期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 8, 期 5, 页码 555-559出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.7b00098
关键词
Porphyrin; cyclodextrin; photodynamic therapy; photosensitizer
资金
- JSPS [JP16H04133, JP16K13982]
- Electric Technology Research Foundation of Chugoku
- Grants-in-Aid for Scientific Research [16H04133, 16K13982] Funding Source: KAKEN
Water-soluble cyclodextrin (CyD) complexed with porphyrin derivatives with different substituents in the meso-positions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step toward the optimization of porphyrin derivatives as photosensitizers.
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