Article
Urology & Nephrology
Dan-yang Yin, Gai-ling Hou, Xiao-qing Yang, Liang-liang Bi, Xiao-feng Mei, Meng-ke Bai, Li Zhou, Shan Zhu, Yan-jie Huang
Summary: This study aimed to explore the advantages of urinary matrix metalloproteinase-7 (MMP-7) in assessing renal tubular injury in patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), compared with urinary cystatin C (CysC) and retinol-binding protein (RBP). The results showed that urinary MMP-7 levels were higher in MCD patients compared to the control group, while urinary CysC and RBP levels did not significantly increase. In FSGS patients, urinary levels of MMP-7, CysC, and RBP were significantly elevated compared to the control group and MCD patients. This study demonstrates that urinary MMP-7 levels can assess the severity of renal tubular injury in both MCD and FSGS patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Transplantation
Lihong Bu, James Mirocha, Mark Haas
Summary: This study examined whether the IgG/albumin staining ratio in protein reabsorption droplets could help distinguish minimal change disease (MCD) from primary focal segmental glomerulosclerosis (FSGS). The results showed that a ratio ≤0.33 was more likely to indicate MCD, while a ratio of 1.0 was more likely to indicate FSGS.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Mahmoud M. Sobh, Ghada El Kannishy, Fatma Moustafa, Riham Eid, Nashwa Hamdy, Samar Tharwat
Summary: This study found that detachment of podocytes can be accurately detected by light microscopy, providing important information for diagnosis and prognosis.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Xiaojie Gong, Jing Huang, Yimiao Zhang, Fang Wang, Xin Wang, Liqiang Meng, Xuyang Cheng, Gang Liu, Zhao Cui, Minghui Zhao
Summary: This study found that elevated urinary CD80 is associated with mild pathological changes and steroid-dependent cases in adults with primary FSGS.
Review
Urology & Nephrology
Cheng Xue, Bo Yang, Jing Xu, Chenchen Zhou, Liming Zhang, Xiang Gao, Bing Dai, Shengqiang Yu, Zhiguo Mao, Changlin Mei, Chenggang Xu
Summary: Rituximab (RTX) may be an effective and relatively safe alternative for the treatment of adult frequent-relapsing or steroid-dependent nephrotic syndrome patients. Patients with minimal change disease have a higher complete remission rate with RTX, while those with focal segmental glomerulosclerosis have a lower remission rate and further investigation is needed on long-term adverse events.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Takaya Ozeki, Michio Nagata, Takayuki Katsuno, Koji Inagaki, Kazunori Goto, Sawako Kato, Yoshinari Yasuda, Naotake Tsuboi, Shoichi Maruyama
Summary: This study analyzed the clinical implication of unclassified segmental lesions in Japanese adult patients with nephrotic syndrome compared to Columbia-classified FSGS. The results showed that unclassified segmental lesions may have equivalent clinical impact as Columbia classification of FSGS, with similar treatment responses and no significant difference in the decline of eGFR.
Article
Medicine, General & Internal
Long Tang, Zhen Cai, Su-Xia Wang, Wen-Jing Zhao
Summary: This article reports a case of a patient transitioning from minimal change disease (MCD) to focal segmental glomerulosclerosis (FSGS) and explores the relationship between the two diseases. Occupational exposure may have contributed to the worsening of the patient's condition.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Urology & Nephrology
Lan Lan, Yuxin Lin, Binfeng Yu, Yin Wang, Hong Pan, Huijing Wang, Xiaowei Lou, Xiabing Lang, Qiankun Zhang, Lie Jin, Yi Yang, Liang Xiao, Jianghua Chen, Fei Han
Summary: Rituximab has been shown to be effective and safe in adult FR/SDNS patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), maintaining disease remission and minimizing corticosteroid exposure.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Immunology
Ibrahim Batal, Pascale Khairallah, Astrid Weins, Nicole K. Andeen, Michael B. Stokes
