期刊
NATURE COMMUNICATIONS
卷 8, 期 -, 页码 1-9出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms15150
关键词
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资金
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- European Research Council, ERC [336493]
- Int. Research Staff Exchange Scheme (IRSES)
- National Sciences and Engineering Research Council of Canada (NSERC) [436381-2013]
- European Research Council (ERC) [336493] Funding Source: European Research Council (ERC)
A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.
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