Article
Oncology
Hanqun Zhang, Shisheng Tan, Chunju Fang, Qi Zhang, Xue Cao, Yuncong Liu
Summary: This study explores the role of PD-1/PD-L1 in the evaluation of concurrent chemoradiotherapy efficacy and prognosis in cervical cancer patients. The results suggest that PD-1/PD-L1 may be a potential indicator for evaluating the efficacy and prognosis of CCRT in cervical cancer, providing potential targets for its treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Chunyi Shen, Zhen Zhang, Yonggui Tian, Feng Li, Lingxiao Zhou, Wenyi Jiang, Li Yang, Bin Zhang, Liping Wang, Yi Zhang
Summary: The study demonstrated that combining SFN with CAR-T cells enhanced cytotoxicity and antitumor functions by modulating the PD-1/PD-L1 pathway, suggesting a promising strategy for cancer immunotherapy.
Article
Engineering, Biomedical
Xuewei Luo, Guicheng Du, Yufei Long, Mengchao Zheng, Bingye Chen, Weiting Li, Guoliang Yan, Zhongquan Qi, Tianshu Lan
Summary: This study aims to investigate whether DC-derived exosomes (DEX) containing donor antigens (H2b) and high levels of PD-L1 expression can suppress graft rejection. It is demonstrated that DEXPDL1+ can present donor antigens and PD-L1 co-inhibitory signals to H2b-reactive T cells, prolonging the survival of heart grafts from B6 (H2b) mice. Furthermore, DEXPDL1+ treatment provides a new vehicle for presenting co-inhibitory signals to donor-specific T cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Lili Song, Shikai Liu, Sufen Zhao
Summary: This study found that the combination of RAD001 and PD-1 blockade can increase the radiosensitivity of cervical cancer cells by inhibiting the PI3K/AKT/mTOR pathway and promoting cell autophagy.
Article
Biochemistry & Molecular Biology
Andrzej Kowalski, Katarzyna Malinowska, Jurek Olszewski, Hanna Zielinska-Blizniewska
Summary: The interaction of PD-1 and PD-L1 in laryngeal tumors allows cancer cells to escape from the immune system. Gene expression of PD-1 and PD-L1 was significantly higher in tumor tissue compared to unchanged mucosa, with higher expression levels associated with larger tumor sizes. These findings suggest potential for targeted immunotherapy with anti-PD1 and anti-PD-L1 monoclonal antibodies in treating laryngeal tumors.
Article
Allergy
Zhi-Chao Wang, Yin Yao, Cai-Ling Chen, Cui-Lian Guo, Hong-Xia Ding, Jia Song, Zhe-Zheng Wang, Nan Wang, Xue-Li Li, Bo Liao, Yang Yang, Di Yu, Zheng Liu
Summary: PD-1(high) CXCR5(-)CD4(+) T cells contribute to local immunoglobulin production independent of ectopic lymphoid tissues in nasal polyps.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Chia-Jung Li, Li-Te Lin, Ming-Feng Hou, Pei-Yi Chu
Summary: Significant progress has been made in understanding the role of PD-L1 in breast cancer, especially in TNBC. Early clinical trials of PD-L1/PD-1 inhibitors have shown efficacy in refractory metastatic breast cancer patients, particularly in TNBC. Mechanisms and factors influencing the immunoediting process have been summarized and analyzed in detail.
Article
Biotechnology & Applied Microbiology
Jinlin Zhang, Mingyue Wang, Doudou He, Liang Zhang, Tianqing Liu, Kaikai Wang
Summary: This study reports a novel delivery system that enhances immune response by targeting PD-L1 and alleviates T cell exhaustion by inhibiting TOX expression. The system demonstrates excellent anti-tumor and antimetastatic effects, providing a potential strategy for treating cold tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Immunology
Rilan Bai, Jiuwei Cui
Summary: Antibodies targeting PD-1/PD-L1 have been considered breakthrough therapies for cancer. In addition to T cell-driven immune responses, blocking PD-1/PD-L1 may also enhance the function and activity of NK cells, which are often overlooked in previous studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Soumi Sadhu, Sanjay Kumar, Dipendra Kumar Mitra, Beenu Joshi
Summary: Pathogen detection is the most important stage in activating an appropriate immune response during an infection. In leprosy patients, the expression patterns of TLR2 and TLR4 are associated with the immunosuppressive markers PD-1 and PD-L1, and blocking the interaction of PD-1 and PD-L1 can improve immune activation status.
Review
Oncology
Chao Cheng, Lingdun Zhuge, Xin Xiao, Siyuan Luan, Yong Yuan
Summary: As the predominant treatment option for advanced esophageal cancer, PD-1 and PD-L1 inhibitors provide new hope to clinical practice. However, some patients do not respond to this therapy and most initially sensitive patients eventually develop resistance. Therefore, it is critical to understand the mechanisms of resistance and explore efficient strategies to overcome it, in order to expand the benefit of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Benjawan Wudtiwai, Kanchanok Kodchakorn, Thuzar Hla Shwe, Peraphan Pothacharoen, Thanyaluck Phitak, Raksa Suninthaboonrana, Prachya Kongtawelert
Summary: In this study, brazilein was found to reduce cell viability, induce apoptosis, and inhibit EMT and PD-L1 expression in breast cancer cells through suppression of phosphorylation of AKT, NF-kappa B, and GSK3 beta/beta-catenin signaling pathways. Moreover, brazilein also diminished migration ability by inhibiting MMP-9 and MMP-2 activation. Thus, brazilein might delay cancer progression and could be a potential therapeutic option in breast cancer patients with high levels of EMT and PD-L1.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Fu Li, Jingrong Li, Ke Yin, Juan Zhang, Zhen-hu Li, Liang Lu, Yuan-wu Bao, Zhen Qin, Yong Zheng, Bao-tian Yang, Jing Li, Xinzhong Wang
Summary: The PD-1 antibody CS1003 is a novel humanized IgG4 PD-1 monoclonal antibody that can effectively inhibit immune regulation, promote T cell activity, and exhibit anti-tumor activity. Preclinical studies have shown the potential clinical application value of CS1003 in cancer immunotherapy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Ying Zhou, Jinmei Zhou, Xiaopeng Hao, Haoyuan Shi, Xuejie Li, Anqi Wang, Zhiyuan Hu, Yanlian Yang, Zefei Jiang, Tao Wang
Summary: This study aims to investigate the predictive and stratification value of PD-L1 expression on CTCs in metastatic breast cancer patients treated with anti-PD-1 immunotherapy. The results showed that PD-L1 expression on CTCs can predict therapeutic response and clinical outcomes, providing a valuable predictive and prognostic biomarker for breast cancer patients.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Medicine, Research & Experimental
Keywan Mortaezaee, Jamal Majidpoor
Summary: CD8+ T cells play a crucial role in combating cancer, but their infiltration and effector function are often impaired in cancer patients, leading to defective immunity and resistance to immunotherapy. The exclusion and exhaustion of CD8+ T cells are major factors contributing to the limited durability of immune checkpoint inhibitor therapy. Identifying and targeting factors responsible for defective CD8+ T cell infiltration and function could provide a promising supplementary approach in patients undergoing anti-PD-1/PD-L1 therapy. Recent development of bispecific antibodies against PD-(L)1 and key factors within the tumor microenvironment holds great potential in enhancing the effectiveness and safety of cancer immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)