Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

(2016) Sai Krishna Athuluri-Divakar et al.   CELL

Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape

(2016) Ji-Sun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Direct Modulation of Small GTPase Activity and Function

(2015) Philipp M. Cromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Ras Signaling by Blocking Ras-Effector Interactions with Cyclic Peptides

(2015) Punit Upadhyaya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative assessment of cellular uptake and cytosolic access of antibody in living cells by an enhanced split GFP complementation assay

(2015) Ji-sun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif

(2015) Du-San Baek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions

(2015) S. Fujita-Sato et al.   CANCER RESEARCH

Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis

(2015) Ye-Jin Kim et al.   JOURNAL OF CONTROLLED RELEASE

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice

(2015) Felix Unverdorben et al.   mAbs

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

(2015) J. C. Hunter et al.   MOLECULAR CANCER RESEARCH

Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening

(2015) Hye-Ji Choi et al.   PLoS One

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

(2015) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

(2015) Susan K. Fetics et al.   STRUCTURE

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Construction of a Large Synthetic Human Fab Antibody Library on Yeast Cell Surface by Optimized Yeast Mating

(2014) Du-San Baek et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Delivery of antibodies to the cytosol

(2014) Andrea LJ Marschall et al.   mAbs

A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

(2014) Dong-Ki Choi et al.   mAbs

Enhancement of the Tumor Penetration of Monoclonal Antibody by Fusion of a Neuropilin-Targeting Peptide Improves the Antitumor Efficacy

(2014) T.-H. Shin et al.   MOLECULAR CANCER THERAPEUTICS

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor

(2013) Sang Min Lim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics

(2013) Hong-Won Lee et al.   Nature Communications

Mutant and Wild-type Ras: Co-conspirators in Cancer

(2013) Tikvah K. Hayes et al.   Cancer Discovery

Metal-Bis(2-picolyl)amine Complexes as State 1(T) Inhibitors of Activated Ras Protein

(2012) Ina C. Rosnizeck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy

(2012) T. Nakanishi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

(2011) Megumi Kawamoto et al.   BMC CANCER

Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases

(2011) Kousuke Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interfering with RAS–effector protein interactions prevent RAS-dependent tumour initiation and causes stop–start control of cancer growth

(2010) T Tanaka et al.   ONCOGENE

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo

(2010) C.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity

(2009) Christina Kiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY