期刊
ACS CATALYSIS
卷 8, 期 1, 页码 8-11出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b03458
关键词
iron catalysis; aliphatic C-H; hydrogen shift; remote functionalization; arylation
资金
- MEXT [KAKENHI 15H05754, 26708011]
Catalytic amounts of an iron(III) salt and a N-heterocyclic carbene ligand catalyze the arylation of 2-iodoalkylarenes with diphenylzinc selectively at the gamma C-H bond of the alkyl side chain. Several lines of evidence suggest that the iron catalyst reacts with the aryl iodide moiety of the substrate to generate an aryliron intermediate that behaves in a radical manner and cleaves the aliphatic C-H bond through 1,5-hydrogen transfer; the resulting alkyliron intermediate undergoes reductive elimination to give the arylated product.
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