Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

Neuroprotection by caffeine in the MPTP model of parkinson’s disease and its dependence on adenosine A 2A receptors

(2016) K. Xu et al.   NEUROSCIENCE

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma

(2016) Maria H. Madeira et al.   Scientific Reports

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro

(2015) João Martins et al.   ASN Neuro

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

(2015) Maria H. Madeira et al.   Journal of Neuroinflammation

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

(2015) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

(2014) Marcus Karlstetter et al.   Journal of Neuroinflammation

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

(2014) Ana R. Santiago et al.   MEDIATORS OF INFLAMMATION

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

Chronic caffeine treatment protects against experimental autoimmune encephalomyelitis in mice: Therapeutic window and receptor subtype mechanism

(2014) Tan Wang et al.   NEUROPHARMACOLOGY

Istradefylline: First Global Approval

(2013) Rosselle Dungo et al.   DRUGS

Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury

(2013) Steven F Abcouwer et al.   Journal of Neuroinflammation

What can we learn about stroke from retinal ischemia models?

(2012) Philippe M D'Onofrio et al.   ACTA PHARMACOLOGICA SINICA

Post-ischemic environmental enrichment protects the retina from ischemic damage in adult rats

(2012) Damián Dorfman et al.   EXPERIMENTAL NEUROLOGY

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation

(2012) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma

(2012) Beatriz I Gallego et al.   Journal of Neuroinflammation

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice

(2012) João M. N. Duarte et al.   PLoS One

A2A Adenosine Receptor (A2AAR) as a Therapeutic Target in Diabetic Retinopathy

(2011) Ahmed S. Ibrahim et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

(2010) Catarina V. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Complications of intravitreal injections

(2010) Kapil M Sampat et al.   CURRENT OPINION IN OPHTHALMOLOGY

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease

(2010) K. Xu et al.   NEUROSCIENCE

Caffeine attenuates lipopolysaccharide-induced neuroinflammation

(2010) Holly M. Brothers et al.   NEUROSCIENCE LETTERS

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

(2009) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Caffeine and an adenosine A2Areceptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

(2009) Giana P. Cognato et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells

(2009) Hélio Vitoriano Nobre et al.   NEUROCHEMISTRY INTERNATIONAL

Caffeine Enhances Astroglia and Microglia Reactivity Induced by 3,4-Methylenedioxymethamphetamine (‘Ecstasy’) in Mouse Brain

(2009) Amit Khairnar et al.   NEUROTOXICITY RESEARCH

Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels

(2008) S. Guerreiro et al.   MOLECULAR PHARMACOLOGY