Article
Oncology
Zhuoan Cheng, Chunlai Lu, Hui Wang, Ning Wang, Shaohua Cui, Chengtao Yu, Cun Wang, Qiaozhu Zuo, Siying Wang, Yuanyuan Lv, Ming Yao, Liyan Jiang, Wenxin Qin
Summary: The study found that LHFPL3-AS2 is a novel long noncoding RNA that is significantly decreased in non-small cell lung cancer (NSCLC) tissues. Low levels of LHFPL3-AS2 expression were highly correlated with poor overall survival, TNM stage, and metastasis of NSCLC patients. Enhanced expression of LHFPL3-AS2 inhibited NSCLC invasion and metastasis.
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Hiroshi Masutani
Summary: Thioredoxin-interacting protein (Txnip) is a critical cancer suppressor and regulator of energy metabolism; the mechanism of action of Txnip remains to be fully elucidated and requires further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Cell Biology
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Summary: Chondrosarcomas, the most common malignancy of cartilage, are linked to genetic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. The presence of IDH mutations in enchondromas, the benign precursor lesions, suggests that these mutations occur early in the development of malignancy. Our studies on mutant IDH chondrosarcomas and mutant Idh mice have found that glycogen is deposited exclusively in mutant cells, and its utilization influences tumor cell behavior and energy pathways. The interaction between mutant IDH1 and hypoxia-inducible factor 1a (HIF1a) appears to regulate key enzymes in glycogen metabolism, suggesting a critical role for glycogen in enchondromas and chondrosarcomas.
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Editorial Material
Hematology
Ian J. Majewski
Summary: The study investigates how loss of the tumor suppressor gene Cux1 modulates DNA repair activity in the hematopoietic compartment and contributes to the pathogenesis of therapy-related myeloid neoplasms.
Article
Oncology
Hatice Ulku Osmanbeyoglu, Drake Palmer, April Sagan, Eleonora Sementino, Michael J. Becich, Joseph R. Testa
Summary: Malignant pleural mesothelioma (MPM) is an aggressive cancer with no effective treatment. Genetic alterations in tumor suppressor genes are associated with patient survival and immune responses in MPM. BAP1 alterations alone are linked to better survival and an immunogenic subtype, while CDKN2A/B alterations consistently lead to adverse clinical outcomes.
Review
Pharmacology & Pharmacy
He Fang, Hanyang Li, Hang Zhang, Shu Wang, Shuang Xu, Li Chang, Yongsheng Yang, Ranji Cui
Summary: This article summarises the significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers. It also describes the possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Renjie Wang, Qi Li, Xiaolei Chu, Nan Li, Haiqian Liang, Feng He
Summary: This study identifies lncBIRC3-OT as an important regulator promoting the progression of glioma. Down-regulation of lncBIRC3-OT inhibits cell proliferation and invasion in glioma cells. Mechanistically, lncBIRC3-OT guides RELA protein to the STC1 promoter, initiating STC1 transcription and ultimately promoting glioma progression.
Review
Biochemistry & Molecular Biology
David Eisenbarth, Y. Alan Wang
Summary: Glioblastoma (GBM) is a highly deadly and treatment-resistant cancer due to its heterogeneity at both cellular and microenvironmental levels. The recent advancements in sequencing technologies have revealed the diversity of cell states in GBM, which hampers accurate classification and effective treatments for the disease. Moreover, GBM heterogeneity is influenced by both intrinsic factors and differs between new and recurrent cases, as well as treatment-naive and experienced patients. Understanding and unraveling the complex cellular network underlying GBM heterogeneity is essential for developing new strategies to combat this deadly disease.
Article
Chemistry, Analytical
Pengcheng Sun, Kai Niu, Haiying Du, Ruixin Li, Jiping Chen, Xianbo Lu
Summary: The study presents an electrochemical gene-sensor capable of rapidly and sensitively detecting tumor related TP53 gene mutation hotspots. The biosensor achieves high sensitivity and specificity, making it a powerful tool for early diagnosis and detection of cancer.
Article
Biotechnology & Applied Microbiology
Yuefu Han, Xingqiao Wen, Xiaojuan Li, Dong Chen, Lian Peng, Bin Lai, Hongcai Huang
Summary: The study revealed that hsa_circ_0075542 is downregulated in prostate cancer tissues, and its overexpression can suppress cell proliferation, reduce migration and invasiveness, and promote apoptosis. Furthermore, hsa_circ_0075542 targets the miR-1197/HOXC11 axis, alleviating the tumor-promoting effect of miR-1197 overexpression.
Article
Biochemistry & Molecular Biology
Zhi Nie, Shan Cai, Zhimin Wei, Yanxi Li, Li Bian, Chenyang Wang, Chunyan Wang
Summary: SH3BGRL2 is weakly expressed in GBM and IDH1 wildtype GBM, and its ectopic expression inhibits GBM cell growth, migration, and GSCs self-renewal both in vitro and in vivo, by suppressing key regulators like SOX2 and CD133. This suggests SH3BGRL2 has potential as a biomarker and therapeutic target for glioma patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Assunta De Rienzo, Lucian R. Chirieac, Yin P. Hung, David T. Severson, Samuel Freyaldenhoven, Corinne E. Gustafson, Nhien T. Dao, Claire Meyerovitz, Michela E. Oster, Roderick Jensen, Beow Y. Yeap, Raphael Bueno, William G. Richards
Summary: This study identified significant associations among different BAP1 staining patterns and subgroups of MPM tumors, suggesting that the role of BAP1 in tumor progression may be more complex. Cytoplasmic BAP1 staining was identified as a potential indicator of favorable prognosis in non-epithelioid MPM.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raul Nicolas Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi
Summary: This study developed a method to detect genomic variants causing splicing changes using transcriptome data alone. By applying this method to a large dataset, the researchers identified a significant number of genomic variants associated with intron retention. Additionally, by exploring the positional relationships with known disease variants, they extracted potential disease-associated variants.
NATURE COMMUNICATIONS
(2022)