Genomewide effects of peroxisome proliferator-activated receptor gamma in macrophages and dendritic cells - revealing complexity through systems biology

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

Agonistic induction of PPARγ reverses cigarette smoke–induced emphysema

(2014) Ming Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Unifying immunology with informatics and multiscale biology

(2014) Brian A Kidd et al.   NATURE IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Monocyte to Macrophage Differentiation Goes along with Modulation of the Plasmalogen Pattern through Transcriptional Regulation

(2014) Stefan Wallner et al.   PLoS One

The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology

(2013) Mate Kiss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Medical genetic inspirations for anticancer drug repurposing

(2013) Zhong-Yi Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture

(2012) K. Lee et al.   ATHEROSCLEROSIS

Genes2FANs: connecting genes through functional association networks

(2012) Ruth Dannenfelser et al.   BMC BIOINFORMATICS

Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach

(2012) Nathaniel D Lambert et al.   Expert Review of Vaccines

Identification of novel markers of alternative activation and potential endogenous PPARγ ligand production mechanisms in human IL-4 stimulated differentiating macrophages

(2012) Zsolt Czimmerer et al.   IMMUNOBIOLOGY

Cross-Species Transcriptional Network Analysis Defines Shared Inflammatory Responses in Murine and Human Lupus Nephritis

(2012) C. C. Berthier et al.   JOURNAL OF IMMUNOLOGY

PPARG Binding Landscapes in Macrophages Suggest a Genome-Wide Contribution of PU.1 to Divergent PPARG Binding in Human and Mouse

(2012) Sebastian Pott et al.   PLoS One

Recent progress using systems biology approaches to better understand molecular mechanisms of immunity

(2012) Rachel A. Gottschalk et al.   SEMINARS IN IMMUNOLOGY

Lists2Networks: Integrated analysis of gene/protein lists

(2010) Alexander Lachmann et al.   BMC BIOINFORMATICS

The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites

(2010) Tsuyoshi Waku et al.   EMBO JOURNAL

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

(2010) Serena Ghisletti et al.   IMMUNITY

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor   Function in Adipocytes and Macrophages

(2010) M. I. Lefterova et al.   MOLECULAR AND CELLULAR BIOLOGY

Research Resource: Transcriptome Profiling of Genes Regulated by RXR and Its Permissive and Nonpermissive Partners in Differentiating Monocyte-Derived Dendritic Cells

(2010) Lajos Széles et al.   MOLECULAR ENDOCRINOLOGY

Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease

(2010) R Hontecillas et al.   Mucosal Immunology

Visualization of omics data for systems biology

(2010) Nils Gehlenborg et al.   NATURE METHODS

Immunoregulatory Actions of Epithelial Cell PPAR γ at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease

(2010) Saroj K. Mohapatra et al.   PLoS One

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

(2010) Valerio Costa et al.   PPAR Research

Enabling a systems biology approach to immunology: focus on innate immunity

(2009) Jennifer L. Gardy et al.   TRENDS IN IMMUNOLOGY

Genome-wide profiling of PPAR :RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis

(2008) R. Nielsen et al.   GENES & DEVELOPMENT

The many faces of PPARγ: Anti-inflammatory by any means?

(2008) Attila Szanto et al.   IMMUNOBIOLOGY

Serum lipids regulate dendritic cell CD1 expression and function

(2008) David S. Leslie et al.   IMMUNOLOGY

Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/−bone marrow

(2008) Chaitra Marathe et al.   JOURNAL OF LIPID RESEARCH