Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Effects of Bitter Compounds on the Taste Transduction Channels TRPM5 and IP3 Receptor Type 3

(2014) M. Gees et al.   CHEMICAL SENSES

Insulin release: the receptor hypothesis

(2014) Willy J. Malaisse   DIABETOLOGIA

Definition, Classification and Diagnosis of Diabetes Mellitus

(2014) W. Kerner et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Sweeteners from plants—with emphasis on Stevia rebaudiana (Bertoni) and Siraitia grosvenorii (Swingle)

(2013) Rahul S. Pawar et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

TRP Channels as Targets for Therapeutic Intervention in Obesity: Focus on TRPV1 and TRPM5

(2013) R. Kyle Palmer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes

(2012) F. Baeke et al.   DIABETOLOGIA

Human Psychometric and Taste Receptor Responses to Steviol Glycosides

(2012) Caroline Hellfritsch et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice

(2012) John I. Glendinning et al.   PHYSIOLOGY & BEHAVIOR

Non-Caloric Sweeteners, Sweetness Modulators, and Sweetener Enhancers

(2012) Grant E. DuBois et al.   Annual Review of Food Science and Technology

Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes

(2011) Caroline Ketterer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genome-wide evidence for local DNA methylation spreading from small RNA-targeted sequences in Arabidopsis

(2011) Ikhlak Ahmed et al.   NUCLEIC ACIDS RESEARCH

Triphenylphosphine Oxide Is a Potent and Selective Inhibitor of the Transient Receptor Potential Melastatin-5 Ion Channel

(2010) R. Kyle Palmer et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

TRPM5 regulates glucose-stimulated insulin secretion

(2010) Lili R. Brixel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T1r3 and α-Gustducin in Gut Regulate Secretion of Glucagon-like Peptide-1

(2009) Zaza Kokrashvili et al.   Annals of the New York Academy of Sciences

Taste perception of monosodium glutamate and inosine monophosphate by129P3/J and C57BL/6ByJ mice

(2009) Yuko Murata et al.   PHYSIOLOGY & BEHAVIOR

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

(2009) Yuko Nakagawa et al.   PLoS One

Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K+-channels*

(2008) R. Abudula et al.   DIABETES OBESITY & METABOLISM

Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes

(2008) R L Young et al.   GUT

Stevioside and related compounds: Therapeutic benefits beyond sweetness

(2008) Varanuj Chatsudthipong et al.   PHARMACOLOGY & THERAPEUTICS

The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions

(2007) Karel Talavera et al.   FASEB JOURNAL