期刊
ONCOLOGY LETTERS
卷 13, 期 5, 页码 2867-2872出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2017.5851
关键词
FOXO3a; phosphorylation; acetylation; SIRT1; transactivation
类别
资金
- Hubei Province Natural Science Foundation of China [2016CFB180]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2016Y07]
- Jingzhou Science and Technology Development Planning Project [JZKJ15063]
- National Natural Science Foundation of China [31470072]
Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a tumor suppressor and longevity factor. The precise regulation of FOXO3a trans activation of target genes is achieved via post-translational modifications (PTMs) and specific protein-protein interactions. The multiple types of PTMs that FOXO3a undergoes, including phosphorylation, acetylation, methylation and ubiquitination, serve important roles in directing its subcellular localization and transcription activity, which arc central to the integration of insulin/growth factor signaling and oxidative/nutrient stress signaling. The present review summarizes the modifications of FOXO3a that occur via phosphorylation and acetylation. In addition, the synergistic effect of multiple phosphorylations on FOXO3a and the crosstalk between phosphorylation and acetylation in the regulation of FOXO3a are discussed. These discussions may highlight potential strategies for the prevention of cancer and aging.
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