synthesis in LCs.
CELL DEATH & DISEASE
(2023)