Review
Genetics & Heredity
Wen-Jian Liu, Yuan Zhao, Xu Chen, Man-Li Miao, Ren-Quan Zhang
Summary: Esophageal cancer is a widespread cancer of the digestive system, with two main subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA). Conventional treatments for esophageal cancer have significant side effects, leading to a need for novel drugs with multiple targets, good efficacy, low side effects, and low cost. Epigenetics, including DNA methylation, histone modifications, non-coding RNA regulation, chromatin remodelling, and nucleosome localization, offers new opportunities for the prevention and treatment of esophageal cancer. This paper focuses on the close link between esophageal cancer and epigenetic modifications, aiming to facilitate precise and personalized treatment of the disease.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Qiang Guo, Xiao-Li Liu, Ni Jiang, Wen-Jun Zhang, Shao-Wen Guo, Heng Yang, Yan-Mei Ji, Jun Zhou, Jia-Long Guo, Jun Zhang, Hua-Song Liu
Summary: APOC1 is found to be overexpressed in esophageal cancer (ESCA) and is associated with prognosis and diagnosis, making it a potential biomarker. Additionally, APOC1 expression is linked to the immune microenvironment in ESCA and can affect cell proliferation, migration, and invasion.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Yun Chen, Jianliang Chen, Dainian Guo, Peixuan Yang, Shuang Chen, Chengkuan Zhao, Chengcheng Xu, Qiuzhen Zhang, Chaoxian Lin, Shilong Zhong, Shuyao Zhang
Summary: This study investigates the effects of tryptophan (TRP) metabolism on the clinical outcomes of esophageal cancer (EC) in a Chinese population cohort. The findings suggest that the TRP metabolic profile is associated with susceptibility, tumor metastasis, and overall survival (OS) in patients with EC. The study provides insights into targeting endogenous TRP metabolism as a potential therapeutic intervention for EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Hongxing Nan, Lisha Zhou, Weihua Liang, Jin Meng, Ke Lin, Man Li, Jun Hou, Lianghai Wang
Summary: Elevated expression of CCL20 in esophageal cancer is associated with poor prognosis and metastatic potential, as well as with promoter hypomethylation in tumor cells. Imbalance among CD4(+) T cell subtypes and abnormal CCL20 expression in the tumor microenvironment are observed during tumorigenesis. Targeting CCL20 may be a promising therapeutic approach for esophageal cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Medicine, Research & Experimental
Runzhang Liang, Xiaosong Li, Weiquan Li, Xiao Zhu, Chen Li
Summary: DNA methylation, catalyzed by DNMT, plays a role in lung cancer pathogenesis and progression, with smoking influencing gene methylation status and increasing the risk of central lung cancer. It is crucial in the mechanisms of lung cancer, early diagnosis, and treatment, but faces challenges in clinical application due to limitations in methylation markers and sample tests. The future development of DNA methylation may need to focus on improving efficiency and sensitivity in liquid biopsy for lung cancer diagnosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Xuan Li, Du Cai, Yaoyi Huang, Yumo Xie, Dingcheng Shen, Ze Yuan, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Huichuan Yu, Xiaolin Wang
Summary: This study developed a DNA methylation biomarker to evaluate the prognosis of colorectal cancer (CRC) by identifying hypermethylated genes in cancer tissue from Illumina EPIC methylation arrays. The study found that RIMS2 was frequently hypermethylated and lowly expressed in CRC, and its methylation was associated with less frequent KRAS mutation and high differentiation. RIMS2 methylation showed independent predictive value for survival outcome and could predict prognosis better when combined with KRAS status.
Article
Genetics & Heredity
Shixuan Liu, Yanbin Liu, Xi Zhang, Xuanlin Song, Boxiang Zhang, Yong Zhang
Summary: This study analyzed the expression, genetic alterations, protein phosphorylation, promoter methylation, immune infiltration, and enrichment of DDX5 in various cancers. The findings suggest that DDX5 plays a potential oncogenic role in diverse tumor types and is closely associated with tumor immunity and diagnosis.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Wenping Ma, Zhaoshi Bao, Zenghui Qian, Kenan Zhang, Wenhua Fan, Jianbao Xu, Changyuan Ren, Ying Zhang, Tao Jiang
Summary: This study identified LRRFIP1 as a potential prognostic biomarker for glioma by analyzing the correlation between methylation genes and clinical prognosis in glioblastoma (GBM) patients. LRRFIP1 was found to be highly expressed in WHO IV, mesenchymal, and IDH wild-type subtypes. Additionally, GO and KEGG pathway analyses were performed to explore the functions and related mechanisms of LRRFIP1 in gliomas.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Huimei Wang, Yiping Zhang, Lin Chen, Yufeng Liu, Chen Xu, Dongxian Jiang, Qi Song, Haixing Wang, Liyan Wang, Yu Lin, Yuanmei Chen, Junqiang Chen, Yuanji Xu, Yingyong Hou
Summary: This study found significant differential expression of most of the 23 regulators in ESCA tissues. LASSO regression analysis identified 7 m6A-related factors, and the risk model was associated with biological functions such as base metabolism, DNA repair, and mismatch repair. A nomogram was created to predict the prognosis of ESCA patients, and bioinformatics analysis of human ESCA and normal tissues was performed using qRT-PCR.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Farah J. Nassar, Zahraa S. Msheik, Rihab R. Nasr, Sally N. Temraz
Summary: Colorectal cancer is a deadly disease with a high mortality rate worldwide; early detection is crucial for improving survival outcomes; traditional CRC diagnostic tests have limitations, and methylated circulating tumor DNA shows promise as a potential biomarker worth further investigation.
CLINICAL EPIGENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Yajun Deng, Wenhua Yuan, Enhui Ren, Zuolong Wu, Guangzhi Zhang, Qiqi Xie
Summary: This study established a methylated lncRNA signature for predicting osteosarcoma patient survival based on comprehensive analysis of DNA methylation and transcriptome data. The signature was validated using Kaplan-Meier and ROC analysis, showing higher prediction accuracy than known biomarkers, and was independent of clinicopathological factors.
Article
Genetics & Heredity
Dan Luo, QingLing Yang, HaiBo Wang, Mao Tan, YanLei Zou, Jian Liu
Summary: This study identified 1565 DEGs and 3754 DEMGs, with 369 differentially expressed at both gene and methylation levels. 12 signature genes were identified, including VEGFC, FBP1, NR3C1, NFE2L2, and DFNA5, which combined with clinical data to create a novel prognostic model for GC. This model effectively categorized GC patients into high- and low-risk groups, which was confirmed in a validation dataset.
BMC MEDICAL GENOMICS
(2021)
Article
Medical Laboratory Technology
Peikun Ding, Bin Peng, Guofeng Li, Xuefeng Sun, Guangsuo Wang
Summary: GNPNAT1 and methylated GNPNAT1 are biomarkers for the diagnosis and prognosis of lung cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, General & Internal
Jun Hou, Yinfeng Yang, Honglei Gao, Ting Ouyang, Qiwei Liu, Ran Ding, Hongxing Kan
Summary: Esophageal cancer (ESCA) is a highly aggressive malignant tumor with a high incidence and mortality rate worldwide. This study investigated the expression and function of chromobox family members (CBXs) in ESCA and found that they may serve as potential prognostic biomarkers for ESCA patients. Furthermore, the study revealed a correlation between CBX expression and immune cell infiltration, as well as cell cycle and apoptosis pathways.
Article
Medicine, General & Internal
Mohamed Samir A. Zaki, Muhammad Alaa Eldeen, Waleed K. K. Abdulsahib, Ayed A. A. Shati, Youssef A. A. Alqahtani, Saleh M. M. Al-Qahtani, Hassan M. M. Otifi, Ashwag Asiri, Hesham M. M. Hassan, Hebatallah Emam Mohammed Ahmed, Samy A. A. Dawood, Amr Negm, Refaat A. A. Eid
Summary: Emerging research has found that the protein CEP55 may function as an oncogene in various human malignancies. However, there has been no comprehensive analysis conducted to investigate the role and behavior of CEP55 as an oncogene in different types of cancer. This study aims to provide a detailed analysis of CEP55, including its expression in different cancers, correlation with cancer stage, impact on patient survival, genetic alterations, methylation status, influence on immune cell infiltration, response to chemotherapeutic agents, and underlying molecular mechanisms. The findings suggest that CEP55 is upregulated in cancer tissues compared to normal controls and this upregulation is associated with poor prognosis in multiple forms of cancer. It also affects immune cell infiltration, chemokine levels, and response to anticancer drugs. Therefore, CEP55 could serve as a potential predictive marker and therapeutic target for cancer treatment.
Article
Surgery
Akira Nonogaki, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: This study suggests that the preoperative neutrophil-to-platelet ratio (NPR) can serve as a prognostic factor in gastric cancer patients with positive peritoneal lavage cytology in the absence of other non-curative factors.
Article
Gastroenterology & Hepatology
Takamichi Igarashi, Suguru Yamada, Yui Hoshino, Kenta Murotani, Hayato Baba, Hideki Takami, Isaku Yoshioka, Kazuto Shibuya, Yasuhiro Kodera, Tsutomu Fujii
Summary: In patients with unresectable locally advanced pancreatic ductal adenocarcinoma (PDAC), the normalization of CA19-9 levels and good nutritional status during treatment were important prognostic factors for surgical outcome after induction gemcitabine along with nab-paclitaxel (GnP) and subsequent chemoradiotherapy (CRT).
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Oncology
Keisuke Okuno, Shuichi Watanabe, Souvick Roy, Mitsuro Kanda, Masanori Tokunaga, Yasuhiro Kodera, Yusuke Kinugasa, Ajay Goel
Summary: We established a miRNA-based liquid biopsy signature that can reliably predict early recurrence in gastric cancer patients by analyzing miRNA expression profiling. Additionally, a model combining the miRNA signature, microsatellite instability (MSI) status, and tumor size exhibited better predictive performance and was successfully validated in another independent cohort. Finally, we translated the miRNA signature into a liquid biopsy assay and demonstrated its independence as a predictor for early recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Yuki Ito, Takashi Miwa, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera
Summary: This study aimed to build a risk score for predicting deaths from other causes after gastrectomy in gastric cancer patients. Nine characteristics were identified as risk factors for poor survival, and patients were classified into Low-, Intermediate-, and High-risk groups based on their risk scores. The 5-year survival rates were significantly different among the three risk groups, highlighting the usefulness of this risk score for predicting deaths from other causes after curative gastrectomy.
Article
Oncology
Mitsuro Kanda, Masanori Terashima, Takahiro Kinoshita, Hiroshi Yabusaki, Masanori Tokunaga, Yasuhiro Kodera
Summary: This study investigated the feasibility of using endoscopic biopsy samples for next-generation sequencing (NGS) and compared the results with those obtained from surgical samples. The results showed that NGS is applicable to analyzing biopsy samples of gastric cancer (GC) acquired through endoscopic biopsy and the data obtained were highly consistent with those from surgical samples.
Article
Surgery
Katsuhisa Hirano, Takamichi Igarashi, Kenta Murotani, Nobutake Tanaka, Taro Sakurai, Takeshi Miwa, Toru Watanabe, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii
Summary: This study aimed to investigate the efficacy and safety of routine intravenous administration of acetaminophen after highly invasive hepatobiliary pancreatic surgery, particularly pancreatoduodenectomy. The analgesic effects and adverse events of scheduled intravenous administration of acetaminophen were evaluated in 179 patients who underwent open pancreatoduodenectomy. The results showed that scheduled intravenous administration of acetaminophen did not affect postoperative liver function and had a good analgesic effect after pancreatoduodenectomy.
Article
Gastroenterology & Hepatology
Kazuto Shibuya, Nana Kimura, Toru Watanabe, Katsuhisa Hirano, Takamichi Igarashi, Isaku Yoshioka, Toshio Doi, Norihito Naruto, Kyo Noguchi, Tsutomu Fujii
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Chemistry, Medicinal
Suresh Awale, Hayato Baba, Nguyen Duy Phan, Min Jo Kim, Juthamart Maneenet, Koichi Sawaki, Mitsuro Kanda, Tomoyuki Okumura, Tsutomu Fujii, Takuya Okada, Takahiro Maruyama, Takahiro Okada, Naoki Toyooka
Summary: Pancreatic tumors in an austere tumor microenvironment activate adaptive pathways to tolerate nutrient starvation and promote aggressive malignancy. Plumbagin, a plant-derived compound, has shown cytotoxicity against pancreatic cancer cells in nutrient-deprived conditions. 2-(cyclohexylmethyl)-plumbagin was identified as the most promising compound that inhibits cancer cell survival under nutrient-deprived conditions by targeting the PI3K/Akt/mTOR pathways. In vivo studies using xenograft mouse models confirmed the effectiveness of this compound in inhibiting tumor growth. Plumbagin derivatives, such as 2-(cyclohexylmethyl)-plumbagin, hold great potential for the development of anticancer drugs targeting the tumor's austerity microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Nguyen Duy Phan, Ashraf M. Omar, Ikue Takahashi, Hayato Baba, Tomoyuki Okumura, Johji Imura, Takuya Okada, Naoki Toyooka, Tsutomu Fujii, Suresh Awale
