Article
Virology
Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi, Yibin Peng, Fan Xin, Yi Lin, Qiong Wu, Xu Lin, Wannan Chen
Summary: The study reveals that the 2.2-kb HBV spliced variants encoded protein, HBDSP, promotes apoptosis in wt-p53 hepatocytes and induces the activation of p53-dependent apoptotic signaling pathway. Additionally, HBDSP increases the production of HBV progeny and viral antigens through the transactivation of the p53 promoter in an ETS1-, GATA2-, and YY1-dependent manner.
JOURNAL OF VIROLOGY
(2023)
Article
Medicine, General & Internal
Bangxiang Xie, Qian Hao, Xiang Zhou, Dexi Chen
Summary: The HBx protein of hepatitis B virus interacts with the TAp63 protein and inhibits its transcriptional activity, leading to the progression of hepatocellular carcinoma with defective p53.
CHINESE MEDICAL JOURNAL
(2022)
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Gurbet Celik-Turgut, Nazmiye Olmez, Tugba Koc, Ozden Ozgun-Acar, Asli Semiz, Yavuz Dodurga, Naciye Lale Satiroglu-Tufan, Alaattin Sen
Summary: The aim of this study was to investigate the interaction between aryl hydrocarbon receptor (AHR), nuclear factor -kappa B (NF-kB), and cytochrome P4501A1 (CYP1A1) with hepatitis B virus X protein (HBX). The results showed that NF-kB and AHR genes interacted with HBX, but there was no interaction between CYP1A1 and HBX proteins. This suggests that AHR and NF-kB play a role in HBV mechanism mediated via HBX, while CYP1A1 has no effect on this interaction.
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Wensheng Deng, Jiaoyu Ai, Wanlin Zhang, Zhenyu Zhou, Muqi Li, Likun Yan, Lidong Zhang, Zongjing Huang, Ziyi Wu, Junhua Ai, Hai Jiang
Summary: The HBx/PRMT9/HSPA8/CD44 axis was identified as a key signaling pathway regulating ferroptosis in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Long Liu, Yanping Huang, Yanan Fu, Jingjing Rao, Feng Zeng, Manshan Ji, Xiang Xu, Jianyong Zhu, Weixing Du, Zhixin Liu
Summary: This study elucidates the role of HBV-induced GP73 in regulating HCC development. HBV infection leads to upregulation of GP73 expression, which suppresses the host's innate immune response, thereby promoting HCC. These findings expand our understanding of the pathogenesis of HBV infection-induced HCC and provide preclinical support for GP73 as a potential therapeutic target for HCC.
INFECTIOUS AGENTS AND CANCER
(2022)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Yiming Lei, Xuan Xu, Huiling Liu, Lingjun Chen, Haoxiong Zhou, Jie Jiang, Yidong Yang, Bin Wu
Summary: The protein ARBB1 plays a critical role in HBV-related hepatocellular carcinoma by modulating autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis, suggesting it may be a potential therapeutic target for HCC.
Article
Gastroenterology & Hepatology
Shizhong Yang, Yanfeng Liu, Xiaobin Feng, Xiaojuan Wang, Meilong Wu, Lei Gong, Bin Shu, Qian Lu, Jiahong Dong
Summary: The study showed that HBx is highly expressed in HCC tissues and promotes migration and invasion of HCC cells, both in vitro and in vivo. HBx can serve as a novel therapeutic target for HCC.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ciniso Sylvester Shabangu, Phumelele Yvonne Siphepho, Chia-Yang Li, Wei-Chung Cheng, Ming-Ying Lu, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Zu-Yau Lin, Ming-Lung Yu, Shu-Chi Wang
Summary: Persistent HCV infection affects the interaction between the virus and host cell, leading to cell death or growth through different signaling pathways. It induces inflammatory responses and alters cell adhesion and chemokine signaling, promoting hepatocarcinogenesis.
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: Several dysregulated lncRNAs have been found to play important roles in HBV-related hepatocellular carcinoma, and may serve as biomarkers for early diagnosis and therapeutic targets.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)