Review
Biochemistry & Molecular Biology
Xi Liu, Jimin Xu, Jia Zhou, Qiang Shen
Summary: Cancer is a major global health issue, with chemotherapy being the primary treatment option. Oridonin and its derivatives have shown promise in overcoming therapeutic resistance in cancer treatment, with potential as clinical trial drug candidates.
Article
Cell Biology
Zhifu Gui, Zhenguo Zhao, Qi Sun, Guoyi Shao, Jianming Huang, Wei Zhao, Yuting Kuang
Summary: Long non-coding RNA FEZF1-AS1 is upregulated in gastric cancer tissues and cell lines, and is associated with chemoresistance. High expression of FEZF1-AS1 is an independent predictor for poor overall survival in gastric cancer patients, potentially regulating multi-drug resistance through modulating autophagy in gastric cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vishal Singh, Tayyaba Afshan, Pankaj Tyagi, Pritish Kumar Varadwaj, Amaresh Kumar Sahoo
Summary: Multi-target therapies are a viable option to overcome drug-resistant cancer cells. With the use of a single drug against multiple structurally similar sites, it modulates several vital cellular pathways and reduces the usage of multiple drugs. However, drug resistance against anti-cancer agents targeting topoisomerase II has been observed, leading to the proposal of multi-target therapies to overcome different resistance mechanisms. This review discusses the binding cavity characteristics for drug interactions, potent inhibitors, and drug resistance mechanisms in various types of cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Armelle T. Mbaveng, Godloves F. Chi, Idrios N. Bonsou, Japheth O. Ombito, Samuel O. Yeboah, Victor Kuete, Thomas Efferth
Summary: Tetrapleura tetraptera and some of its constituents, particularly compound 7, exhibit cytotoxic effects against multiple cancer cell lines, suggesting their potential as natural products for cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Rebar N. Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar, Alireza Isazadeh, Ramin Aslaminabad, Morteza Akbari
Summary: Balanced cell death and survival pathways, including anastasis, play a critical role in cell development and homeostasis. Anastasis is a natural cell recovery pathway that promotes the survival of damaged or tumor cells, and contributes to the development of malignancy and drug resistance.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Cell Biology
Renjun Gu, Yawen Xia, Pengfei Li, Defang Zou, Keqin Lu, Lang Ren, Hongru Zhang, Zhiguang Sun
Summary: Gastric cancer is a common type of cancer with surgery as the main treatment method. However, it is expensive and painful, and patients often experience recurrence. Ferroptosis, a form of cell death dependent on iron, provides a new perspective in cancer therapy. This review summarizes the latest findings on ferroptosis regulation in gastric cancer, discusses the potential of drugs and genes in inducing ferroptosis for treatment and drug resistance, explores the relationship between ferroptosis and the tumor microenvironment in gastric cancer, and suggests areas for future research to accelerate the clinical utility of ferroptosis induction as a treatment strategy for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Xinguang Cao, Rui Li, Huihua Xiong, Jinfang Su, Changqing Guo, Tianqi An, Hong Zong, Ruihua Zhao
Summary: Among the four Pt(IV) complexes, complex 14 shows promising potential in reversing cisplatin resistance and enhancing anticancer efficiency through multiple mechanisms. Its low systematic toxicity makes it a potential novel P-gp-mediated MDR modulator with increased tumor inhibition compared to cisplatin and oxaliplatin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Gastric cancer is a common malignancy with poor prognosis. Gastric cancer stem cells (GCSCs) are closely associated with drug resistance, recurrence, and metastasis, indicating their potential as therapeutic targets for gastric cancer. However, the relationship and mechanism between GCSCs and gastric cancer still require further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Lulu Zhang, Yue Xiao, Ruijie Yang, Siyi Wang, ShuangXin Ma, Jianling Liu, Wei Xiao, Yonghua Wang
Summary: Using a systems pharmacology approach, this study revealed that PRGRC may influence the development of gastric cancer by modulating apoptosis and inflammation pathways, providing a new direction for analyzing the mechanism of Traditional Chinese Medicine.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Stefano Ughetto, Cristina Migliore, Filippo Pietrantonio, Maria Apicella, Annalisa Petrelli, Laura D'Errico, Stefania Durando, Daniel Moya-Rull, Sara E. Bellomo, Sabrina Rizzolio, Tania Capeloa, Salvatore Ribisi, Maurizio Degiuli, Rossella Reddavid, Ida Rapa, Uberto Fumagalli, Stefano De Pascale, Dario Ribero, Carla Baronchelli, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Stefania Manenti, Maria Bencivenga, Michele Sacco, Claudia Castelli, Salvatore Siena, Andrea Sartore-Bianchi, Federica Tosi, Federica Morano, Alessandra Raimondi, Michele Prisciandaro, Annunziata Gloghini, Silvia Marsoni, Antonino Sottile, Ivana Sarotto, Anna Sapino, Caterina Marchio, Paola Cassoni, Simonetta Guarrera, Simona Corso, Silvia Giordano
Summary: This study demonstrates that in patients with HER2-amplified gastric cancer, a dual HER2 blockade is crucial for optimal efficacy, leading to complete and durable responses in most cases. A selected subpopulation of HER2-hyper-amplified GC patients could greatly benefit from this treatment strategy.
Review
Oncology
Na Wang, Qingyun Mei, Ziwei Wang, Lu Zhao, Dou Zhang, Dongying Liao, Jinhui Zuo, Hongxia Xie, Yingjie Jia, Fanming Kong
Summary: Gastric cancer is a prevalent and difficult-to-treat malignant tumor. Antibody-drug conjugates hold promise as a novel therapeutic option, but drug resistance is a challenge.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Purab Pal, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: The imbalance between cell proliferation and cell death is a classic hallmark of cancer, and ceramide, a bioactive sphingolipid, is implicated in cancer. In addition to its effects on cell death and therapeutic efficacy, ceramide turnover to downstream sphingolipids plays an equally important role in driving pro-tumorigenic phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)