P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma

(2015) Dorota Skowronska-Krawczyk et al.   MOLECULAR CELL

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

(2015) Hyun-Jung Choi et al.   Nature Communications

A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin

(2015) Kapil Sirohi et al.   PLoS One

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

(2014) S Y Kim et al.   Cell Death & Disease

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma

(2012) Wael Osman et al.   HUMAN MOLECULAR GENETICS

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

(2012) Karim Nacerddine et al.   JOURNAL OF CLINICAL INVESTIGATION

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

(2012) Kang Zhang et al.   NATURE REVIEWS DRUG DISCOVERY

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

(2012) Anjum Riaz et al.   PLoS One

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

(2011) John H. Fingert et al.   HUMAN MOLECULAR GENETICS

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain

(2010) Ajay K Yadav et al.   Molecular Cancer

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bmi-1 Reduction Plays a Key Role in Physiological and Premature Aging of Primary Human Keratinocytes

(2009) Sonia Cordisco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Neural cell cycle dysregulation and central nervous system diseases

(2009) Wei Wang et al.   PROGRESS IN NEUROBIOLOGY

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE