Neuronal control of peripheral insulin sensitivity and glucose metabolism

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity

(2017) Sophie Marie Steculorum et al.   Cell Reports

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans

(2016) Paul Lee et al.   Cell Metabolism

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

(2016) Eleanor Raffan et al.   Cell Metabolism

The Brain–to–Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions

(2016) Wilfredo Rosario et al.   DIABETES

Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis

(2016) Sangho Yu et al.   JOURNAL OF NEUROSCIENCE

Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism

(2016) Sarah A. Stanley et al.   NATURE

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

(2016) Henning Fenselau et al.   NATURE NEUROSCIENCE

Functional identification of a neurocircuit regulating blood glucose

(2016) Thomas H. Meek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

(2016) João-Paulo G. Camporez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

(2016) Ken-ichiro Nakajima et al.   Nature Communications

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity

(2016) A. Christine Hausen et al.   Cell Reports

Physical limits to magnetogenetics

(2016) Markus Meister   eLife

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?: Figure 1

(2015) Dale S. Edgerton et al.   DIABETES

Regulation of Glucose Tolerance and Sympathetic Activity by MC4R Signaling in the Lateral Hypothalamus

(2015) Donald A. Morgan et al.   DIABETES

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans

(2015) Ellen A. Schur et al.   Obesity

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

(2015) Mark A. Smith et al.   Cell Reports

Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding

(2014) Merly C. Vogt et al.   CELL

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons

(2014) Hongxia Ren et al.   DIABETES

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

(2014) M. Heni et al.   DIABETES

Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study

(2014) Kathryn E. Berkseth et al.   ENDOCRINOLOGY

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

(2014) Eric D Berglund et al.   NATURE NEUROSCIENCE

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

(2014) Tevye J. Stachniak et al.   NEURON

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

(2014) Eva Tsaousidou et al.   Cell Reports

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Glut4 expression defines an insulin-sensitive hypothalamic neuronal population

(2014) Hongxia Ren et al.   Molecular Metabolism

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin

(2013) Teppei Fujikawa et al.   Cell Metabolism

Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

(2013) Yan-Chuan Shi et al.   Cell Metabolism

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

(2013) Zachary Gerhart-Hines et al.   NATURE

Hypothalamic glucagon signaling inhibits hepatic glucose production

(2013) Patricia I Mighiu et al.   NATURE MEDICINE

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding

(2013) J. H. Jennings et al.   SCIENCE

Hypothalamic glucagon signals through the KATP channels to regulate glucose production

(2013) Mona A. Abraham et al.   Molecular Metabolism

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

(2012) Aurélie Joly-Amado et al.   EMBO JOURNAL

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

(2012) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of KATP channels suppresses glucose production in humans

(2011) Preeti Kishore et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

(2011) Tim Klöckener et al.   NATURE NEUROSCIENCE

Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action

(2010) F. Thomas Wunderlich et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

(2010) Jonathan P. German et al.   ENDOCRINOLOGY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake

(2008) D. A. Sandoval et al.   DIABETES

Starvation after AgRP neuron ablation is independent of melanocortin signaling

(2008) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA