☆ 4.5 Editorial Material

The end of the beginning: epigenetic variation in utero as a mediator of later human health and disease

EPIGENOMICS (2017)

获取全文
添加到收藏夹

期刊

EPIGENOMICS
卷 9, 期 3, 页码 217-221

出版社

FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0007

关键词

DNA methylation; DOHaDE; epigenetic; in utero; environment; fetal programming; noncommunicable disease; pregnancy

类别

Genetics & Heredity

资金

  1. FP7 EarlyNutrition project
  2. NHMRC (Aust) Senior Research Fellowship
  3. Australian Postgraduate research award
  4. Victorian Government Operational Infrastructure Support Scheme

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Clinical Neurology

Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schuller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones

Summary: Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related death in children aged 0-14 years. A newly identified CNS tumor type characterized by PLAGL1/2 amplification and a lack of recurrent genetic alterations has been described. These tumors are composed of primitive embryonal-like cells and are associated with intermediate survival, but the cell of origin and optimal treatment strategies are yet to be determined.

ACTA NEUROPATHOLOGICA (2023)

添加到收藏夹
Article Immunology

In-utero HIV exposure and cardiometabolic health among children 5-8 years: findings from a prospective birth cohort in South Africa

Angela M. Bengtson, Jennifer Pellowski, Stephen McGarvey, Rae McGinty, Maresa Botha, Tiffany Burd, David Burgner, Toby Mansell, Heather J. Zar

Summary: This prospective cohort study aimed to assess whether in-utero HIV exposure is associated with adverse cardiometabolic health outcomes among children aged 5-8. The study included HIV-exposed but uninfected (HEU) and HIV-unexposed children from a South African birth cohort. The results showed minimal differences in growth and metabolic outcomes between HEU and HIV-unexposed children, suggesting overall reassuring findings. However, continued monitoring of cardiometabolic health is important as these children enter adolescence and establish long-term risk trajectories.

AIDS (2023)

添加到收藏夹
Article Medicine, General & Internal

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study

Ahmed Elhakeem, Justiina Ronkainen, Toby Mansell, Katherine Lange, Tuija M. M. Mikkola, Binisha H. H. Mishra, Rama J. J. Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. G. Eriksson, Marjo-Riitta Jaervelin, Romy Gaillard, Vincent W. V. Jaddoe, Terho Lehtimaeki, Olli T. T. Raitakari, Richard Saffery, Melissa Wake, John Wright, Sylvain Sebert, Deborah A. A. Lawlor

Summary: This study examined the associations between common pregnancy and perinatal complications and offspring metabolic traits using data from eight population-based cohort studies. The findings indicate that these complications are mainly associated with metabolic traits in newborns, with little evidence of long-term impact on older offspring.

BMC MEDICINE (2023)

添加到收藏夹
Article Environmental Sciences

Increased maternal non-oxidative energy metabolism mediates association between prenatal di-(2-ethylhexyl) phthalate (DEHP) exposure and offspring autism spectrum disorder symptoms in early life: A birth cohort study

Sarah Thomson, Katherine Drummond, Martin O'Hely, Christos Symeonides, Chitra Chandran, Toby Mansell, Richard Saffery, Peter Sly, Jochen Mueller, Peter Vuillermin, Anne-Louise Ponsonby

Summary: This study investigated whether maternal and child central carbon metabolism is involved in the development of autism spectrum disorder (ASD). They found that higher prenatal levels of di-(2-ethylhexyl) phthalate (DEHP) were associated with upregulation of maternal non-oxidative energy metabolism pathways and increased ASD symptoms in children at 2 and 4 years of age.

ENVIRONMENT INTERNATIONAL (2023)

添加到收藏夹
Article Cardiac & Cardiovascular Systems

Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Y. Huang, Toby Mansell, Carina Rodrigues, Federica Asta, Sophia M. Blaauwendraad, Siri E. Haberg, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Fergus P. McCarthy, Irwin K. M. Reiss, Franca Rusconi, Theodosia Salika, Muriel Tafflet, Xiu Qiu, Bjorn O. Asvold, David Burgner, Jerry K. Y. Chan, Luigi Gagliardi, Romy Gaillard, Barbara Heude, Maria C. Magnus, George Moschonis, Deirdre Murray, Scott M. Nelson, Daniela Porta, Richard Saffery, Henrique Barros, Johan G. Eriksson, Tanja G. M. Vrijkotte, Deborah A. Lawlor

Summary: This study aimed to examine the associations of assisted reproductive technology (ART) conception with offspring cardiometabolic health outcomes and whether these associations differ with age. The researchers found small and statistically non-significant differences in offspring cardiometabolic outcomes between ART-conceived and naturally conceived offspring. The study concluded that these findings should reassure individuals receiving ART, but longer-term follow-up is needed to investigate changes in the risks of hypertension, dyslipidaemia, and cardiovascular disease over adulthood.

