期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 8, 期 8, 页码 853-857出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.7b00200
关键词
MRSA; antibacterial peptide; oxacillin; potentiator
资金
- Defense Advanced Research Projects Agency [W911NF-10-0299]
- Arizona State University crowd funding campaign
- National Institutes of Health [AI091917]
- Silicon Valley Community Foundation
One proposed solution to the crisis of antimicrobial resistant (AMR) infections is the development of molecules that potentiate the activity of antibiotics for AMR bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Rather than develop broad spectrum compounds, we developed a peptide that could potentiate the activity of a narrow spectrum antibiotic, oxacillin. In this way, the combination treatment could narrowly target the resistant pathogen and limit impact on host flora. We developed a peptide, ASU014, composed of a S. aureus binding peptide and a S. aureus inhibitory peptide conjugated to a branched peptide scaffold, which has modest activity against S. aureus but exhibits synergy with oxacillin for MRSA both in vitro and in a MRSA skin infection model. The low concentration of ASU014 and sub-MIC concentration of oxacillin necessary for activity suggest that this molecule is a candidate for future medicinal chemistry optimization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据