Summary: Primary focal segmental glomerulosclerosis (FSGS) is a disease characterized by diffuse podocyte foot process effacement and nephrotic syndrome. It can recur after transplantation and is associated with immunogenetic factors. This study retrospectively investigated a cohort of kidney allograft recipients with primary FSGS and found a higher frequency of HLA-A30 antigen in patients with primary FSGS compared to healthy controls and deceased kidney donors. The study also revealed an association between donor HLA-A30 and recurrent FSGS in transplant patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Wenqiang Zhi, Xiaoli Yuan, Wenzhu Song, Guorong Jin, Yafeng Li
Summary: This is the first report of fecal microbiota transplantation (FMT) in patients with chronic kidney disease. The patient experienced abnormal renal function and no proteinuria after medication, but FMT treatment stabilized renal function and reduced proteinuria. Additionally, FMT improved the patient's lipid profile.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Jarcy Zee, Michelle T. McNulty, Jeffrey B. Hodgin, Olga Zhdanova, Sangeeta Hingorani, Jonathan Ashley Jefferson, Keisha L. Gibson, Howard Trachtman, Alessia Fornoni, Katherine M. Dell, Heather N. Reich, Serena Bagnasco, Larry A. Greenbaum, Richard A. Lafayette, Debbie S. Gipson, Elizabeth Brown, Matthias Kretzler, Gerald Appel, Kamalanathan K. Sambandam, Katherine R. Tuttle, Dhruti Chen, Meredith A. Atkinson, Marie C. Hogan, Frederick J. Kaskel, Kevin E. Meyers, John O'Toole, Tarak Srivastava, Christine B. Sethna, Michelle A. Hladunewich, J. J. Lin, Cynthia C. Nast, Vimal K. Derebail, Jiten Patel, Suzanne Vento, Lawrence B. Holzman, Ambarish M. Athavale, Sharon G. Adler, Kevin Lemley, John C. Lieske, Jonathan J. Hogan, Crystal A. Gadegbeku, Fernando C. Fervenza, Chia-Shi Wang, Raed Bou Matar, Pamela Singer, Jeffrey B. Kopp, Laura Barisoni, Matthew G. Sampson
Summary: In this study, APOL1 risk variants were significantly associated with certain tissue changes in FSGS patients, while no significant correlations were found in the MCD cohort. This suggests that both one and two risk alleles may be associated with cellular/tissue changes in FSGS.
PEDIATRIC NEPHROLOGY
(2021)
Article
Urology & Nephrology
Pilar Aunon, Natalia Polanco, Maria Jose Perez-Saez, Emilio Rodrigo, Asuncion Sancho, Julio Pascual, Amado Andres, Manuel Praga
Summary: The recurrence rate of FSGS after kidney transplantation is related to the presence of nephrotic syndrome at the time of diagnosis and the effectiveness of pre-emptive rituximab treatment.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Medicine, General & Internal
Hamza Naciri Bennani, Lionel Elimby, Florian Terrec, Paolo Malvezzi, Johan Noble, Thomas Jouve, Lionel Rostaing
Summary: This study assessed graft survival in FSGS kidney-transplant recipients and compared patients with and without relapse. The results showed a recurrence rate of 47% for FSGS, and pretransplant prophylaxis did not seem to reduce the risk of relapse.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Ryo Zamami, Kentaro Kohagura, Kojiro Kinjyo, Takuto Nakamura, Takanori Kinjo, Masanobu Yamazato, Akio Ishida, Yusuke Ohya
Summary: This study investigated the association between glomerular diameter and FSGS lesions in CKD patients, finding that glomerular hypertrophy (Max GD >= 224 μm) is significantly associated with FSGS lesions and may reflect the limits of the compensatory process.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Article
Immunology
Julie Oniszczuk, Anissa Moktefi, Aude Mausoleo, Nicolas Pallet, Stephanie Malard-Castagnet, Slim Fourati, Khalil El Karoui, Dil Sahali, Thomas Stehle, Anna Boueilh, Marie-Christine Verpont, Marie Matignon, David Buob, Philippe Grimbert, Vincent Audard
Summary: This case study reports a renal transplant recipient who developed renal complications, including nephrotic syndrome and acute kidney injury, after contracting non-severe COVID-19. The renal biopsy revealed focal and segmental glomerulosclerosis lesions. The donor had high-risk apolipoprotein L1 gene variants, which may have contributed to the acute glomerular injury observed in the patient.
