Article
Chemistry, Applied
Feng-Ming Zhang, Yue-Hu Wang, Ping Zhao, Fu-Qiang Yu
Summary: A new p-terphenyl compound, 2',3'-diacetoxy-4,5,5',6',4'',5''-hexahydroxy-p-terphenyl (1), along with 12 known compounds, was isolated from the fruiting bodies of Sarcodon imbricatus (Bankeraceae). The new compound exhibited weak cytotoxicity against colon cancer SW480 and leukemia HL-60 cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hye Jin Yang, Eun-Bin Kwon, Jang-Gi Choi, Wei Li
Summary: Four new 26-carboxylated ergostane-type sterols were isolated from Sarcodon imbricatus. One of these sterols, sarcodonol D, showed significant antiviral activity and reduced virus-induced apoptosis by regulating mitochondrial stress. This study suggests that sarcodonol D is a potential candidate for antiviral treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Chunlan Shan, Fujun Miao
Summary: Hydroxytyrosol (HT), an important olive component, has immunomodulatory and antioxidant effects, enhancing immunity and antioxidant activities in the local mucosa of small intestines in broilers.
Article
Agriculture, Dairy & Animal Science
Kai Kang, Xinyi Deng, Weitian Xie, Jinjun Chen, Hongying Lin, Zhibao Chen
Summary: Rhodotorula mucilaginosa has immunoprotective effect on CTX-induced immunosuppression in mice by enhancing immune function and improving antioxidant capacity.
Article
Biochemistry & Molecular Biology
Jun -ping Liu, Jie Wang, Si-xuan Zhou, De-chun Huang, Guo-hong Qi, Gui-tang Chen
Summary: This study evaluated the immune-enhancing effect of ginger polysaccharides UGP1 and UGP2 on CTX-induced immunosuppressed mice. The results showed that ginger polysaccharides can alleviate the symptoms of weight loss and dietary intake reduction, increase fecal water content, protect immune organs, stimulate the secretion of cytokines and immunoglobulins, restore short-chain fatty acids levels in the intestine, and modulate gut microbiota associated with immune function. These findings suggest that ginger polysaccharides have the potential to be used as functional food ingredients or natural medicine for the treatment of intestinal barrier injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Zi-qi Dai, Li-jun Shang, Yu-shu Wei, Ze-qiang Li, Xiang-fang Zeng, Mei-xia Chen, Xin-yu Wang, Si-yu Li, Shiyan Qiao, Haitao Yu
Summary: Microcin C7 is a potential solution for pathogenic microbial infection and has gained substantial attention. This study evaluated its immunomodulatory activity in an immunodeficient mouse model and found that Microcin C7 treatment improved the state of the mice and enhanced immune function, intestinal health, and microbiota composition.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Marek Fol, Marcin Wlodarczyk, Magdalena Kowalewicz-Kulbat, Magdalena Druszczynska, Krzysztof T. Krawczyk, Sebastian Wawrocki, Wieslawa Rudnicka, Magdalena Chmiela
Summary: The study found that rBCG/IL-18 induced an increase in certain immune determinants, which remained present even in immunocompromised mice.
Article
Food Science & Technology
Hassan Barakat, Raghad I. Alkhurayji, Thamer Aljutaily
Summary: This study investigated the antioxidative and immune-boosting properties of the hydroalcoholic extract of Brassica nigra sprouts in rats with cyclophosphamide-induced immunosuppression. The results showed that the sprouts contained increasing levels of bioactive compounds and exhibited antioxidant activity during the sprouting period. In a rat model, dosing with the extract improved antioxidative stress and immune parameters in a dose-dependent manner. This suggests that mustard seed extracts have immunosuppressive properties against cyclophosphamide-induced immunosuppression.
