Article
Biochemistry & Molecular Biology
Donghao Shang, Yuting Liu, Zhenghao Chen
Summary: This study investigates the regulatory function of exosome-transmitted miR-128 and CCL18 on urothelial carcinomas (UCs). The results demonstrate that miR-128 inhibits the proliferation, invasion, and migration of UCs by regulating CCL18 secretion, and promotes apoptosis in UC cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Baozeng Chen, Lingling Zheng, Teng Zhu, Kai Jiao
Summary: This study found that FOXD3-AS1 enhances the expression of TXNIP by sponging miR-128, thereby inhibiting the Redd1/AKT/GSK3β/Nrf2 pathway during myocardial ischemia/reperfusion injury. Silencing FOXD3-AS1 can alleviate myocardial ischemia/reperfusion injury in vivo and in vitro.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Oncology
Xin Xu, Wenjing Jiang, Peng Han, Jingyan Zhang, Liquan Tong, Xueying Sun
Summary: The study identifies the potential therapeutic targets of the miR-128-3p/c-Met axis for overcoming Lenvatinib resistance in HCC. It demonstrates that miR-128-3p mimics can enhance the anti-tumor effects of Lenvatinib. These findings are significant for further understanding the mechanisms of Lenvatinib resistance and developing novel therapeutic strategies.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Review
Biochemistry & Molecular Biology
Marika Lanza, Salvatore Cuzzocrea, Salvatore Oddo, Emanuela Esposito, Giovanna Casili
Summary: Several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the accumulation of misfolded proteins known as proteinopathies. Changes in gene expression, particularly in noncoding RNAs like miR-128, which is highly expressed in mammalian brains, may play a role in these diseases. Targeting miR-128 could potentially alleviate the behavioral phenotype associated with these diseases, as it is involved in neuronal plasticity, cytoskeletal organization, and neuronal death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Qi Shang, Gengyang Shen, Guifeng Chen, Zhida Zhang, Xiang Yu, Wenhua Zhao, Peng Zhang, Honglin Chen, Kai Tang, Fuyong Yu, Jingjing Tang, De Liang, Xiaobing Jiang, Hui Ren
Summary: miR-128 is involved in cell proliferation, differentiation, migration, apoptosis, and survival, with implications in bone metabolism and muscle regeneration. Dysregulation of miR-128 may lead to musculoskeletal diseases. Research on miR-128 presents significant therapeutic potential and suggests future research directions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun You, Jiayi Li, Chunlin Ke, Yanru Xiao, Chuanhui Lu, Fakun Huang, Yanjun Mi, Rongmu Xia, Qiyuan Li
Summary: This study demonstrates that Linc00284 is upregulated in CRC tissues and cell lines, associated with tumor metastasis and poor clinical outcome in CRC patients. Serum expression levels of Linc00284 and miR-27a may serve as potential clinical biomarkers for CRC diagnosis.
Article
Genetics & Heredity
Wang Sheng, Weixi Guo, Fang Lu, Hongming Liu, Rongmu Xia, Feng Dong
Summary: Lung cancer is a malignant tumor with high incidence and mortality rates globally. Linc00284, a long non-coding RNA, is significantly upregulated in LC tissues and promotes cancer progression by regulating the miR-205-3p/c-Met axis.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Huili Li, Jiaxing Ding, Wei Liu, Xuehua Wang, Yu Feng, Hongquan Guan, Zhijian Chen
Summary: This study found that plasma exosomes derived from patients with acute myocardial infarction (AMI) (MI-Exo) can inhibit cell death in AMI by targeting the miR-26b-5p/SLC7A11 axis. MI-Exo exhibited a strong inhibitory effect on abnormal cell death after AMI, suggesting the potential therapeutic value of miR-26b-5p in controlling myocardial injury after AMI.
Article
Cell Biology
Weixin Sun, Xiang Wu, Peng Yu, Qian Zhang, Le Shen, Jiandong Chen, Huaqin Tong, Manlu Fan, Haibo Shi, Xiaohu Chen
Summary: This study demonstrates that lncAABR07025387.1 is highly expressed in myocardial ischemia/reperfusion (MI/R) injury and interacts with miR-205 to upregulate ACSL4-mediated ferroptosis. These findings highlight the role of lncAABR07025387.1 in MI/R injury and the therapeutic potential of lncRNAs for treating myocardial injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Youngmi Choi, Seung-Ho Hong
Summary: This study aimed to investigate the potential association between miR-200bT>C and miR-495A>C polymorphisms and susceptibility to hypertension. The results showed significant differences in the miR-495A>C genotype distributions between the hypertension and control groups, while no differences were found for the miR-200bT>C polymorphism. The combined genotypes of TC/CC and CC/CC for miR-200bT>C and miR-495A>C were associated with hypertension susceptibility. The study suggests that the miR-495A>C polymorphism and allelic combinations of miR-200bT>C/miR-495A>C may increase the risk of hypertension in a Korean population.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zhuoqun Meng, Jianing Lu, Guangcai Ge, Guang Wang, Ran Zhang, Yuhan Li, Shuang Guan, Jing Lu
Summary: The study found that ginsenoside Rb1 can reduce lipid accumulation in animals and cells induced by high-fat diet and palmitic acid. In addition, ginsenoside Rb1 also promotes autophagic flux and exerts its effects by regulating the transcription factor EB and miR-128, further promoting autophagic lipid degradation.
Article
Medicine, General & Internal
Shinan Liu, Shuai Gao, Zhaoyu Yang, Peng Zhang
Summary: The study showed that miR-128-3p can alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a potential novel treatment strategy for sepsis-induced ALI.
Article
Medicine, Research & Experimental
Qing Wang, Ming-Jiang Liu, Jie Bu, Jian-Liang Deng, Bin-Yuan Jiang, Liang-Dong Jiang, Xiao-Jie He
Summary: The study revealed that miR-485-3p suppresses osteosarcoma glycolysis, proliferation, and metastasis by inhibiting c-MET and AKT3/mTOR signaling, while MALAT1 acts as a sponge of miR-485-3p. These findings suggest that miR-485-3p and MALAT1 could be potential molecular targets for future osteosarcoma therapy.
Article
Pathology
Lisha Peng, Yong Wang, Jie Luo, Yan Liu, Feng Wang
Summary: This study aims to investigate the role of miR-128-3p in the radiosensitivity of nasopharyngeal carcinoma (NPC) and its underlying mechanism. It was found that miR-128-3p can affect cell proliferation, DNA damage, and cell apoptosis by regulating the expression of VEGFC, thereby enhancing the radiosensitivity of nasopharyngeal carcinoma cells. This finding provides a novel therapeutic target for overcoming radiation resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Madan L. Khurana, Indra Mani, Prerna Kumar, Chandramohan Ramasamy, Kailash N. Pandey
Summary: This study investigated the ANP-dependent downregulation of NPRA in different cell types, revealing the underlying mechanisms and biochemical changes involved in the process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)