Review
Urology & Nephrology
Hewang Lee, Michael B. Fessler, Peng Qu, Jurgen Heymann, Jeffrey B. Kopp
Editorial Material
Urology & Nephrology
Samih H. Nasr, Jeffrey B. Kopp
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Xiangfei Cui, Jingqi Fu, Junjun Luan, Huimeng Qi, Congcong Jiao, Mengping Ran, Dongdong Wang, Xiangnan Hao, Yixiao Zhang, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Editorial Material
Urology & Nephrology
Edward D. Siew, Kathleen D. Liu, John Bonn, Vernon Chinchilli, Laura M. Dember, Timothy D. Girard, Tom Greene, Adrian F. Hernandez, T. Alp Ikizler, Matthew T. James, Kevin Kampschroer, Jeffrey B. Kopp, Marla Levy, Paul M. Palevsky, Neesh Pannu, Chirag R. Parikh, Michael V. Rocco, Samuel A. Silver, Heather Thiessen-Philbrook, Ron Wald, Yining Xie, Paul L. Kimmel, Robert A. Star
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek, Jeffrey B. Kopp
Article
Health Care Sciences & Services
Guillermo J. Aviles Mendoza, Kristen P. Finne, Francisco Torre Leon, Lisandro Montalvo Burke, Jessica Cabrera-Marquez, Ana M. Mercado Casillas, Grasiela Malave, Christopher Brown, Jeffrey Kelman, Jeffrey B. Kopp
Summary: In September 2017, two category 5 hurricanes, Irma and Maria, struck the Caribbean in quick succession, causing widespread devastation and medical infrastructure damage. Puerto Rico served as a safehaven for evacuees from the impacted islands, providing temporary shelter and medical assistance.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Urology & Nephrology
A. Parker Ruhl, Neal Jeffries, Yu Yang, Rakhi P. Naik, Amit Patki, Lydia H. Pecker, Bryan T. Mott, Neil A. Zakai, Cheryl A. Winkler, Jeffrey B. Kopp, Leslie A. Lange, Marguerite R. Irvin, Orlando M. Gutierrez, Mary Cushman, Hans C. Ackerman
Summary: This study found that increasing HBA copy number is associated with a greater prevalence of chronic kidney disease and incidence of end-stage kidney disease in a national longitudinal cohort of Black Americans.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Gabor Kokeny, Agnes Nemeth, Jeffrey B. Kopp, Weiping Chen, Andrew J. Oler, Anna Manzeger, Laszlo Rosivall, Miklos M. Mozes
Summary: Patients with chronic kidney disease and experimental animal models of kidney fibrosis show diverse progression rates. Genetic background plays a significant role in the progression of kidney fibrosis, possibly through altered EGR2 and TIMP-1 responses.
KIDNEY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Ya-Wen Yang, Bibek Poudel, Julia Frederick, Poonam Dhillon, Rojesh Shrestha, Ziyuan Ma, Junnan Wu, Koji Okamoto, Jeffrey B. Kopp, Sheri L. Booten, Danielle Gattis, Andrew T. Watt, Matthew Palmer, Mariam Aghajan, Katalin Susztak
Summary: This study aims to determine whether lowering risk variant APOL1 levels can protect mice from kidney disease development. By administering antisense oligonucleotides targeting APOL1 to podocyte-specific transgenic mice, efficient reduction of APOL1 levels was observed, resulting in protection against kidney disease.
Review
Urology & Nephrology
Parnaz Daneshpajouhnejad, Jeffrey B. Kopp, Cheryl A. Winkler, Avi Z. Rosenberg
Summary: Genetic coding variants in the APOL1 gene play an important role in kidney disease, particularly among individuals of sub-Saharan African ancestry. These variants lead to kidney dysfunction and require additional factors to trigger the disease. Current therapies are not sufficient to stop disease progression, and new targeted molecular therapies are being investigated.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Urology & Nephrology
Briana A. Santo, Darshana Govind, Parnaz Daneshpajouhnejad, Xiaoping Yang, Xiaoxin X. Wang, Komuraiah Myakala, Bryce A. Jones, Moshe Levi, Jeffrey B. Kopp, Teruhiko Yoshida, Laura J. Niedernhofer, David Manthey, Kyung Chul Moon, Seung Seok Han, Jarcy Zee, Avi Z. Rosenberg, Pinaki Sarder
Summary: A computational tool called PodoCount was developed for automated podocyte quantification in various experimental and clinical settings. The tool demonstrated high accuracy and significant correlation with disease state, proteinuria, and clinical outcome.
KIDNEY INTERNATIONAL REPORTS
(2022)
Editorial Material
Urology & Nephrology
Jeffrey B. Kopp, Jurgen Heymann
Summary: McNulty and colleagues have identified the glomerular transcriptional landscape of individuals with the APOL1 gene. They found that APOL1 gene expression was higher in individuals with a high-risk genetic status for APOL1. Additionally, STC1 and CCL18 were the most upregulated and downregulated genes in the glomeruli, respectively, and NKIRAS1 was identified as the most important hub gene. These findings provide insight into the disease pathways involved in APOL1-associated nephropathies.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Jeffrey B. Kopp, Teruhiko Yoshida
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Jeffrey B. B. Kopp, Kenneth Lempert, Kristen Finne
Summary: Access to essential medical care can be compromised by social disruptions, armed conflicts, and natural disasters. Successful response to these events requires prior planning, preparation, and rehearsal involving healthcare systems, professionals, patients, and their support networks. After-action evaluation is necessary to enhance future responses.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Myrna Serrano, Anvesha Srivastava, Gregory Buck, Bin Zhu, Laahirie Edupuganti, Esther Adegbulugbe, Divya Shankaranarayanan, Jeffrey B. Kopp, Dominic S. Raj
Summary: A low protein high fiber diet promotes the proliferation of saccharolytic bacteria and favors T-cell commitment toward regulatory T cells in a chronic kidney disease mouse model.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)