Article
Veterinary Sciences
Gang Shu, Dan Xu, Jin Zhao, Lizi Yin, Juchun Lin, Hualin Fu, Huaqiao Tang, Jing Fang, Xi Peng, Xiaoling Zhao
Summary: Polygonatum sibiricum polysaccharide (PP) has protective effects on cyclophosphamide-induced immunosuppressed chickens, enhancing growth performance and immune system function.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Food Science & Technology
Ji-Da Wang, Li Wang, Shuang Yu, Yu-Tong Jin, Yi-Yang Wang, Run-Dong Chai, Ze-Yu Zhao, Yu-Hong Bian, Shu-Wu Zhao
Summary: The aim of this study was to investigate the effect of condensed Fuzheng extract (CFE) on immunosuppression. The results showed that CFE improved immune system organ function, stimulated immune cell activity, and increased the levels of immunoglobulins and cytokines. Therefore, CFE effectively alleviated immunosuppression and enhanced the immune functions of mice.
FOOD SCIENCE & NUTRITION
(2022)
Article
Chemistry, Medicinal
Andrea Manni, Yuan-Wan Sun, Todd D. Schell, Tymofiy Lutsiv, Henry Thompson, Kun-Ming Chen, Cesar Aliaga, Junjia Zhu, Karam El-Bayoumy
Summary: Using a mouse model of TNBC, researchers found that dietary administration of quercetin enhanced the antitumor effects of Cyclophosphamide, a cytotoxic drug used in TNBC treatment. Quercetin modified the host's fecal microbiome and increased the frequency of T cells and NK cells, while reducing the frequency of Treg. Overall, this study suggests that microbiota-centered dietary intervention can overcome resistance to chemoimmunotherapy in TNBC.
Article
Food Science & Technology
Ying-Jie Dong, Min-Qiu Lin, Xi Fang, Zhi-Yi Xie, Rong Luo, Xi Teng, Bin Li, Bo Li, Lin-Zi Li, Hai-Ying Jin, Qiao-Xian Yu, Gui-Yuan Lv, Su-Hong Chen
Summary: This study found that National Herbal Drink (NHD) can modulate the immune response in cyclophosphamide-induced immunocompromised mice by restoring intestinal barrier function and regulating gut microbiota disorders, thus improving immune regulation and enhancing immune functions.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Agriculture, Multidisciplinary
Dongpeng Wang, Yan Dong, Ying Xie, Yangxin Xiao, Chang Ke, Kun Shi, Zhongshi Zhou, Jiyuan Tu, Linghang Qu, Yanju Liu
Summary: This study evaluated the effects of Atractylodes lancea rhizome polysaccharide (ALP) on intestinal mucosal barrier and mucosal immunity in immunosuppressed mice. The results showed that ALP effectively enhanced immune organ index and blood cell count, stimulated cytokine secretion, and promoted the expression of key proteins involved in intestinal barrier function and T cells. ALP also improved gut microbiota imbalance and metabolic disorders, increasing the abundance of beneficial bacteria and short-chain fatty acids. This study provides a theoretical basis for the protective effects of ALP on intestinal health and immune function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Heggar Venkataramana Sudeep, Kuluvar Gouthamchandra, Illuri Ramanaiah, Amritha Raj, Puttaswamy Naveen, Kodimule Shyamprasad
Summary: This study investigated the immunomodulatory effects of Echinacea purpurea extract with enriched chicoric acid content. The extract showed antioxidant activity and increased nitric oxide production and cytokine release in cells. It also improved immune organ indices and serum cytokine levels in mice.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Food Science & Technology
Dongjing Zhang, Ming Xiang, Yun Jiang, Fen Wu, Huaqun Chen, Min Sun, Lingzhi Zhang, Xianfeng Du, Lei Chen
Summary: This study found that Sarcodon aspratus polysaccharides (SAFP) have potential health benefits for WIRS-induced gastric ulcer. SAFP can reduce inflammation, stress damage, and gastric mucosal lesion in rats, as well as regulate gut microbiota dysbiosis.
