Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH

Increased hydrophobic surface exposure in the cataract-related G18V variant of human γ S-crystallin

(2016) Domarin Khago et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Revisiting supersaturation as a factor determining amyloid fibrillation

(2016) Masatomo So et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

(2016) Cody L. Hoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract

(2016) Eugene Serebryany et al.   PROTEIN SCIENCE

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic A 42 aggregates linked with Alzheimers disease

(2016) J. Habchi et al.   Science Advances

Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c

(2015) Abhishek Mandal et al.   BIOPHYSICAL JOURNAL

Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein

(2015) Sergi Garcia-Manyes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

(2015) Edward J. Wild et al.   JOURNAL OF CLINICAL INVESTIGATION

Lanosterol reverses protein aggregation in cataracts

(2015) Ling Zhao et al.   NATURE

Pharmacological chaperone for  -crystallin partially restores transparency in cataract models

(2015) L. N. Makley et al.   SCIENCE

Cataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation

(2014) Yi-Bo Xi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative Analysis of Human γD-Crystallin Aggregation under Physiological and Low pH Conditions

(2014) Josephine W. Wu et al.   PLoS One

An alternative structural isoform in amyloid-like aggregates formed from thermally denatured human γD-crystallin

(2014) Sean D. Moran et al.   PROTEIN SCIENCE

Physical and structural basis for polymorphism in amyloid fibrils

(2014) Robert Tycko   PROTEIN SCIENCE

Amyloid Fiber Formation in Human γD-Crystallin Induced by UV–B Photodamage

(2013) Sean D. Moran et al.   BIOCHEMISTRY

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the cataract-causing P23T γD-crystallin mutant

(2013) Fangling Ji et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Human W42R γD-Crystallin Mutant Structure Provides a Link between Congenital and Age-related Cataracts

(2012) Fangling Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Assessing Polyglutamine Conformation in the Nucleating Event by Molecular Dynamics Simulations

(2012) Markus S. Miettinen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cataract-Causing Defect of a Mutant γ-Crystallin Proceeds through an Aggregation Pathway Which Bypasses Recognition by the α-Crystallin Chaperone

(2012) Kate L. Moreau et al.   PLoS One

Domain swapping and amyloid fibril conformation

(2012) Patrick C.A. van der Wel   Prion

Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human  D-crystallin amyloid fibrils

(2012) S. D. Moran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation

(2012) Y. Yoshimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein misfolding and aggregation in cataract disease and prospects for prevention

(2012) Kate L. Moreau et al.   TRENDS IN MOLECULAR MEDICINE

Global estimates of visual impairment: 2010

(2011) Donatella Pascolini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Amyloid-like Fibrils from a Domain-swapping Protein Feature a Parallel, in-Register Conformation without Native-like Interactions

(2011) Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aggregation of  -crystallins associated with human cataracts via domain swapping at the C-terminal  -strands

(2011) P. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase in Surface Hydrophobicity of the Cataract-Associated P23T Mutant of Human γD-Crystallin Is Responsible for Its Dramatically Lower, Retrograde Solubility

(2010) Ajay Pande et al.   BIOCHEMISTRY

SPARTA+: a modest improvement in empirical NMR chemical shift prediction by means of an artificial neural network

(2010) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Flexibility of Y145Stop Human Prion Protein Amyloid Fibrils Probed by Solid-State Nuclear Magnetic Resonance Spectroscopy

(2010) Jonathan J. Helmus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Structure of the Cataract-Causing P23T Mutant of Human γD-Crystallin Exhibits Distinctive Local Conformational and Dynamic Changes†,‡

(2009) Jinwon Jung et al.   BIOCHEMISTRY

Conformational diseases: Looking into the eyes

(2009) Alexei Surguchev et al.   BRAIN RESEARCH BULLETIN

β arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils

(2009) Andrey V. Kajava et al.   FASEB JOURNAL

Crystallin proteins and amyloid fibrils

(2008) H. Ecroyd et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetics of crystallins: Cataract and beyond

(2008) Jochen Graw   EXPERIMENTAL EYE RESEARCH

Further Conventions for NMR Shielding and Chemical Shifts (IUPAC Recommendations 2008)

(2008) Robin K. Harris et al.   MAGNETIC RESONANCE IN CHEMISTRY

Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy

(2008) Martin Margittai et al.   QUARTERLY REVIEWS OF BIOPHYSICS