期刊
EPIGENOMICS
卷 9, 期 5, 页码 689-700出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0179
关键词
acceleration; age; aging; centenarians; DNAmage; epigenetic clock; longevity
资金
- National Health and Medical Research Council (NHMRC) [630593, 109308]
- NHMRC [310667, APP1021269, 401184]
- NHMRC/Australian Research Council Strategic Award [401162]
- NHMRC Project Grant [1045325]
Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.
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