EUROPEAN HEART JOURNAL (2023)

添加到收藏夹
Article Otorhinolaryngology

Association of Polygenic Risk Scores for Hearing Difficulty in Older Adults With Hearing Loss in Mid-Childhood and Midlife A Population-Based Cross-sectional Study Within the Longitudinal Study of Australian Children

Jing Wang, Katherine Lange, Valerie Sung, Angela Morgan, Richard Saffery, Melissa Wake

Summary: Although more than 200 genes have been associated with monogenic congenital hearing loss, the polygenic contribution to hearing decline across the life course remains largely unknown. This study found an association between polygenic risk scores for self-reported hearing difficulty among adults and measured hearing and speech reception abilities in mid-childhood and early midlife.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2023)

添加到收藏夹
Article Pediatrics

Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories

Li Wen, Huijia Fu, Richard Saffery, Chao Tong, Yamin Liu, Mark D. Kilby, Hongbo Qi, Philip N. Baker

Summary: This study measured the concentrations of adiponectin and leptin in the cord blood of monochorionic twins with selective intrauterine growth restriction (IUGR). The findings showed that cord blood adiponectin concentrations were negatively associated with IUGR, while cord blood leptin concentrations were significantly lower in IUGR twins. Furthermore, adiponectin was negatively associated with height increments in the first 6 months, and leptin was inversely associated with weight and height increments in the first 6 months, as well as weight and height at 6 and 24 months. These results indicate the influence of adiponectin and leptin in cord blood on IUGR and childhood growth trajectories.

PEDIATRIC OBESITY (2023)

添加到收藏夹
Article Neurosciences

Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells

Elisa Weiss, Anna Schruefer, Carolina Tocantins, Mariana Simoes Diniz, Boris Novakovic, Anke S. van Bergen, Azra Kulovic-Sissawo, Richard Saffery, Reinier. A. A. Boon, Ursula Hiden

Summary: High gestational weight gain (GWG) is associated with impaired wound healing of neonatal endothelial colony forming cells (ECFCs). A specific long non-coding RNA (lncRNA), KLRK1-AS1, was found to be downregulated in neonatal ECFCs from pregnancies with higher GWG, and its knockdown resulted in further impairment of barrier recovery. These findings suggest a potential role for lncRNAs, particularly KLRK1-AS1, in regulating neonatal ECFC function and may provide insights into the link between GWG and cardiovascular risk factors.

JOURNAL OF PHYSIOLOGY-LONDON (2023)

添加到收藏夹
Article Biochemistry & Molecular Biology

Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming

Cindy Pham, Sarah Thomson, Sung-Tong Chin, Peter Vuillermin, Martin O'Hely, David Burgner, Samuel Tanner, Richard Saffery, Toby Mansell, Sze Bong, Elaine Holmes, Peter D. Sly, Nicola Gray, Anne-Louise Ponsonby, Barwon Infant Study Invest Grp

Summary: Childhood mental disorders are becoming increasingly common, and higher maternal oxidative stress during pregnancy is linked to these disorders. Social and prenatal environmental factors contribute to maternal oxidative stress and childhood mental disorders. Future studies are needed to further understand the role of early-life oxidant damage in childhood mental disorders.

MOLECULAR PSYCHIATRY (2023)

添加到收藏夹
Article Endocrinology & Metabolism

Change in adiposity is associated with change in glycoprotein acetyls but not hsCRP in adolescents with severe obesity

Toby Mansell, Siroon Bekkering, Danielle Longmore, Costan G. Magnussen, Amanda Vlahos, Brooke E. Harcourt, Zoe McCallum, Kung-Ting Kao, Matthew A. Sabin, Markus Juonala, Richard Saffery, David P. Burgner, Christoph Saner

Summary: This study demonstrates associations between severe obesity and inflammatory biomarkers in children and adolescents, both cross-sectionally and longitudinally. Specifically, glycoprotein acetyls and white blood cell count may be useful in assessing the severity of chronic inflammation related to obesity over time.

OBESITY RESEARCH & CLINICAL PRACTICE (2023)

添加到收藏夹
Meeting Abstract Biochemistry & Molecular Biology

Prenatal programming of autism spectrum disorder: Bisphenol a and aromatase-directed male brain development

Kristina Vacy, Christos Symeonides, Sarah Thomson, Sam Tanner, Nicole Rinehart, Bruce Tonge, Toby Mansell, Boris Novakovic, LIea Delbridge, Shilpi Dixit, Christopher Reid, Hui Kheng Chua, Jessalynn Chia, Feng Chen, Tae Hwan Kim, Gabriel Bernasochi, Anthony El-Bitar, Deborah Dewey, Peter Vuillermin, Mimi L. K. Tang, Peter Sly, Richard Saffery, Jochen Mueller, Anne-Louise Ponsonby, Wah Chin Boon

JOURNAL OF NEUROCHEMISTRY (2023)

添加到收藏夹
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.