期刊
ONCOLOGY LETTERS
卷 15, 期 2, 页码 1869-1873出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.7451
关键词
Licochalcone A; breast cancer; autophagy; phosphoinositide 3-kinase/RAC-alpha serine-threonine-protein kinase/mammalian target of rapamycin
类别
Previous studies have demonstrated that Licochalcone A possesses anti-inflammatory, anticancer, anti-bacterial, anti-malarial and anti-parasitic activities. In the present study the potential anticancer effects of Licochalcone A on MCF-7 cells were investigated. Licochalcone A significantly decreased cell viability and promoted autophagy and apoptosis, as demonstrated by an MTT assay, acridine orange staining and Annexin V-fluorescein isothiocyanate staining, respectively. Western blot analyses demonstrated that Licochalcone A treatment activated the LC3-II signaling pathway while suppressing the phosphoinositide 3-kinase (PI3K)/RAC-alpha seri ne-threonine-protein kinase (A kt)/mammalian target of rapamycin (mTOR) signaling pathway. In addition, Licochalcone A significantly increased caspase-3 activity and significantly decreased B-cell lymphoma-2 expression. The results from the present study indicate that Licochalcone A inhibits PI3K/Akt/mTOR activation, and promotes autophagy and apoptosis in MCF-7 cells.
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