Article
Biochemistry & Molecular Biology
Yunping Lu, Weifen Zheng, Xiao Rao, Yinggan Du, Jianbo Xue
Summary: This study aimed to investigate the binding of microRNA-9-5p and STARD13 in lung adenocarcinoma (LUAD) cells and explore their effect on the malignant progression of LUAD. Bioinformatics analysis was used to identify differentially expressed miRNAs and predict potential target genes. The results showed that microRNA-9-5p could promote the malignant progression of LUAD cells, while STARD13 could inhibit it. Dual-luciferase gene assay confirmed the direct targeting relationship between microRNA-9-5p and STARD13.
BIOCHEMICAL GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Bo Hu, Fei Xiao
Summary: In this study, we found that F-circEA-2a and premature miR-3940-5p were overexpressed in gastric adenocarcinoma (GA), while mature miR-3940-5p was under-expressed. F-circEA-2a suppressed miR-3940-5p maturation and promoted GA cell proliferation. MiR-3940-5p directly bound to F-circEA-2a and their interaction affected cell proliferation in GA.
Article
Biochemistry & Molecular Biology
Meigui Wang, Jiahao Shao, Xiaoxiao Zhang, Zheliang Liu, Tao Tang, Guanhe Chen, Siqi Xia, Kaisen Zhao, Zhe Kang, Wenqiang Sun, Xianbo Jia, Jie Wang, Songjia Lai
Summary: Obesity is a global health issue and there is increasing evidence supporting the role of microRNAs (miRNAs) in its development. In this study, miR-383-5p was found to be highly expressed in the perirenal fat of rabbits fed a high-fat diet, and it was discovered that miR-383-5p may be involved in lipid metabolism and adipogenesis by targeting RAD51AP1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniel G. Henriques, Renan Lyra Miranda, Romulo Sperduto Dezonne, Luiz Eduardo Wildemberg, Aline Helen da Silva Camacho, Leila Chimelli, Leandro Kasuki, Elisa B. Lamback, Alexandro Guterres, Monica R. Gadelha
Summary: This study identified miRNAs associated with resistance to fg-SRLs treatment in acromegaly using miRNA sequencing and bioinformatic analysis. It was found that miR-181a-5p, miR-181b-5p, and miR-383-5p were differentially expressed, with miR-181a-5p and miR-181b-5p downregulated and miR-383-5p upregulated in the uncontrolled group. ROC curve analysis showed that miR-383-5p had an NPV of 84.3% and a PPV of 84.5%. Thus, these miRNAs can serve as biomarkers and tools to guide clinical decisions in response to fg-SRLs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiulin Jiang, Yixiao Yuan, Lin Tang, Juan Wang, Dahang Zhang, William C. Cho, Lincan Duan
Summary: The expression of miRNA-30a-5p is significantly decreased in LUAD and is associated with clinical outcomes and immune cell infiltration. Furthermore, miRNA-30a-5p has been found to inhibit cell proliferation and migration in LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan, Wei-Fei Fan
Summary: The study revealed that Circ_0001361 was up-regulated in LUAD tissues and cells, while miR-525-5p was down-regulated. Functional experiments demonstrated that Circ_0001361 promoted LUAD cell growth and metastasis. Mechanistically, Circ_0001361 acted as a sponge for miR-525-5p to up-regulate the downstream target VMA21 level, contributing to the malignant phenotypes of LUAD cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Wei Jiang, Yaozhou He, Zijian Ma, Yu Zhang, Chengpeng Zhang, Nianpeng Zheng, Xing Tang
Summary: circ_0008234 in LUAC inhibits disease progression through a competitive endogenous RNA mechanism, potentially serving as a biomarker and therapeutic target for LUAC treatment.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Lin Tang, Yixiao Yuan, Haoqing Zhai, Juan Wang, Dahang Zhang, Huasu Liang, Yulin Shi, Lincan Duan, Xiulin Jiang
Summary: This study found that miR-125b-5p is downregulated in non-small cell lung cancer (LUAD) and is associated with poor prognosis. The study also revealed that miR-125b-5p is mainly involved in cell proliferation and immune regulation, playing an important role in the progression of LUAD. Moreover, overexpression of miR-125b-5p significantly inhibits cell proliferation, migration, and invasion, and induces cell apoptosis in LUAD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jixin Jiang, Hui Ge, Jie Yang, Yunfei Qiao, Xingxiang Xu, Yanming Geng
Summary: This study found that circRNA_PTPRA significantly reduces lung cancer cell proliferation and induces apoptosis by regulating the expression of miR-582-3p.
Article
Oncology
Fengjie Zhu, Zhe Ren
Summary: This study found that Icariin can target the miR-205-5p/PTEN axis to suppress the malignant cell phenotype and inhibit the growth of lung cancer.
Article
Oncology
Yuzhen Huang, Ganzhu Feng
Summary: The study revealed that miR-423-5p aggravated lung adenocarcinoma by downregulating CADM1 expression. Overexpression of CADM1 significantly repressed proliferation, migration, and invasion of LUAD cells. CADM1 was identified as a target gene of miR-423-5p, and their expression levels were negatively correlated in LUAD cell lines.
Article
Cell Biology
Yunping Lu, Xiao Rao, Weifen Zheng, Yinggan Du, Jianbo Xue, Kan Huang
Summary: This study revealed that MANCR inhibits the killing effect of NK cells on LUAD by targeting and downregulating miRNA-30d-5p. This provides new insights into antitumor therapy based on the tumor microenvironment.
CELLULAR MICROBIOLOGY
(2022)
Article
Oncology
David E. Cohn, Mateus C. Barros-Filho, Brenda C. Minatel, Michelle E. Pewarchuk, Erin A. Marshall, Emily A. Vucic, Adam P. Sage, Nikita Telkar, Greg L. Stewart, Igor Jurisica, Patricia P. Reis, Wendy P. Robinson, Wan L. Lam
Summary: Patterns of oncofetal microRNA expression were identified in fetal lung and lung adenocarcinoma samples, but absent in adult non-malignant lung samples. These microRNAs have potential as biomarkers for cancer detection and targets for novel therapies, representing important regulators of both normal development and tumourigenesis.
Article
Biochemistry & Molecular Biology
Yi Liu, Gongming Zhang, Hao Chen, Hua Wang
Summary: Our study revealed that DUXAP8 promotes tumor progression in LUAD by targeting miR-26b-5p. This provides a novel therapeutic target for the diagnosis and therapy of LUAD.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Kaiyi Tao, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, WeiMin Mao
Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.