Summary: Pancreatic tumors are often characterized by hypoxia and severe nutrient deprivation, making anticancer drugs targeting rapidly proliferating cells ineffective. The search for novel agents that can eliminate cancer cells' adaptations to nutrition starvation, known as antiausterity agents, is promising. The natural product (+)-nicolaioidesin C (Nic-C) has shown potent antiausterity activity against pancreatic cancer cells in vitro, and its racemic form (synthesized Nic-C) inhibited tumor growth and signaling pathways in a human pancreatic cancer xenograft model. Metabolomic profiling suggests Nic-C affects amino acid and sphingolipid metabolism.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Gastroenterology & Hepatology
Atsushi Oba, Marco Del Chiaro, Tsutomu Fujii, Keiichi Okano, Thomas F. Stoop, Y. H. Andrew Wu, Aya Maekawa, Yuta Yoshida, Daisuke Hashimoto, Toshitaka Sugawara, Yosuke Inoue, Minoru Tanabe, Masayuki Sho, Takashi Sasaki, Yu Takahashi, Ippei Matsumoto, Naoki Sasahira, Yuichi Nagakawa, Sohei Satoi, Richard D. Schulick, Yoo-Seok Yoon, Jin He, Jin-Young Jang, Christopher L. Wolfgang, Thilo Hackert, Marc G. Besselink, Kyoichi Takaori, Yoshifumi Takeyama
Summary: Locally advanced pancreatic cancer (LAPC) has traditionally been considered unresectable, but conversion surgery after successful chemotherapy or chemoradiation therapy has shown favorable results. An international consensus meeting on conversion surgery for LAPC was recently held, where experts agreed that cancer biology has surpassed locoregional resectability and emphasized the importance of institutional and international collaboration.
Article
Multidisciplinary Sciences
Takuto Fujii, Shushi Nagamori, Pattama Wiriyasermkul, Shizhou Zheng, Asaka Yago, Takahiro Shimizu, Yoshiaki Tabuchi, Tomoyuki Okumura, Tsutomu Fujii, Hiroshi Takeshima, Hideki Sakai
Summary: Mutations in the human ATP13A2 gene are associated with the development of Parkinson's disease. This study reveals that ATP13A2 acts as a H+/K+ transporting protein in lysosomes, which prevents alkalization of lysosomes and accumulation of alpha-synuclein.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Mina Fukasawa, Toru Watanabe, Haruyoshi Tanaka, Ayaka Itoh, Nana Kimura, Kazuto Shibuya, Isaku Yoshioka, Kenta Murotani, Kenichi Hirabayashi, Tsutomu Fujii
Summary: The frequency and prognosis of positive peritoneal washing cytology (CY1) in resectable pancreatic ductal adenocarcinoma (R-PDAC) remains unclear. This study found that patients with CY1 had a significantly better prognosis than those with distant metastasis, and the prognosis of CY1 patients converted to CY-negative was similar to that of CY0 patients.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Takamichi Igarashi, Mina Fukasawa, Toru Watanabe, Nana Kimura, Ayaka Itoh, Haruyoshi Tanaka, Kazuto Shibuya, Isaku Yoshioka, Kenichi Hirabayashi, Tsutomu Fujii
Summary: The study aimed to evaluate the results of staging laparoscopy (SL) and treatment efficacy in patients with positive peritoneal washing cytology (CY1) who have pancreatic ductal adenocarcinoma (PDAC). The results showed that the rates of CY-negative conversion, conversion surgery, and CY1 occurrence were correlated with the degree of local progression.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Masakazu Nagamori, Takamichi Igarashi, Nana Kimura, Mina Fukasawa, Toru Watanabe, Katsuhisa Hirano, Haruyoshi Tanaka, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii
Summary: This is a case of a 100-year-old man with no specific symptoms who was diagnosed with an operable pancreatic cancer. Preoperative assessment and comprehensive treatment were done to improve his quality of life and prevent complications. Surgical intervention was successful and the patient was discharged without major complications.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Takahiro Shinozuka, Mitsuro Kanda, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera
Summary: The study reveals that high levels of STX3 mRNA and protein expression are significantly associated with lymph node involvement, pathological stage, and poor overall survival in patients with esophageal squamous cell carcinoma (ESCC), suggesting their potential use as prognostic biomarkers.
