期刊
SAUDI PHARMACEUTICAL JOURNAL
卷 25, 期 2, 页码 275-279出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2016.06.005
关键词
Gefitinib; Erlotinib; Resveratrol; Chalcones; Quinazolines; Cytotoxicity
A series of ten novel chalcone incorporated quinazoline derivatives(11a- 11j) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines(A549, HT-29, MCF-7 and A375). Among them, four compounds, 11f, 11g, 11i and 11j showed more potent anticancer activity than the control drug, Combretastatin - A4. (C) 2016 The Authors.
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